{"id":325,"date":"2025-05-20T17:08:00","date_gmt":"2025-05-20T17:08:00","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/?page_id=325"},"modified":"2025-12-10T20:11:09","modified_gmt":"2025-12-10T20:11:09","slug":"2021-publication","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/2021-publication\/","title":{"rendered":"2021 Publications"},"content":{"rendered":"

Cao, C.;\u00a0 Kang, H. J.;\u00a0 Singh, I.;\u00a0 Chen, H.;\u00a0 Zhang, C.;\u00a0 Ye, W.;\u00a0 Hayes, B. W.;\u00a0 Liu, J.;\u00a0 Gumpper, R. H.;\u00a0 Bender, B. J.;\u00a0 Slocum, S. T.;\u00a0 Krumm, B. E.;\u00a0 Lansu, K.;\u00a0 McCorvy, J. D.;\u00a0 Kroeze, W. K.;\u00a0 English, J. G.;\u00a0 DiBerto, J. F.;\u00a0 Olsen, R. H. J.;\u00a0 Huang, X. P.;\u00a0 Zhang, S.;\u00a0 Liu, Y.;\u00a0 Kim, K.;\u00a0 Karpiak, J.;\u00a0 Jan, L. Y.;\u00a0 Abraham, S. N.;\u00a0 Jin, J<\/strong>.;\u00a0 Shoichet, B. K.;\u00a0 Fay, J. F.; Roth, B. L., Structure, function and pharmacology of human itch GPCRs. Nature<\/em><\/strong> 2021,<\/strong> 600<\/em>, 170-175. PMID:\u00a034789874<\/span><\/a>.<\/p>\n

Yu, X.; Li, D.; Kottur, J.<\/u>; Shen, Y.; Kim, H. S.; Park, K. S.; et al, Kaniskan, H. \u00dc<\/strong>.; Cai, L.; Jain, R.; Liu, J.; Aggarwal, A. K.; Wang, G. G.*; Jin, J.*<\/strong> A Selective WDR5 Degrader Inhibits Acute Myeloid Leukemia in Patient-Derived Mouse Models. Science Translational Medicine<\/em><\/strong>\u00a02021, 13, eabj1578. PMID:34586829<\/span><\/a>.<\/p>\n

Wei, J.; Meng, F.;<\/u>Park, K.; Yim, H.; Velez, J.; Kumar, P.; Wang, L.; Xie, L.; Chen, H.; Shen, Y.; Teichman, E.; Wang, G.; Chen, X.; Kaniskan, H.*; Jin, J<\/strong>.* Harnessing the E3 ligase KEAP1 for targeted protein degradation. J. Am. Chem. Soc.<\/em><\/strong> \u00a02021, 143, 37, 15073\u201315083. PMID: 34520194<\/a><\/span>\uff0cPMCID:PMC8480205.<\/p>\n

Xu, J.;\u00a0 Yu, X.; <\/u>\u00a0Martin, T. C.;\u00a0 Bansal, A.;\u00a0Cheung, K.;\u00a0 Lubin, A.;\u00a0 Stratikopoulos, E.;\u00a0 Cahuzac, K. M.;\u00a0 Wang, L.;\u00a0Xie, L.;\u00a0 Zhou, R.;\u00a0 Shen, Y.;\u00a0Wu, X.;\u00a0 Yao, S.;\u00a0 Qiao, R.;\u00a0Poulikakos, P. I.;\u00a0 Chen, X.;\u00a0 Liu, J.;\u00a0Jin, J.<\/strong>*; Parsons, R.* AKT degradation selectively inhibits the growth of PI3K\/PTEN pathway mutant cancers with wild-type KRAS and BRAF by destabilizing Aurora kinase B. Cancer Discovery <\/strong>2021, 11, 3064-3089. <\/em>PMID:\u00a034301793<\/a><\/span>.<\/p>\n

Lu, S. X.;\u00a0De Neef, E.;\u00a0 Thomas, J. D.; \u00a0Sabio, E.;\u00a0 Rousseau, B.;\u00a0Gigoux, M.;\u00a0 Knorr, D. A.;\u00a0 Greenbaum, B.;\u00a0 Elhanati, Y.;\u00a0Hogg, S. J.;\u00a0 Chow, A.;\u00a0 Ghosh, A.;\u00a0Xie, A.;\u00a0 Zamarin, D.;\u00a0 Cui, D.;\u00a0Erickson, C.;\u00a0 Singer, M.;\u00a0 Cho, H.;\u00a0Wang, E.;\u00a0 Lu, B.;\u00a0 Durham, B. H.;\u00a0 Shah, H.;\u00a0Chowell, D.;\u00a0 Gabel, A. M.;\u00a0 Shen, Y.;\u00a0Liu, J.;\u00a0 Jin, J.<\/strong>;\u00a0 Rhodes, M. C.;\u00a0 Taylor, R. E.;\u00a0 Molina, H.;\u00a0Wolchok, J. D.;\u00a0 Merghoub, T.;\u00a0 Diaz, L. A.;\u00a0Abdel-Wahab, O.*; Bradley, R. K.* Pharmacologic modulation of RNA splicing enhances anti-tumor immunity. Cell, <\/strong><\/em>2021, 184,\u00a0<\/em>4032-4047.\u00a0PMID: <\/span>34171309<\/a><\/span><\/span><\/p>\n

Dale, B.; Cheng, M.;\u00a0<\/u>Park, K.-S.; Kaniskan, H. \u00dc<\/strong>.; Xiong, Y.*; Jin, J<\/strong>*. Advancing targeted protein degradation for cancer therapy. Nature Reviews Cancer<\/em><\/strong>2021, 21, 638-654. PMID:\u00a034131295<\/a><\/span>, PMCID:\u00a0PMC8463487.<\/p>\n

Li, J.; Galbo, P. M., Jr.; Gong, W.; Storey, A. J.; Tsai, Y. H.; Yu, X.; Ahn, J. H.;Guo, Y.; Mackintosh, S. G.; Edmondson, R. D.; Byrum, S. D.; Farrar, J. E.; He, S.; Cai, L.; Jin, J.<\/strong>; Tackett, A. J.; Zheng, D.; Wang, G. G.* ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4\/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism. Nat. Commun<\/strong>.\u00a0<\/em>2021,\u00a012<\/em>, 1045. PMID:\u00a033594072<\/span><\/a>, PMCID: PMC7886901.<\/p>\n

Wu, X.; Yang, X.; Xiong, Y.; Li, R.; Ito, T.; Ahmed, T. A.; Karoulia, Z.; Adamopoulos, C.; Wang, H.; Wang, L.; Xie, L.; Liu, J.; Ueberheide, B.; Aaronson, S. A.; Chen, X.; Buchanan, S. G.; Sellers, W.R.;\u00a0Jin, J.;<\/strong> Poulikakos, P. I.* Distinct CDK6 complexes determine tumor cell response to CDK4\/6 inhibitors and degraders. Nature Cancer <\/i><\/strong>2021, 2, <\/em>429-443.<\/p>\n

Bhat, K. P.<\/u>;\u00a0 \u00dcmit Kaniskan, H.<\/u><\/strong>;\u00a0 Jin, J.*<\/strong>; Gozani, O.* Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease. Nat. Rev. Drug Discov.\u00a0<\/i>2021, <\/strong>20, 265-286. PMID: 33469207<\/a><\/span>, PMCID: PMC8035146.<\/strong><\/p>\n

Xu, J.;\u00a0 Yu, X.;\u00a0 Martin, T. C.;\u00a0 Bansal, A.; Cheung, K.;\u00a0 Lubin, A.;\u00a0 Stratikopoulos, E.;\u00a0 Cahuzac, K. M.;\u00a0 Wang, L.; Xie, L.;\u00a0 Zhou, R.;\u00a0 Shen, Y.; Wu, X.;\u00a0 Yao, S.;\u00a0 Qiao, R.; Poulikakos, P. I.;\u00a0 Chen, X.; Liu, J., Jin, J.*; Parsons, R.* AKT Degradation Selectively Inhibits the Growth of PI3K\/PTEN Pathway Mutant Cancers with Wild Type KRAS and BRAF by Destabilizing Aurora Kinase B, Cancer Discovery <\/strong>, 2021, 11, 3064-3089.
\nPMID: 34301793 <\/a> <\/span>PMCID: PMC9056008.<\/p>\n

Posted on Dec 10, 2025<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Cao, C.;\u00a0 Kang, H. J.;\u00a0 Singh, I.;\u00a0 Chen, H.;\u00a0 Zhang, C.;\u00a0 Ye, W.;\u00a0 Hayes, B. W.;\u00a0 Liu, J.;\u00a0 Gumpper, R. H.;\u00a0 Bender, B. J.;\u00a0 Slocum, S. T.;\u00a0 Krumm, B. E.;\u00a0 Lansu, K.;\u00a0 McCorvy, J. D.;\u00a0 Kroeze, W. K.;\u00a0 English, J. G.;\u00a0 DiBerto, J. F.;\u00a0 Olsen, R. H. J.;\u00a0 Huang, X. P.;\u00a0 Zhang, S.;\u00a0 Liu, Y.;\u00a0 […]<\/p>\n","protected":false},"author":43,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-325","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/pages\/325","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/users\/43"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/comments?post=325"}],"version-history":[{"count":7,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/pages\/325\/revisions"}],"predecessor-version":[{"id":400,"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/pages\/325\/revisions\/400"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/center-for-therapeutics-discovery\/wp-json\/wp\/v2\/media?parent=325"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}