Publications

Selected Publications

2021

Lei Guo, Margaret B Zhong, Larry Zhang, Bin Zhang and Dongming Cai (2021) Sex differences in Alzheimer’s disease: Insights from multi-Omics landscape. Biol Psych (in press); NIHMS1679133

Ryan Neff, Minghui Wang, Sezen Vatansever, Lei Guo, Chen Ming, Qian Wang, Erming Wang, Emrin Horgusluoglu-Moloch, Won-min Song, Aiqun Li, Emilie Castranio, Julia TCW, Lap Ho, Alison Goate, Valentina Fossati, Scott Noggle, Sam Gandy, Michelle E. Ehrlich, Pavel Katsel, Eric Schadt, Dongming Cai, Kristen J. Brennand, Vahram Haroutunian, Bin Zhang (2021) Molecular subtyping of Alzheimer’s Disease Using RNA-sequencing data reveals novel mechanisms and target. Science Advances Jan 6th 7(2): abb 5398. https://doi.org/10.1126/sciadv.abb5398

Minghui Wang, Aiqun Li, Michiko Sekiya, Noam D. Beckmann, Xiuming Quan, Nadine Schrode, Michael B. Fernando, Alex Yu, Li Zhu, Jiqing Cao, Liwei Lyu, Emrin Horgusluoglu, Qian Wang, Lei Guo, Yuan-shuo Wang, Ryan Neff, Won-min Song, Erming Wang, Qi Shen, Xianxiao Zhou, Chen Ming, Seok-Man Ho, Sezen Vatansever, H. Umit Kaniskan, Jian Jin, Ming-Ming Zhou, Kanae Ando, Lap Ho, Paul A. Slesinger, Zhenyu Yue, Jun Zhu, Sam Gandy, Michelle E. Ehrlich, Dongming Cai, Vahram Haroutunian, Koichi M. Iijima, Eric Schadt, Kristen J. Brennand and Bin Zhang (2021) Transformative network modeling of multi-omics data reveals detailed circuits, key regulators and potential therapeutics for Alzheimer’s disease. Neuron 109 (2): 257-272 e14.

Carlos A. Toro, Jens Hansen, Mustafa M. Siddiq, Kaitlin Johnson, Wei Zhao, Daniella Azulai, Dibash K. Das, William A. Bauman, Robert Sebra, Dongming Cai, Ravi Iyengar, Christopher P. Cardozo (2021) The human ApoE4 variant reduces functional recovery and neuronal sprouting after incomplete spinal cord injury in male mice. Cell. Neurosci., 18 February 2021 https://doi.org/10.3389/fncel.2021.626192 

2020

Jiqing Cao, Min Huang, Lei Guo, Li Zhu, Jianwei Hou, Larry Zhang, Adriana Pero, Sabrina Ng, Farida El Gaamouch, Gregory Elder, Mary Sano, Alison Goate, Julia TCW, Vahram Haroutunian, Bin Zhang and Dongming Cai (2020) MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer’s Disease pathogenesis. Mol Psych July 6. PMCID: PMC7785685

2019

Carlos A. Toro, Dongming Cai and Christopher Cardozo (2019) Elucidating the role of ApoE isoforms in spinal cord injury-associated neuropathology. J Neurotrauma 36:1-6.

Carlos A. Toro, Larry Zhang, Jianwei Hou, and Dongming Cai (2019) Sex differences in Alzheimer’s disease: understanding the molecular impact. Brain Res. VSI: Sex and the brain 1719: 194-207.

Jiqing Cao, Margaret B Zhong, Carlos A. Toro, Larry Zhang, and Dongming Cai (2019) Endo-lysosomal pathway and ubiquitin-proteasome system dysfunction in Alzheimer’s Disease pathogenesis. Letters VSI: Alzheimer’s Disease – Advances in Molecular Pathogenesis 703:68-78.

2018

Jiqing Cao, Jianwei Hou, Ping Jing and Dongming Cai (2018) Advances in developing novel therapeutic strategies for Alzheimer’s disease. Mol Neurodegener 13(1):64. PMCID: PMC6291983

2017

Jiqing Cao, Farida El Gaamouch, James S. Meabon, Kole Meeker, Li Zhu, Margaret B. Zhong, John Bendik, Gregory Elder, Ping Jing, Jiahong Xia, David G Cook, and Dongming Cai (2017) ApoE4-associated phospholipid dysregulation contributes to development of AD after mild TBI exposure. Scientific Reports 7(1):11372. PMCID: PMC5595858

2015

Zhu L, Zhong M, Elder GA, Sano M, Holtzman DM, Gandy S, Cardozo C, Haroutunian V, Robakis NK, Cai D (2015) Phospholipid dysregulation contributes to ApoE4-associated cognitive deficits in Alzheimer’s disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America 112(38):11965-70

2013

Zhu L, Zhong M, Zhao J, Rhee H, Caesar I, Knight EM, Volpicelli-Daley L, Bustos V, Netzer W, Liu L, Lucast L, Ehrlich ME, Robakis NK, Gandy SE, Cai D (2013) Reduction of synaptojanin 1 accelerates Aβ clearance and attenuates cognitive deterioration in an Alzheimer mouse model.The Journal of Biological Chemistry 288(44):32050-63.