{"id":20,"date":"2016-03-22T17:57:12","date_gmt":"2016-03-22T17:57:12","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/buettnerlab\/?page_id=20"},"modified":"2016-03-22T18:34:13","modified_gmt":"2016-03-22T18:34:13","slug":"research-and-grants","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/buettnerlab\/research-and-grants\/","title":{"rendered":"Research and Grants"},"content":{"rendered":"<p>ACTIVE<br \/>\n1.\u00a0\u00a0\u00a0\u00a0\u00a0 PI \u2013 3.0 calendar months effort,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Total direct cost budget: $1,125,000<br \/>\n\u201cA Role of Hypothalamic Dysfunction in Alcoholic Liver Disease\u201d<br \/>\nThe major goal is to study a role of hypothalamic dysfunction in alcoholic liver disease<br \/>\nNIH\/NIDDK -1 R01 AA023416-01.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 02\/01\/2014 &#8211; 01\/31\/2019<\/p>\n<p>2.\u00a0\u00a0\u00a0\u00a0\u00a0 PI \u2013 2.4 calendar months effort,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Total direct cost budget: $ 800,000<br \/>\n\u201cBrain insulin as a regulator of Sepsis survival\u201d<br \/>\nThe major goal is to define a role of brain insulin as a regulator of innate immunity<br \/>\nCareer Development Award 7-11-CD-02\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 01\/01\/2012-12\/31\/2017<\/p>\n<p>3.\u00a0\u00a0\u00a0\u00a0\u00a0 Co-PI \u2013 0.06 calendar months effort,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Total direct cost budget: $ 6,000,000<br \/>\n\u201cIntegrative Biology Approach to Complexity of Alzheimer\u2019s Disease\u201d<br \/>\nGoal is to identify gene networks that are shared between Alzheimers and Diabetes.<br \/>\nMount Sinai School of Medicine 1 UO1 AG046170 01 (Schadt Eric E) 09-20-2013-09-19-2018<\/p>\n<p>4.\u00a0\u00a0\u00a0\u00a0\u00a0 Co-PI\/Project 2, leader \u2013 2.4calendar months effort Total direct cost budget: $ 1,843,698<br \/>\n\u201cAlzheimers disease and Diabetes\u201d<br \/>\nThe goal is to study insulin signaling in several cell types derived from inducible pluripotent stem cells from patients with Alzheimer\u2019s.<br \/>\nNIA, P50 AG 005138 (PI Sano PI)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 01\/01\/2015-12\/31\/2019<\/p>\n<p>5.\u00a0\u00a0\u00a0\u00a0\u00a0 PI \u2013 administrative supplement\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Total direct cost budget: $ 149,903<br \/>\n\u201cA Role of Hypothalamic Dysfunction in Alcoholic Liver Disease\u201d<br \/>\nThis is a minority supplement.<br \/>\nNIH\/NIDDK -1 R01 AA023416-01S1.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 07\/01\/2014 &#8211; 12\/31\/2016<\/p>\n<p>6.\u00a0\u00a0\u00a0\u00a0\u00a0 Mentor\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Total direct cost budget: $750,000<br \/>\n\u201cPerinatal Exposure to Environmental DDT and Risk of Metabolic Syndrome\u201d<br \/>\nHere we examine if and through what mechanisms perinatal exposure to DDT increases the metabolic syndrome.<br \/>\nNIH NIEHS &#8211; K99\/ROO ES019919 (La Merrill)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 08\/01\/2011-7\/31\/2016<\/p>\n<p>7.\u00a0\u00a0\u00a0\u00a0\u00a0 Mentor\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Total direct cost budget: $578,016<br \/>\n\u201cRole of Brain Insulin in the regulation of Branched Chain Amino acid Metabolism\u201d<br \/>\nThe goal is to define a role of brain insulin signaling in regulating BCAA catabolism.<br \/>\nNIDKK &#8211; 1 K01 DK099463 01 (Shin Andrew)\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 09-20-2013-09-19-2017<\/p>\n<p>PREVIOUS GRANT SUPPORT<br \/>\n1.\u00a0\u00a0\u00a0\u00a0\u00a0 PI \u2013 0.6 calendar\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Total direct cost budget: $35,000<br \/>\n\u201cBrain insulin as a regulator of innate immunity.\u201d<br \/>\nHirschl\/Monique Weill-Caulier Trust\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 01\/01\/2010-12\/31\/2015<br \/>\n2.\u00a0\u00a0\u00a0\u00a0\u00a0 PI &#8211; 3.36 calendar\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Total direct cost budget: $240,000<br \/>\n\u201cThe regulation of adipose tissue by central insulin and leptin. \u201d<br \/>\nNIH\/NIDKK &#8211; R01-0836581\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 07\/01\/2009-06\/30\/2014<br \/>\n3.\u00a0\u00a0\u00a0\u00a0\u00a0 PI &#8211; 1.32 calendar\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Total direct cost budget: $ 120,000<\/p>\n","protected":false},"excerpt":{"rendered":"<p>ACTIVE 1.\u00a0\u00a0\u00a0\u00a0\u00a0 PI \u2013 3.0 calendar months effort,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Total direct cost budget: $1,125,000 \u201cA Role of Hypothalamic Dysfunction in Alcoholic Liver Disease\u201d The major goal is to study a role of hypothalamic dysfunction in alcoholic liver disease NIH\/NIDDK -1 R01 AA023416-01.\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 02\/01\/2014 &#8211; 01\/31\/2019 2.\u00a0\u00a0\u00a0\u00a0\u00a0 PI \u2013 2.4 calendar months effort,\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Total direct cost budget: [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-20","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/buettnerlab\/wp-json\/wp\/v2\/pages\/20","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/buettnerlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/buettnerlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/buettnerlab\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/buettnerlab\/wp-json\/wp\/v2\/comments?post=20"}],"version-history":[{"count":2,"href":"https:\/\/labs.icahn.mssm.edu\/buettnerlab\/wp-json\/wp\/v2\/pages\/20\/revisions"}],"predecessor-version":[{"id":52,"href":"https:\/\/labs.icahn.mssm.edu\/buettnerlab\/wp-json\/wp\/v2\/pages\/20\/revisions\/52"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/buettnerlab\/wp-json\/wp\/v2\/media?parent=20"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}