{"id":580,"date":"2020-05-04T19:37:51","date_gmt":"2020-05-04T19:37:51","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/bogunoviclab\/?page_id=580"},"modified":"2020-05-08T18:49:53","modified_gmt":"2020-05-08T18:49:53","slug":"covid-19","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/bogunoviclab\/covid-19\/","title":{"rendered":"COVID-19"},"content":{"rendered":"<p><strong>COVID-19<\/strong> is a disease caused by a coronavirus, Severe Acute Respiratory Syndrome (SARS) -CoV-2. Infections by SARS-CoV-2 are now present in every country around the globe, causing unprecedented public health burden. SARS-CoV is known to interfere with IFN-I induction and signaling.<\/p>\n<p><a href=\"https:\/\/labs.icahn.mssm.edu\/bogunoviclab\/wp-content\/uploads\/sites\/19\/2020\/05\/Coronavirus-CDC-645x645.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-583 aligncenter\" src=\"https:\/\/labs.icahn.mssm.edu\/bogunoviclab\/wp-content\/uploads\/sites\/19\/2020\/05\/Coronavirus-CDC-645x645-300x300.jpg\" alt=\"\" width=\"300\" height=\"300\" srcset=\"https:\/\/labs.icahn.mssm.edu\/bogunoviclab\/wp-content\/uploads\/sites\/19\/2020\/05\/Coronavirus-CDC-645x645-300x300.jpg 300w, https:\/\/labs.icahn.mssm.edu\/bogunoviclab\/wp-content\/uploads\/sites\/19\/2020\/05\/Coronavirus-CDC-645x645-150x150.jpg 150w, https:\/\/labs.icahn.mssm.edu\/bogunoviclab\/wp-content\/uploads\/sites\/19\/2020\/05\/Coronavirus-CDC-645x645.jpg 645w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>COVID-19<\/strong> <strong>and Broad Spectrum Antiviral<\/strong><\/li>\n<\/ul>\n<p>ISG15 and USP18 are considered to be <em>bona fide<\/em> negative regulators of IFN-I. Our <em>ex vivo<\/em> data suggest that both, ISG15 -\/- and USP18<em> -\/-<\/em> patients have increased levels of IFN-I-induced gene expression. Our <em>in vitro<\/em> data suggest that cells from these individuals control viral infections more effectively than cells from WT individuals. We are currently trying to demonstrate enhanced resistance to Sars-CoV-2.<\/p>\n<p>Based on these human genetic <em>in vivo<\/em>, <em>ex vivo<\/em>, <em>in vitro<\/em> and biochemical findings, we hypothesize that ISG15\/USP18 inhibition by a small molecule would temporarily increase antiviral immunity in WT individuals. In parallel, we are developing deliverable therapeutics which would mimic ISG15-like transcriptional profile and thus augment antiviral immunity in WT individuals.<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>COVID-19 in Down Syndrome Individuals<\/strong><\/li>\n<\/ul>\n<p class=\"\">Down syndrome (DS) is the most common genetic cause of intellectual and developmental disabilities in children and young adults with Incidence in US of about 1 in 600 individuals. Individuals with DS often have cardiac and gastrointestinal abnormalities. Additionally, they have a number of immune-related problems from increased susceptibility to an array of infectious diseases to autoimmunity. Unfortunately, the exact molecular mechanism leading to these immune defects has not been elucidated.<\/p>\n<p class=\"\">DS is, in most cases, caused by an extra chromosome 21, on which the receptors for type I Interferons (IFNAR1 and IFNAR2) are encoded.\u00a0 How this gene dosage effects are contributing to SARS-CoV-2 pathophysiology is not understood. To which extent SARS-CoV-2 can cause illness in individuals with DS is currently unknown.We are currently addressing a number of scientific questions pertaining to this pathophysiology.<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li><strong>COVID-19<\/strong> &#8211; <strong>Genetic Susceptibility<\/strong><\/li>\n<\/ul>\n<p>Many otherwise healthy individuals below 30 years of age, infected with Sars-CoV-2 remain asymptomatic but select few succumb to disease. How host genetics influences these discrepant COVID-19 outcomes is unknown. By improving our understanding of the human determinants of Sars-CoV-2, we should be able to develop new hypotheses concerning both human susceptibility in vivo and drug development.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>COVID-19 is a disease caused by a coronavirus, Severe Acute Respiratory Syndrome (SARS) -CoV-2. Infections by SARS-CoV-2 are now present in every country around the globe, causing unprecedented public health burden. SARS-CoV is known to interfere with IFN-I induction and signaling. &nbsp; COVID-19 and Broad Spectrum Antiviral ISG15 and USP18 are considered to be bona [&hellip;]<\/p>\n","protected":false},"author":21,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-580","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/bogunoviclab\/wp-json\/wp\/v2\/pages\/580","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/bogunoviclab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/bogunoviclab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/bogunoviclab\/wp-json\/wp\/v2\/users\/21"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/bogunoviclab\/wp-json\/wp\/v2\/comments?post=580"}],"version-history":[{"count":15,"href":"https:\/\/labs.icahn.mssm.edu\/bogunoviclab\/wp-json\/wp\/v2\/pages\/580\/revisions"}],"predecessor-version":[{"id":703,"href":"https:\/\/labs.icahn.mssm.edu\/bogunoviclab\/wp-json\/wp\/v2\/pages\/580\/revisions\/703"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/bogunoviclab\/wp-json\/wp\/v2\/media?parent=580"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}