{"id":957,"date":"2024-10-29T13:25:24","date_gmt":"2024-10-29T17:25:24","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/?page_id=957"},"modified":"2024-10-29T13:25:37","modified_gmt":"2024-10-29T17:25:37","slug":"harnessing-the-dark-genome-in-mrna-cancer-vaccination","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/researchareas\/harnessing-the-dark-genome-in-mrna-cancer-vaccination\/","title":{"rendered":"Harnessing the dark genome in mRNA cancer vaccination"},"content":{"rendered":"<p><span class=\"markee91c7oyv\" data-markjs=\"true\" data-ogac=\"\" data-ogab=\"\" data-ogsc=\"\" data-ogsb=\"\" data-olk-copy-source=\"MessageBody\">Ashley<\/span>\u00a0investigates how repetitive transposable elements (TEs) can be therapeutically harnessed to boost cancer vaccination as part of the Bhardwaj and Vabret Labs. TEs have recently gained recognition as part of a &#8216;viral mimicry&#8217; response to epigenetic therapy in cancer &#8211; a phenomenon where innate immune sensing of TEs leads to a type I interferon response. Additionally, recent publications have shown that TEs can form tumor antigens that activate T cells in patients.\u00a0<span class=\"markee91c7oyv\" data-markjs=\"true\" data-ogac=\"\" data-ogab=\"\" data-ogsc=\"\" data-ogsb=\"\">Ashley<\/span>\u00a0has developed a novel screening platform to identify drugs that activate a TE-mediated viral mimicry response and is using the drugs identified through this screening to boost mRNA cancer vaccine efficacy of both traditional (tumor associated antigens and neoantigens) and TE antigen-targeting\u00a0cancer vaccines.\u00a0<span class=\"markee91c7oyv\" data-markjs=\"true\" data-ogac=\"\" data-ogab=\"\" data-ogsc=\"\" data-ogsb=\"\">Ashley<\/span>&#8216;s work currently focuses on mouse models of melanoma but the ultimate goal is to combine the TE viral mimicry response with cancer vaccination across different tumor types as a novel immunotherapy approach<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ashley\u00a0investigates how repetitive transposable elements (TEs) can be therapeutically harnessed to boost cancer vaccination as part of the Bhardwaj and Vabret Labs. TEs have recently gained recognition as part of a &#8216;viral mimicry&#8217; response to epigenetic therapy in cancer &#8211; a phenomenon where innate immune sensing of TEs leads to a type I interferon response. [&hellip;]<\/p>\n","protected":false},"author":184,"featured_media":0,"parent":52,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-957","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/pages\/957","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/users\/184"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/comments?post=957"}],"version-history":[{"count":1,"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/pages\/957\/revisions"}],"predecessor-version":[{"id":979,"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/pages\/957\/revisions\/979"}],"up":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/pages\/52"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/media?parent=957"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}