{"id":774,"date":"2022-03-09T13:06:30","date_gmt":"2022-03-09T18:06:30","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/?page_id=774"},"modified":"2022-03-10T12:25:55","modified_gmt":"2022-03-10T17:25:55","slug":"t-cell-dysfunction-in-hpv-related-malignancies","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/t-cell-dysfunction-in-hpv-related-malignancies\/","title":{"rendered":"NK and T cell dysfunction in HPV-related malignancies"},"content":{"rendered":"<p><span style=\"text-decoration: underline\"><strong>KAZUKI SONE MD PHD<\/strong><\/span><\/p>\n<p>Kazuki is investigating effector cell dysfunction in HPV-associated cancer. HPV- associated cancers are recognized as an ideal target for T cell and NK cell based immunotherapy, such as vaccines or immune checkpoint inhibition. Several immune checkpoint inhibitors such as anti-PD-1 and anti-NKG2A antibodies, and therapeutic vaccine using viral antigens are reported to have anti-tumor activity in human and mice models. However, the clinical efficacy of these approaches is still not optima, with 30-35% anti-tumor response even when combining both approaches. Kazuki utilizes T cell assay and various single-cell\u00a0techniques to characterize the phenotype, function of T cell and NK cell dysregulation in head and neck cancer with HPV. He also uses patient-derived organoid co-culture system with immune cells to identify the mechanism of immune-resistance. His goal is to improve our understanding of the immune response against HPV-associated cancers to facilitate better, precision immunotherapy for these malignancies.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>KAZUKI SONE MD PHD Kazuki is investigating effector cell dysfunction in HPV-associated cancer. HPV- associated cancers are recognized as an ideal target for T cell and NK cell based immunotherapy, such as vaccines or immune checkpoint inhibition. Several immune checkpoint inhibitors such as anti-PD-1 and anti-NKG2A antibodies, and therapeutic vaccine using viral antigens are reported [&hellip;]<\/p>\n","protected":false},"author":184,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-774","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/pages\/774","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/users\/184"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/comments?post=774"}],"version-history":[{"count":3,"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/pages\/774\/revisions"}],"predecessor-version":[{"id":795,"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/pages\/774\/revisions\/795"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/media?parent=774"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}