{"id":1030,"date":"2026-02-02T17:14:46","date_gmt":"2026-02-02T22:14:46","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/?page_id=1030"},"modified":"2026-02-03T18:13:14","modified_gmt":"2026-02-03T23:13:14","slug":"engineering-cytokine-mrna-lnps-to-induce-cdc1-dependent-anti-tumor-immunity","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/researchareas\/engineering-cytokine-mrna-lnps-to-induce-cdc1-dependent-anti-tumor-immunity\/","title":{"rendered":"Engineering Cytokine mRNA-LNPs to Induce cDC1-Dependent Anti-Tumor Immunity"},"content":{"rendered":"<p><span data-olk-copy-source=\"MessageBody\">Xinying&#8217;s research focuses on engineering mRNA-LNPs to deliver a triad of immunomodulators that locally drive the recruitment, expansion, and immunogenic activation of conventional type I dendritic cells (cDC1s). This strategy aims to reconstitute a cDC1-dependent positive feedback loop between NK cells and T cells within the tumor microenvironment to overcome immune exclusion. By restoring these essential interactions, we seek to drive robust, antigen-dependent anti-tumor immunity<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Xinying&#8217;s research focuses on engineering mRNA-LNPs to deliver a triad of immunomodulators that locally drive the recruitment, expansion, and immunogenic activation of conventional type I dendritic cells (cDC1s). This strategy aims to reconstitute a cDC1-dependent positive feedback loop between NK cells and T cells within the tumor microenvironment to overcome immune exclusion. By restoring these [&hellip;]<\/p>\n","protected":false},"author":184,"featured_media":0,"parent":52,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1030","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/pages\/1030","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/users\/184"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/comments?post=1030"}],"version-history":[{"count":3,"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/pages\/1030\/revisions"}],"predecessor-version":[{"id":1048,"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/pages\/1030\/revisions\/1048"}],"up":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/pages\/52"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/bhardwajlab\/wp-json\/wp\/v2\/media?parent=1030"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}