[\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#000000″ text_font_size=”18px” text_line_height=”1.8em” global_colors_info=”{}”]<\/p>\n
The Bevacqua Lab<\/strong> studies human diabetes, with the goal of expanding and improving human pancreatic beta cell mass function for the 400+ million people in the world with diabetes. More specifically, we focus on pancreatic islet biology, attempting to understand the regulatory mechanisms driving postnatal human islet maturation and the genetic basis for their dysregulation in disease, findings that will be applied towards \u03b2-cell regeneration and replacement therapies. Questions of the Bevacqua lab include: \u201cWhat transcription factors are required for proper maturation of human islet cells?<\/em>\u201d \u201cWhat is the role of non-coding regulatory elements in modulating mature function of islets?<\/em>\u201d \u201cWhat mechanisms are perturbed by risk variants linked to diabetes?<\/em>\u201d And, \u201cWhat are the roles of chromatin modification and external signals in regulating this terminal maturation?<\/em>\u201d<\/p>\n Our recent development of genetic systems in primary human islet organoids, termed \u201cpseudoislets\u201d, now provides unprecedented methods to investigate mechanisms regulating function of mature islets. Our approaches will include implementation of novel genomic approaches in vivo<\/em> to reverse diabetes, and will open new possibilities for the treatment of patients with diabetes.<\/p>\n [\/et_pb_text][et_pb_text admin_label=”General Overview of Research” _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#0C71C3″ text_font_size=”22px” global_colors_info=”{}”]<\/p>\n General Overview of Research<\/strong><\/p>\n [\/et_pb_text][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bevacqualab\/wp-content\/uploads\/sites\/467\/2023\/02\/1-General-Overview_new-1.jpg” title_text=”1-General-Overview_new” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Research Methods Section” module_id=”methods” module_class=”methods-section” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Research Methods Title” _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#0C71C3″ text_font_size=”22px” global_colors_info=”{}”]<\/p>\n Research Methods: Innovative Systems to Study Human Islet Biology<\/b><\/strong><\/p>\n [\/et_pb_text][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bevacqualab\/wp-content\/uploads\/sites\/467\/2023\/02\/3_Methods_NEW.jpg” title_text=”3_Methods_NEW” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Projects Section” module_id=”projects” module_class=”projects-section” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=” title Text” _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#0C71C3″ text_font_size=”22px” global_colors_info=”{}”]<\/p>\n Projects<\/strong><\/p>\n [\/et_pb_text][et_pb_accordion _builder_version=”4.16″ _module_preset=”default” toggle_font_size=”18px” global_colors_info=”{}”][et_pb_accordion_item title=”Project 1. Identification of transcription factors and pathways driving pancreatic islet maturation.” open=”on” open_toggle_text_color=”#000000″ open_toggle_background_color=”#FFFFFF” closed_toggle_background_color=”#FFFFFF” icon_color=”#006ac1″ use_icon_font_size=”on” _builder_version=”4.16″ _module_preset=”default” body_font=”Open Sans||||||||” body_text_color=”#000000″ border_width_all=”0.5px” border_color_all=”#006ac1″ global_colors_info=”{}” toggle_text_color=”#000000″ toggle_font=”Open Sans|700|||||||” toggle_font_size=”18px”]<\/p>\n Transcription factors (TFs) play a critical role in regulating \u03b2-cell maturation, as evidenced by studies of human monogenic diabetes mellitus, and impaired \u03b2-cell function resulting from mutations in multiple TF genes. In recent years, many human-specific TFs differentially expressed across development and disease states were identified, reflecting efforts to reliably procure human islets for research, and advances in NGS-based technologies for small cell number samples. Using genetic systems in primary human pseudoislets, the Bevacqua lab studies mechanisms regulated by TFs dynamically expressed in human islet b- and a-cells. We hypothesize that TFs showing dynamic expression during a critical window of developmental maturation, and linked to diabetes disease risk, could drive the maturation of these cells. Our studies should elucidate new genetic and chromatin regulatory networks that govern human islet cell function, and provide a much-sought \u2018roadmap\u2019 for guiding current world-wide islet cell replacement and regeneration efforts.<\/p>\n [\/et_pb_accordion_item][et_pb_accordion_item title=”Project 2. Deciphering non-coding regulatory mechanisms driving islet cell maturation and dysregulation.” open_toggle_text_color=”#000000″ open_toggle_background_color=”#FFFFFF” closed_toggle_background_color=”#FFFFFF” icon_color=”#006ac1″ use_icon_font_size=”on” _builder_version=”4.16″ _module_preset=”default” body_font=”Open Sans||||||||” body_text_color=”#000000″ border_width_all=”0.5px” border_color_all=”#006ac1″ global_colors_info=”{}” toggle_text_color=”#000000″ toggle_font=”Open Sans|700|||||||” toggle_font_size=”18px” open=”off”]<\/p>\n The vast preponderance of genetic risk for diabetes mellitus (at >400 risk loci) maps to non-coding DNA, mostly in presumptive regulatory regions. In other cell systems such as neurons, licensing and decommissioning of thousands of cis-regulatory enhancer elements mediates postnatal maturation. Whether in neurons or islets, we still lack understanding of the target genes of most of these enhancers, and of their dynamic age-dependent regulation. Recent developments by Dr. Bevacqua, including CRISPR-based systems to study non-coding regulatory sequences in primary non-dividing cells (Bevacqua et al. 2021a) and CUT&RUN -Cleavage Under Targets and Release Using Nucleases- from low cell inputs, such as those available from human islets (Bevacqua et al. 2021b) introduce unprecedented possibilities to identify and study the function of these regulatory elements in a bona fide islet context. Identification of enhancer regions that are differentially accessible throughout islet maturation and disease will contribute to our understanding of the genetic and epigenetic mechanisms that contribute to islet \u03b2-cell dysfunction in diabetes.<\/p>\n [\/et_pb_accordion_item][et_pb_accordion_item title=”Project 3. Elucidating external signals regulating pancreatic islet maturation.” open_toggle_text_color=”#000000″ open_toggle_background_color=”#FFFFFF” closed_toggle_background_color=”#FFFFFF” icon_color=”#006ac1″ use_icon_font_size=”on” _builder_version=”4.16″ _module_preset=”default” body_font=”Open Sans||||||||” body_text_color=”#000000″ border_width_all=”0.5px” border_color_all=”#006ac1″ global_colors_info=”{}” toggle_text_color=”#000000″ toggle_font=”Open Sans|700|||||||” open=”off”]<\/p>\n Postnatal maturation of human islet cells occurs over a prolonged period from birth to early adulthood, developmental stages that coincide with changes in diet, nutrient metabolism, and hormone levels. However, the signaling basis of this fascinating example of cellular development remains poorly understood. Based on recent publications identifying differential regulation of feeding-induced enhancers with age in human islet cells, we hypothesize that nutrient- and hormone-linked islet enhancers might be enriched for motifs recognized by TFs that show differential expression with age, including those \u201cpriming\u201d functional islet maturation. We plan to study these mechanisms using reverse genetics in primary human islets and mouse models with mutations in signal-linked-TF binding motifs, combined with exposure to environmental stimuli. These studies could provide valuable information about how to generate functionally mature \u03b2-cells and to restore function to diseased \u03b2-cells.<\/p>\n [\/et_pb_accordion_item][et_pb_accordion_item title=”Project 4. Development of novel in vitro and in vivo genomic approaches to reverse diabetes.” open_toggle_text_color=”#000000″ open_toggle_background_color=”#FFFFFF” closed_toggle_background_color=”#FFFFFF” icon_color=”#006ac1″ use_icon_font_size=”on” _builder_version=”4.16″ _module_preset=”default” body_font=”Open Sans||||||||” body_text_color=”#000000″ border_width_all=”0.5px” border_color_all=”#006ac1″ global_colors_info=”{}” toggle_text_color=”#000000″ toggle_font=”Open Sans|700|||||||” open=”off”]<\/p>\n Technological advances foster discovery. We are currently developing novel CRISPR approaches, including using electroporation of ribonucleoproteins (RNPs) to delete non-coding regulatory DNA elements, without integration of lenti-vectors. This approach has multiple advantages, including simplicity, scalability, avoidance of lentiviral integration or toxicity, and adaptation for multiplexing, relevant to diabetes modeling. In addition, we are working to adapt additional dCas9- based approaches, that will allow the study of epigenetic mechanisms relevant to maturation and disease.<\/p>\n [\/et_pb_accordion_item][\/et_pb_accordion][\/et_pb_column][\/et_pb_row][et_pb_row disabled_on=”on|on|on” _builder_version=”4.16″ _module_preset=”default” disabled=”on” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Project 1″ _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”16px” global_colors_info=”{}”]<\/p>\n Project 1. Identification of transcription factors and pathways driving pancreatic islet maturation.<\/strong><\/p>\n Transcription factors (TFs) play a critical role in regulating \u03b2-cell maturation, as evidenced by studies of human monogenic diabetes mellitus, and impaired \u03b2-cell function resulting from mutations in multiple TF genes. In recent years, many human-specific TFs differentially expressed across development and disease states were identified, reflecting efforts to reliably procure human islets for research, and advances in NGS-based technologies for small cell number samples. Using genetic systems in primary human pseudoislets, the Bevacqua lab studies mechanisms regulated by TFs dynamically expressed in human islet b- and a-cells. We hypothesize that TFs showing dynamic expression during a critical window of developmental maturation, and linked to diabetes disease risk, could drive the maturation of these cells. Our studies should elucidate new genetic and chromatin regulatory networks that govern human islet cell function, and provide a much-sought \u2018roadmap\u2019 for guiding current world-wide islet cell replacement and regeneration efforts.<\/p>\n [\/et_pb_text][et_pb_text admin_label=”Project 2″ _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”16px” global_colors_info=”{}”]<\/p>\n Project 2. Deciphering non-coding regulatory mechanisms driving islet cell maturation and dysregulation.<\/strong><\/p>\n The vast preponderance of genetic risk for diabetes mellitus (at >400 risk loci) maps to non-coding DNA, mostly in presumptive regulatory regions. In other cell systems such as neurons, licensing and decommissioning of thousands of cis-regulatory enhancer elements mediates postnatal maturation. Whether in neurons or islets, we still lack understanding of the target genes of most of these enhancers, and of their dynamic age-dependent regulation. Recent developments by Dr. Bevacqua, including CRISPR-based systems to study non-coding regulatory sequences in primary non-dividing cells (Bevacqua et al. 2021a) and CUT&RUN -Cleavage Under Targets and Release Using Nucleases- from low cell inputs, such as those available from human islets (Bevacqua et al. 2021b) introduce unprecedented possibilities to identify and study the function of these regulatory elements in a bona fide islet context. Identification of enhancer regions that are differentially accessible throughout islet maturation and disease will contribute to our understanding of the genetic and epigenetic mechanisms that contribute to islet \u03b2-cell dysfunction in diabetes.<\/p>\n [\/et_pb_text][et_pb_text admin_label=”Project 3″ _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”16px” global_colors_info=”{}”]<\/p>\n Project 3. Elucidating external signals regulating pancreatic islet maturation.<\/strong><\/p>\n Postnatal maturation of human islet cells occurs over a prolonged period from birth to early adulthood, developmental stages that coincide with changes in diet, nutrient metabolism, and hormone levels. However, the signaling basis of this fascinating example of cellular development remains poorly understood. Based on recent publications identifying differential regulation of feeding-induced enhancers with age in human islet cells, we hypothesize that nutrient- and hormone-linked islet enhancers might be enriched for motifs recognized by TFs that show differential expression with age, including those \u201cpriming\u201d functional islet maturation. We plan to study these mechanisms using reverse genetics in primary human islets and mouse models with mutations in signal-linked-TF binding motifs, combined with exposure to environmental stimuli. These studies could provide valuable information about how to generate functionally mature \u03b2-cells and to restore function to diseased \u03b2-cells.<\/p>\n [\/et_pb_text][et_pb_text admin_label=”Project 4″ _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”16px” global_colors_info=”{}”]<\/p>\n Project 4. Development of novel in vitro<\/em> and in vivo<\/em> genomic approaches to reverse diabetes.<\/strong><\/p>\n Technological advances foster discovery. We are currently developing novel CRISPR approaches, including using electroporation of ribonucleoproteins (RNPs) to delete non-coding regulatory DNA elements, without integration of lenti-vectors. This approach has multiple advantages, including simplicity, scalability, avoidance of lentiviral integration or toxicity, and adaptation for multiplexing, relevant to diabetes modeling. In addition, we are working to adapt additional dCas9- based approaches, that will allow the study of epigenetic mechanisms relevant to maturation and disease.<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Team Section” module_id=”team” module_class=”team-section” _builder_version=”4.16″ _module_preset=”default” background_color=”#edf1ff” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=” title Text” _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#0C71C3″ text_font_size=”22px” global_colors_info=”{}”]<\/p>\n Current Members<\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Section” _builder_version=”4.16″ _module_preset=”default” background_color=”#edf1ff” global_colors_info=”{}”][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ _module_preset=”default” collapsed=”off” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bevacqualab\/wp-content\/uploads\/sites\/467\/2023\/02\/team-bevacqua.jpg” title_text=”team-bevacqua” admin_label=”Image” _builder_version=”4.16″ _module_preset=”default” animation_style=”fade” border_radii=”on|6px|6px|6px|6px” box_shadow_style=”preset3″ box_shadow_vertical=”-6px” box_shadow_blur=”12px” box_shadow_color=”rgba(0,0,0,0.2)” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Dr Romina Bevacqua” _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”16px” global_colors_info=”{}”]<\/p>\n Dr Romina Bevacqua, Assistant Professor<\/strong><\/p>\n Department of Medicine, Division of Endocrinology, Diabetes and Bone Disease<\/em> [\/et_pb_text][et_pb_text admin_label=”Dr Romina Bio” _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”16px” global_colors_info=”{}”]<\/p>\n Dr. Romina Bevacqua is an Assistant Professor in the Department of Medicine, Division of Endocrinology, Diabetes and Bone Disease, and member of the Diabetes, Obesity and Metabolism Institute (DOMI) and the Regenerative Biology and Stem Cell Institute, at Mount Sinai.<\/p>\n Dr. Bevacqua received her PhD in Buenos Aires University, Argentina. As a postdoctoral fellow in the laboratory of Professor Seung Kim, at Stanford University, her research focused on human islet biology.<\/p>\n Her research career vision is to perform transformative research on human diabetes, with the specific goal of expanding and improving human pancreatic beta cell mass function for the 400+ million people in the world with diabetes.<\/p>\n Contact: romina.bevacqua@mssm.edu<\/a><\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ _module_preset=”default” collapsed=”off” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bevacqualab\/wp-content\/uploads\/sites\/467\/2023\/05\/Merheb_Emilio_Portraits_2021_4_21_10-scaled.jpg” title_text=”Merheb_Emilio_Portraits_2021_4_21_10″ admin_label=”Image” _builder_version=”4.16″ _module_preset=”default” animation_style=”fade” border_radii=”on|6px|6px|6px|6px” box_shadow_style=”preset3″ box_shadow_vertical=”-6px” box_shadow_blur=”12px” box_shadow_color=”rgba(0,0,0,0.2)” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”Dr Emilio Merheb” _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”16px” global_colors_info=”{}”]<\/p>\n Dr Emilio Merheb, Senior Associate Researcher<\/span> Department of Medicine, Division of Endocrinology, Diabetes and Bone Disease<\/em> [\/et_pb_text][et_pb_text admin_label=”Dr Emilio Merheb” _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”16px” global_colors_info=”{}”]<\/p>\n Emilio Merheb<\/strong> was born and raised in Byblos, Lebanon. At the age of eighteen, he was offered a scholarship to pursue his undergraduate degree at the Lebanese American University. He completed his PhD and postdoctoral training at Albert Einstein College of Medicine, where his work focused on investigating the mechanism of a rare neurodegenerative disease, Pol III-related Leukodystrophy. Notably, his work was published in high impact peer reviewed journals, including PNAS, Cell Metabolism and Cells<\/em>. Emilio\u2019s dedication to science paid off with multiple awards including the Julius Marmur Award and the Graduate Student Council Service Award.\u00a0 In his free time, he enjoys sports, music and spending time with his family and friends.<\/p>\n <\/p>\n Contact: emilio.merheb@mssm.edu<\/a><\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_5,3_5″ _builder_version=”4.16″ _module_preset=”default” collapsed=”off” global_colors_info=”{}”][et_pb_column type=”2_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bevacqualab\/wp-content\/uploads\/sites\/467\/2023\/05\/Merheb_Emilio_Portraits_2021_4_21_10-scaled.jpg” title_text=”Merheb_Emilio_Portraits_2021_4_21_10″ admin_label=”Image” _builder_version=”4.16″ _module_preset=”default” animation_style=”fade” border_radii=”on|6px|6px|6px|6px” box_shadow_style=”preset3″ box_shadow_vertical=”-6px” box_shadow_blur=”12px” box_shadow_color=”rgba(0,0,0,0.2)” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”3_5″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=”PhD student Victoria Huhn” _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”16px” global_colors_info=”{}”]<\/p>\n Dr Emilio Merheb, Senior Associate Researcher<\/span> Department of Medicine, Division of Endocrinology, Diabetes and Bone Disease<\/em> [\/et_pb_text][et_pb_text admin_label=”Text” _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”16px” global_colors_info=”{}”]<\/p>\n Emilio Merheb<\/strong> was born and raised in Byblos, Lebanon. At the age of eighteen, he was offered a scholarship to pursue his undergraduate degree at the Lebanese American University. He completed his PhD and postdoctoral training at Albert Einstein College of Medicine, where his work focused on investigating the mechanism of a rare neurodegenerative disease, Pol III-related Leukodystrophy. Notably, his work was published in high impact peer reviewed journals, including PNAS, Cell Metabolism and Cells<\/em>. Emilio\u2019s dedication to science paid off with multiple awards including the Julius Marmur Award and the Graduate Student Council Service Award.\u00a0 In his free time, he enjoys sports, music and spending time with his family and friends.<\/p>\n <\/p>\n Contact: emilio.merheb@mssm.edu<\/a><\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Publications Section” module_id=”publications” module_class=”publications-section” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=” title Text” _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#0C71C3″ text_font_size=”22px” global_colors_info=”{}”]<\/p>\n Selected Publications<\/strong><\/p>\n [\/et_pb_text][et_pb_text admin_label=”Pubs” _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”16px” global_colors_info=”{}”]<\/p>\n Rottner AK, Ye Y, Navarro-Guerrero D, Rajesh V, Pollner A, Bevacqua RJ<\/strong>, Yang J, et al. A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk.\u00a0Nature Genetics <\/em>2022; https:\/\/doi-org\/10.1038\/s41588-022-01261-2<\/p>\n https:\/\/pubmed.ncbi.nlm.nih.gov\/36543916\/<\/strong><\/a><\/p>\n Bevacqua RJ<\/strong>, Dai X, Lam JY, Gu X, Friedlander MSH, Tellez K, Miguel-Escalada I, Dominguez AA, Qi LS, Ferrer J, MacDonald PE, Kim SK. CRISPR-based gene editing in primary human pancreatic islet cells. Nature Communications<\/em> 2021;12(1):2397.<\/p>\n Perspective: A commentary by Romina Bevacqua. Behind the Paper: CRISPR-based genome editing in primary human pancreatic islet cells. Nature Portfolio Bioengineering Community. 2021. <\/em>Weblink: https:\/\/bioengineeringcommunity.nature.com\/posts\/crispr-based-genome-editing-in-primary-human-pancreatic-islet-cells<\/a><\/p>\n Highlight: Latest HIRN Science. HIRN Newsletter. April 2021. Weblink: https:\/\/myemail.constantcontact.com\/HIRN-April-2021-Newsletter.html?soid=1125971089264&aid=vYWEZRRUDTA <\/em><\/p>\n https:\/\/pubmed.ncbi.nlm.nih.gov\/33893274\/<\/a><\/strong><\/p>\n Bevacqua RJ<\/strong>, Lam JY, Peiris H, Whitener RL, Kim S, Gu X, and Kim SK. SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic b-cells. Genes and Development<\/em> 2021;35(3-4):234-249.<\/p>\n Journal Highlight: Genes and Development Cover, February 1, 2021:35(3-4)<\/em><\/p>\n https:\/\/pubmed.ncbi.nlm.nih.gov\/33446570\/<\/strong><\/a><\/p>\n Wu CT, Hilgendorf KI, Bevacqua RJ<\/strong>, Hang Y, Demeter J, Kim SK, Jackson PK. Discovery of ciliary G protein-coupled receptors regulating pancreatic islet insulin and glucagon secretion. Genes and Development<\/em> 2021;35(17-18):1243-1255.<\/p>\n https:\/\/pubmed.ncbi.nlm.nih.gov\/34385262\/<\/strong><\/a><\/p>\n Wu CT, Lidsky PV, Xiao Y, Lee IT, Cheng R, Nakayama T, Jiang S, Demeter J, Bevacqua RJ<\/strong>, Chang CA, Whitener RL, Stalder AK, Zhu B, Chen H, Goltsev Y, Tzankov A, Nayak JV, Nolan GP, Matter MS, Andino R, Jackson PK. SARS-CoV-2 infects human pancreatic \u03b2 cells and elicits \u03b2 cell impairment. Cell Metabolism<\/em> 2021;33(8):1565-1576.e5.<\/p>\n https:\/\/pubmed.ncbi.nlm.nih.gov\/34081912\/<\/strong><\/a><\/p>\n Friedlander MSH, Nguyen V, Kim S*, Bevacqua RJ<\/strong>*. Pancreatic pseudoislets: an organoid archetype for metabolism research. Diabetes<\/em> 2021;70(5):1051-1060.<\/p>\n https:\/\/pubmed.ncbi.nlm.nih.gov\/33947722\/<\/strong><\/a><\/p>\n Kim S, Whitener RL, Peiris H, Gu X, Chang CA, Lam JY, Camunas-Soler J, Park I, Bevacqua RJ<\/strong>, Tellez K, Quake SR, Lakey JRT, Bottino R, Ross PJ, Kim SK. Molecular and genetic regulation of pig pancreatic islet cell development. Development<\/em> 2020;147(6):dev186213.<\/p>\n Journal Highlight: Pancreatic development in the pig. <\/em>Development 2020;147(6):e0604.<\/em><\/p>\n https:\/\/pubmed.ncbi.nlm.nih.gov\/32108026\/<\/strong><\/a><\/p>\n <\/p>\n [\/et_pb_text][et_pb_button button_url=”https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/romina.bevacqua.1\/bibliography\/public\/” url_new_window=”on” button_text=”Complete List of Published Work” button_alignment=”center” _builder_version=”4.16″ _module_preset=”default” custom_button=”on” button_text_color=”#FFFFFF” button_bg_color=”#006ac1″ button_border_width=”0px” button_border_radius=”4px” background_layout=”dark” global_colors_info=”{}”][\/et_pb_button][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Funding and awards Section” module_id=”funding” module_class=”funding-section” _builder_version=”4.16″ _module_preset=”default” background_image=”https:\/\/labs.icahn.mssm.edu\/bevacqualab\/wp-content\/uploads\/sites\/467\/2023\/02\/Bevacqua-Banner2.jpg” parallax=”on” parallax_method=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=” title Text” _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#FFFFFF” text_font_size=”22px” global_colors_info=”{}”]<\/p>\n Funding and Awards<\/strong><\/p>\n [\/et_pb_text][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” global_colors_info=”{}”]<\/p>\n 2023 <\/strong>NIDDK-HIRN CHIB New Investigator Gateway Awards for Collaborative T1D Research (R03)<\/p>\n 2023<\/strong> Biomedical Laureate<\/p>\n https:\/\/www.mountsinai.org\/about\/newsroom\/2022\/icahn-school-of-medicine-at-mount-sinai-continues-drive-to-diversify-research-by-appointing-new-biomedical-laureates<\/a><\/p>\n 2018-2021<\/strong> JDRF Postdoctoral Scholar<\/p>\n [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bevacqualab\/wp-content\/uploads\/sites\/467\/2023\/03\/Bevacqua-Banner.jpg” title_text=”Bevacqua-Banner” _builder_version=”4.16″ _module_preset=”default” animation_style=”fade” border_radii=”on|6px|6px|6px|6px” global_colors_info=”{}”][\/et_pb_image][et_pb_divider color=”#006ac1″ divider_position=”center” divider_weight=”0.5px” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Positions Section” module_id=”positions” module_class=”positions-section” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text admin_label=” title Text” _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#0C71C3″ text_font_size=”22px” global_colors_info=”{}”]<\/p>\n Positions<\/strong><\/p>\n [\/et_pb_text][et_pb_text admin_label=”text” _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_font_size=”16px” global_colors_info=”{}”]<\/p>\n The Bevacqua Lab is always interested in hearing from curious, motivated potential students, post-doctoral trainees and research associates who are excited in transformative research on human diabetes and pancreatic islet biology.<\/p>\n Formal announcements of positions will be posted here in due course but informal enquires are welcome anytime. Please send your CV and a covering letter outlining your motivation for applying to romina.bevacqua@mssn.edu.<\/p>\n Current Open Positions<\/strong><\/p>\n We are currently looking for a Postdoc and Grad Student to join the lab. Email Dr. Bevacqua if interested! [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_gallery gallery_ids=”175,176,177″ gallery_orderby=”rand” _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_gallery][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Footer Section” _builder_version=”4.16″ _module_preset=”default” background_color=”#000000″ global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.16″ _module_preset=”default” text_font=”Open Sans||||||||” text_text_color=”#FFFFFF” text_font_size=”16px” global_colors_info=”{}”]<\/p>\n The Bevacqua Lab<\/strong><\/p>\n [\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ specialty=”on” disabled_on=”on|on|on” _builder_version=”4.16″ _module_preset=”default” background_color=”#edf1ff” disabled=”on” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][\/et_pb_column][et_pb_column type=”3_4″ specialty_columns=”3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_row_inner _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_column_inner saved_specialty_column_type=”3_4″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_toggle title=”PubMed” open_toggle_background_color=”#FFFFFF” closed_toggle_background_color=”#FFFFFF” icon_color=”#006ac1″ open_icon_color=”#006ac1″ _builder_version=”4.16″ _module_preset=”default” body_font=”Open Sans||||||||” border_radii=”on|6px|6px|6px|6px” border_width_all=”0.5px” border_color_all=”#006ac1″ global_colors_info=”{}”]<\/p>\n https:\/\/pubmed.ncbi.nlm.nih.gov\/33893274\/<\/strong><\/a> [\/et_pb_toggle][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=”1_3,1_3,1_3″ disabled_on=”on|on|on” _builder_version=”4.16″ _module_preset=”default” disabled=”on” global_colors_info=”{}”][et_pb_column_inner 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global_colors_info=”{}”][\/et_pb_button][\/et_pb_column_inner][\/et_pb_row_inner][\/et_pb_column][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" Our ResearchThe Bevacqua Lab studies human diabetes, with the goal of expanding and improving human pancreatic beta cell mass function for the 400+ million people in the world with diabetes. More specifically, we focus on pancreatic islet biology, attempting to understand the regulatory mechanisms driving postnatal human islet maturation and the genetic basis for their […]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-3","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/bevacqualab\/wp-json\/wp\/v2\/pages\/3","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/bevacqualab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/bevacqualab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/bevacqualab\/wp-json\/wp\/v2\/users\/545"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/bevacqualab\/wp-json\/wp\/v2\/comments?post=3"}],"version-history":[{"count":62,"href":"https:\/\/labs.icahn.mssm.edu\/bevacqualab\/wp-json\/wp\/v2\/pages\/3\/revisions"}],"predecessor-version":[{"id":200,"href":"https:\/\/labs.icahn.mssm.edu\/bevacqualab\/wp-json\/wp\/v2\/pages\/3\/revisions\/200"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/bevacqualab\/wp-json\/wp\/v2\/media?parent=3"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}![\"\"](\"https:\/\/labs.icahn.mssm.edu\/bevacqualab\/wp-content\/uploads\/sites\/467\/2023\/02\/B-Image-1.jpg\")
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<\/p>\n
Member of the Diabetes Obesity Metabolism Institute and the Regenerative Biology and Stem Cell Institute<\/em><\/p>\n
<\/strong><\/p>\n
Member of the Diabetes Obesity Metabolism Institute and the Regenerative Biology and Stem Cell Institute<\/em><\/p>\n
<\/strong><\/p>\n
Member of the Diabetes Obesity Metabolism Institute and the Regenerative Biology and Stem Cell Institute<\/em><\/p>\n
<\/em><\/p>\n
https:\/\/pubmed.ncbi.nlm.nih.gov\/33446570\/<\/strong><\/a>
https:\/\/pubmed.ncbi.nlm.nih.gov\/36543916\/<\/strong><\/a>
https:\/\/pubmed.ncbi.nlm.nih.gov\/34385262\/<\/strong><\/a>
https:\/\/pubmed.ncbi.nlm.nih.gov\/34081912\/<\/strong><\/a>
https:\/\/pubmed.ncbi.nlm.nih.gov\/33947722\/<\/strong><\/a>
https:\/\/pubmed.ncbi.nlm.nih.gov\/32108026\/<\/strong><\/a><\/p>\n