{"id":5226,"date":"2023-10-19T19:00:54","date_gmt":"2023-10-19T23:00:54","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/bernsteinlab2\/?page_id=5226"},"modified":"2024-09-13T10:12:30","modified_gmt":"2024-09-13T14:12:30","slug":"lab-events","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/lab-events\/","title":{"rendered":"Lab Events"},"content":{"rendered":"

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Lab Events<\/span><\/strong><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Section 27 – Two Column – Title Over Text Over Button Next to Image” module_class=”section27_two_column_title_over_txt_over_btn_next_to_img” _builder_version=”4.9.0″ _module_preset=”default” background_enable_image=”off” parallax=”on” parallax_method=”off” custom_padding=”||16px|||” locked=”off” collapsed=”off”][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”9px|||||” animation_style=”fade” animation_duration=”700ms”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”20px” header_font_size=”25px” hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n

AUGUST 2024<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.0″ _module_preset=”default” background_enable_image=”off” custom_padding=”0px|||||”][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”0px|||||”][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”20px” custom_margin=”109px|118px||||” custom_padding=”|42px||||” hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n

Congratulations to Aliana Guzman for a successful summer of cancer research in the TCI SPARKED (Summer Program Advancing Research Knowledge and Education for Diversity) program. She was mentored by Elena Grossi, PhD.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-content\/uploads\/sites\/498\/2024\/09\/IMG_1826-261×300.png” title_text=”IMG_1826″ _builder_version=”4.9.0″ _module_preset=”default” width=”172.9%” custom_margin=”|-30px||-291px||” custom_padding=”|||252px||” hover_enabled=”0″ sticky_enabled=”0″][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”9px|||||” animation_style=”fade” animation_duration=”700ms”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” header_font_size=”25px” hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n

MAY 2024<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”0px|||||”][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”20px” custom_margin=”109px|118px||||” custom_padding=”|42px||||”]<\/p>\n

Anisha defended her thesis with flying colors in May 2024, entitled, “The role of ATRX in-frame fusions in neuroblastoma cell states<\/em>“<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-content\/uploads\/sites\/498\/2024\/09\/Anisha-Defense-245×300.jpg” title_text=”Anisha Defense” _builder_version=”4.9.0″ _module_preset=”default” width=”172.9%” custom_margin=”|-30px||-291px||” custom_padding=”|||252px||” hover_enabled=”0″ sticky_enabled=”0″][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”9px|||||” animation_style=”fade” animation_duration=”700ms”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” header_font_size=”25px”]<\/p>\n

SEPTEMBER 2023<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”0px|||||”][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”20px” custom_margin=”-2px|118px||||” custom_padding=”71px|42px||||”]<\/p>\n

Congratulations to\u00a0Dr. Dan Filipescu and team on a\u00a0new publication in Nature Cell Biology! This publication highlights a role for macroH2A in the melanoma tumor microenvironment.\u00a0A tour de force study involving mouse modeling, immunology, and stromal biology.\u00a0Read the article\u00a0here<\/a>.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-content\/uploads\/sites\/498\/2024\/08\/lAB-EVENT.jpg” title_text=”lAB EVENT” _builder_version=”4.9.0″ _module_preset=”default” width=”170%” custom_margin=”|||-208px||” custom_padding=”|||96px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”9px|||||” animation_style=”fade” animation_duration=”700ms”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” header_font_size=”25px”]<\/p>\n

APRIL 2022<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”20px” custom_margin=”27px|118px||||” custom_padding=”|42px||||”]<\/p>\n

Congratulations to Saul Carcamo, Christie Nguyen, and members of the Bernstein lab for their finding that ARID2 loss in melanoma results in defective assembly of the\u00a0PBAF complex, altering BAF genomic occupancy with consequences on chromatin accessibility, transcription factor binding, and transcriptional changes that promote metastasis. Read the article published in Cell Reports\u00a0here<\/a>.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-content\/uploads\/sites\/498\/2023\/10\/Events.png” title_text=”Events” _builder_version=”4.9.0″ _module_preset=”default” width=”170%” custom_margin=”|||-208px||” custom_padding=”|105px||96px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”9px|||||” animation_style=”fade” animation_duration=”700ms”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” header_font_size=”25px”]<\/p>\n

MARCH 2022<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”20px” custom_margin=”25px|118px||||” custom_padding=”|42px||||”]<\/p>\n

We are so proud of Christie Nguyen for an impeccable and successful thesis defense \u2018Altered transcription factor dynamics in PBAF-deficient melanoma\u2019!<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-content\/uploads\/sites\/498\/2023\/10\/Christie.png” title_text=”Christie” _builder_version=”4.9.0″ _module_preset=”default” width=”170%” custom_margin=”-39px|||-208px||” custom_padding=”|||96px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”9px|||||” animation_style=”fade” animation_duration=”700ms”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” header_font_size=”25px”]<\/p>\n

MARCH 2021<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”16px|||||”][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”20px” custom_margin=”41px|118px||||” custom_padding=”|42px||||”]<\/p>\n

Congratulations to Dr. Saul Carcamo on his outstanding thesis defense focused on SWI\/SNF subcomplex dynamics in malignant melanoma!<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-content\/uploads\/sites\/498\/2023\/10\/Saul.png” title_text=”Saul” _builder_version=”4.9.0″ _module_preset=”default” width=”170%” custom_margin=”-27px|||-208px||” custom_padding=”0px|||96px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”9px|||||” animation_style=”fade” animation_duration=”700ms”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” header_font_size=”25px”]<\/p>\n

FEBRUARY 2021<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default” custom_margin=”-20px|auto||auto||” custom_padding=”0px|||||”][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”20px” custom_margin=”54px|118px||||” custom_padding=”|42px||||”]<\/p>\n

Congratulations to Drs. Fl\u00e1via Ghiraldini and Dan Filipescu on their comprehensive review of histone variants and their chaperones in the pathogenesis of solid cancers. Read the article published in Nature Reviews, Cancer\u00a0here<\/a>.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-content\/uploads\/sites\/498\/2023\/10\/Nature-Reviews.jpg” title_text=”Nature Reviews” _builder_version=”4.9.0″ _module_preset=”default” width=”170%” custom_margin=”|||-208px||” custom_padding=”0px|||96px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”9px||8px|||” animation_style=”fade” animation_duration=”700ms”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” header_font_size=”25px”]<\/p>\n

OCTOBER 2019<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”20px” custom_margin=”4px|118px||||” custom_padding=”|42px||||”]<\/p>\n

Congratulations to Zulehka Qadeer and members of the Bernstein lab for their finding that that neuroblastoma in older children and adolescents harboring large deletions within the ATRX gene may be responsive to EZH2 inhibitor targeted therapy.\u00a0The team found that EZH2 and REST cooperate to block genes responsible for neuron development, and EZH2 inhibition induces killing of ATRX altered neuroblastoma cells. Read the article published in Cancer Cell\u00a0here<\/a>.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-content\/uploads\/sites\/498\/2023\/10\/Cancer-Cell.jpg” title_text=”Cancer Cell” _builder_version=”4.9.0″ _module_preset=”default” width=”170%” custom_margin=”|||-208px||” custom_padding=”|||96px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”9px|||||” animation_style=”fade” animation_duration=”700ms”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” header_font_size=”25px” custom_padding=”44px|||||”]<\/p>\n

OCTOBER 2018<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”20px” custom_margin=”29px|118px||||” custom_padding=”|42px||||”]<\/p>\n

Congrats to Zhen Sun, Dan Filipescu and colleagues for identifying the mechanism underlying de novo macroH2A histone variant deposition! This study showed\u00a0that histone variant macroH2A is deposited across the mouse genome and subsequently pruned from transcriptionally active regions to establish macroH2A chromatin domains. Read the article published in Nature Structural & Molecular Biology\u00a0here<\/a>.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-content\/uploads\/sites\/498\/2023\/10\/Nature-Cover-226×300.png” title_text=”Nature Cover” _builder_version=”4.9.0″ _module_preset=”default” width=”170%” custom_margin=”|||-208px||” custom_padding=”|||96px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”9px||35px|||” animation_style=”fade” animation_duration=”700ms”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” header_font_size=”25px”]<\/p>\n

SEPTEMBER 2018<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”2px|||||”][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”20px” custom_margin=”35px|118px||||” custom_padding=”|42px||2px||”]<\/p>\n

Congratulations to Dr. Zhen Sun on his outstanding thesis defense!<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-content\/uploads\/sites\/498\/2023\/10\/Zhen.jpg” title_text=”Zhen” _builder_version=”4.9.0″ _module_preset=”default” width=”170%” custom_margin=”|70px||-208px||” custom_padding=”|3px|0px|96px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”9px|||||” animation_style=”fade” animation_duration=”700ms”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” header_font_size=”25px”]<\/p>\n

AUGUST 2018<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”20px” custom_margin=”-2px|118px||||” custom_padding=”|42px||||”]<\/p>\n

Congratulations to Thomas Strub and members of the Bernstein lab for their discovery of the HDAC SIRT6 in BRAF-mutant melanoma as a novel epigenetic regulator of resistance to BRAF and MEK inhibitors. This work also identified IGFBP2 as a potential biomarker for MAPKi resistance. Read the article published in Nature Communications\u00a0here<\/a>.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-content\/uploads\/sites\/498\/2023\/10\/Nat-Comm.png” title_text=”Nat Comm” _builder_version=”4.9.0″ _module_preset=”default” width=”170%” custom_margin=”|||-208px||” custom_padding=”|||96px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”9px||1px|||” animation_style=”fade” animation_duration=”700ms”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” header_font_size=”25px”]<\/p>\n

NOVEMBER 2017<\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”20px” custom_margin=”-2px|118px||||” custom_padding=”|42px||||”]<\/p>\n

Congratulations to Dan Hasson and the Bernstein & Hernando teams for their discovery of AMIGO2 as a survival gene and potential therapeutic target for metastatic melanoma. Read the article published in Molecular Cell\u00a0here<\/a>. This work was published Nov. 16, 2017 and made the cover!<\/p>\n

Cover Image:\u00a0<\/em>An artistic representation of a genomic Self-Organizing Map, which displays the enrichment patterns of histone H3 acetylated at lysine 27 (H3K27ac) marking active regulatory regions in metastatic melanoma. In this issue of Molecular Cell, Fontanals-Cirera and Hasson et al. (pp. 731\u2013744) mapped the melanoma enhancer landscape and identified AMIGO2 and its interactor PTK7 as a therapeutically targetable axis to inhibit melanoma cell survival. They further demonstrate that AMIGO2 is regulated by \u201csuper-enhancers\u201d acquired during melanoma pathogenesis. Mosaic work by Dan Hasson. Photographed by Maru Teppei.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-content\/uploads\/sites\/498\/2023\/10\/Molecular-Cell-Cover.jpg” title_text=”Molecular Cell Cover” _builder_version=”4.9.0″ _module_preset=”default” width=”170%” custom_margin=”|||-208px||” custom_padding=”|430px||96px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”9px|||||” animation_style=”fade” animation_duration=”700ms”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” header_font_size=”25px”]<\/p>\n

JUNE 2017<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”0px||0px|||”][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”20px” custom_margin=”19px|118px||||” custom_padding=”|42px||||”]<\/p>\n

Congratulations to Dr. Zulekha Qadeer on her outstanding thesis defense!<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-content\/uploads\/sites\/498\/2023\/10\/Zu-graduation-II.jpg” title_text=”Zu-graduation-II” _builder_version=”4.9.0″ _module_preset=”default” width=”170%” custom_margin=”||61px|-208px||” custom_padding=”|||136px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”9px|||||” animation_style=”fade” animation_duration=”700ms”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” header_font_size=”25px”]<\/p>\n

MARCH 2017<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default” custom_margin=”-63px|auto||auto||”][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”20px” custom_margin=”40px|118px||||” custom_padding=”|42px||||”]<\/p>\n

Congratulations to Maddy who successfully \u2018matched\u2019 at ISMMS for a Dermatology residency! She will join our program in July 2018. Madeleine earned here undergraduate degree in Mathematics at Lafayette College. Between her 3rd and 4th year of medical school, she spent the year studying melanoma epigenetics in the Bernstein laboratory.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-content\/uploads\/sites\/498\/2023\/10\/gantz.jpg” title_text=”gantz” _builder_version=”4.9.0″ _module_preset=”default” width=”170%” custom_margin=”|||-208px||” custom_padding=”|||96px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”9px|||||” animation_style=”fade” animation_duration=”700ms”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” header_font_size=”25px”]<\/p>\n

JULY 2016<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”0px|||||”][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”20px” custom_margin=”33px|118px||||” custom_padding=”|42px||||”]<\/p>\n

Congratulations to Jay Chung, Zhen Sun & Alex Gaspar-Maia on their publication in Cell Reports! Read the article\u00a0here<\/a>.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-content\/uploads\/sites\/498\/2023\/10\/sliderChung-etal2016-Final.jpg” title_text=”sliderChung-etal2016-Final” _builder_version=”4.9.0″ _module_preset=”default” width=”170%” custom_margin=”|||-208px||” custom_padding=”|||96px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_margin=”|auto|-61px|auto||” custom_padding=”9px|||||” animation_style=”fade” animation_duration=”700ms”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” header_font_size=”25px”]<\/p>\n

MAY 2016<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”20px” custom_margin=”14px|118px||||” custom_padding=”|42px||||”]<\/p>\n

Congratulations to Dr. Jay Chung for successfully defending his thesis!<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-content\/uploads\/sites\/498\/2023\/10\/Jay_FullSizeRender-300×225-1.jpg” title_text=”Jay_FullSizeRender-300×225″ _builder_version=”4.9.0″ _module_preset=”default” width=”170%” custom_margin=”|||-208px||” custom_padding=”|||96px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”9px|||||” animation_style=”fade” animation_duration=”700ms”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” header_font_size=”25px”]<\/p>\n

APRIL 2016<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”0px|||||”][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”20px” custom_margin=”57px|118px||||” custom_padding=”|42px||||”]<\/p>\n

Congratulations to David Valle-Garcia!\u00a0His paper \u2018ATRX binds to atypical chromatin domains at the 3\u2032 exons of zinc finger genes to preserve H3K9me3 enrichment\u2019 has been published in Epigenetics. Read the article\u00a0here<\/a>.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-content\/uploads\/sites\/498\/2023\/10\/David-Valle.jpg” title_text=”David-Valle” _builder_version=”4.9.0″ _module_preset=”default” width=”170%” custom_margin=”|||-208px||” custom_padding=”|||96px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”20px” custom_margin=”42px|118px||||” custom_padding=”|42px||||”]<\/p>\n

PhD candidate Zulekha Qadeer speaks about her neuroblastoma work funded by St. Baldrick\u2019s Foundation at the\u00a0Northport fundraising event on Friday, March 11.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-content\/uploads\/sites\/498\/2023\/10\/Z_event.png” title_text=”Z_event” _builder_version=”4.9.0″ _module_preset=”default” width=”170%” custom_margin=”|||-208px||” custom_padding=”|354px|26px|96px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”9px|||||” animation_style=”fade” animation_duration=”700ms”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” header_font_size=”25px”]<\/p>\n

MARCH 2016<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”0px|||||”][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font_size=”20px” custom_margin=”49px|118px||||” custom_padding=”|42px||||”]<\/p>\n

Congrats to Zu!\u00a0Zulekha Qadeer awarded the Department of Defense Horizon Award for her proposal entitled \u201cInvestigating the Mechanisms Underlying ATRX Mutant Neuroblastoma\u201d.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-content\/uploads\/sites\/498\/2023\/10\/Zulekha.png” title_text=”Zulekha” _builder_version=”4.9.0″ _module_preset=”default” width=”170%” custom_margin=”|||-208px||” custom_padding=”|||96px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.0″ _module_preset=”default” custom_margin=”||-91px|||”][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_margin=”-79px|auto||auto||”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_divider color=”#141414″ _builder_version=”4.9.0″ _module_preset=”default”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Footer Fullwidth – Section 13″ module_class=”footer-section” _builder_version=”4.9.0″ background_color=”#FFFFFF” use_background_color_gradient=”on” background_color_gradient_start=”#ffffff” background_color_gradient_end=”#ffffff” background_image=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab2\/wp-content\/uploads\/sites\/498\/2022\/10\/Rectangle-3.png” background_enable_image=”off” max_width=”100%” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|phone” module_alignment=”center” custom_margin=”100px|||176px|false|false” custom_padding=”3px|0px|0px|0px|false|false” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”14%” animation_starting_opacity=”100%” saved_tabs=”all” locked=”off” collapsed=”on”][et_pb_row _builder_version=”4.9.0″ background_color=”#FFFFFF” background_color_gradient_direction=”38deg” module_alignment=”center” custom_margin=”|auto||147px||” custom_padding=”98px|||||” locked=”off” collapsed=”on”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_social_media_follow icon_color=”#00AEEF” _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” text_orientation=”center” custom_margin=”||17px|||”][et_pb_social_media_follow_network social_network=”twitter” url=”https:\/\/twitter.com\/bernstein_lab” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on” follow_button=”off” url_new_window=”on”]twitter[\/et_pb_social_media_follow_network][\/et_pb_social_media_follow][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_text_color=”#FFFFFF” text_font_size=”24px”]<\/p>\n

Contact Us<\/strong><\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.9.0″ background_color=”#FFFFFF” background_color_gradient_direction=”38deg” module_alignment=”center” custom_margin=”|auto|-2px|auto||” custom_padding=”0px||104px|||” locked=”off” collapsed=”on”][et_pb_column type=”1_3″ _builder_version=”4.9.0″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”22px” background_color=”#FFFFFF”]<\/p>\n

Resources<\/strong><\/a><\/span><\/p>\n

Department of Oncological Sciences<\/span><\/a>
Black Family Stem Cell Institute<\/span><\/a>
Tisch Cancer Institute<\/span><\/a>
Department of Dermatology<\/a>
Graduate School of Biomedical Sciences<\/span><\/a><\/p>\n

\"MSSMLogo\"<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.25em” header_font=”||||||||” header_4_font=”|700||on|||||” header_4_font_size=”16px” header_4_letter_spacing=”1px” header_4_line_height=”1.5em” background_color=”#FFFFFF” background_layout=”dark” locked=”off”]<\/p>\n

E-mail
<\/strong>emily.bernstein@mssm.edu<\/a><\/span><\/p>\n

Phone
<\/strong>Tel: 212-824-9335<\/p>\n

<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.25em” header_font=”||||||||” header_4_font=”|700||on|||||” header_4_font_size=”16px” header_4_letter_spacing=”1px” header_4_line_height=”1.5em” background_layout=”dark” locked=”off”]<\/p>\n

Lab Address <\/strong><\/span>
Department of Oncological Sciences<\/span>
Icahn School of Medicine at Mount Sinai<\/span>
One Gustave L. Levy Place, Box 1044A<\/span>
New York, NY 10029<\/span><\/p>\n

Administrative Assistant<\/strong><\/span>
Genevieve Joseph, PhD<\/span>
Tel: 212-824-9367<\/span>
E-mail:<\/span> genevieve.joseph@mssm.edu<\/a><\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Lab EventsAUGUST 2024Congratulations to Aliana Guzman for a successful summer of cancer research in the TCI SPARKED (Summer Program Advancing Research Knowledge and Education for Diversity) program. She was mentored by Elena Grossi, PhD.MAY 2024Anisha defended her thesis with flying colors in May 2024, entitled, “The role of ATRX in-frame fusions in neuroblastoma cell states”SEPTEMBER […]<\/p>\n","protected":false},"author":393,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"

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Lab Events<\/strong><\/h1>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"1_2\" _builder_version=\"4.9.0\" _module_preset=\"default\" background_color=\"RGBA(0,0,0,0)\"][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=\"1\" specialty=\"on\" admin_label=\"Timeline\" _builder_version=\"4.9.0\" background_color=\"#FFFFFF\" animation_style=\"fade\" animation_duration=\"700ms\"][et_pb_column type=\"1_3\" _builder_version=\"3.25\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_text _builder_version=\"4.9.0\" text_font=\"|600|||||||\" text_line_height=\"1.8em\" header_2_font=\"Oswald|500||on|||||\" header_2_font_size=\"80px\" header_4_font=\"Merriweather||||||||\" header_4_text_color=\"#e94558\" header_4_line_height=\"1.4em\" header_2_font_size_tablet=\"60px\" header_2_font_size_phone=\"35px\" header_2_font_size_last_edited=\"on|phone\" header_4_font_size_tablet=\"20px\" header_4_font_size_phone=\"14px\" header_4_font_size_last_edited=\"on|phone\" locked=\"off\"]<\/p>

Events<\/span><\/h4>

Over the Years<\/h2>

[\/et_pb_text][\/et_pb_column][et_pb_column type=\"2_3\" specialty_columns=\"2\" _builder_version=\"3.25\" custom_padding=\"|||\" custom_padding__hover=\"|||\"][et_pb_row_inner column_structure=\"1_2,1_2\" _builder_version=\"4.9.0\" custom_padding=\"|3px||30px|false|false\" border_color_all=\"#00AEEF\" border_width_left=\"2px\"][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_blurb title=\"September 2023\" use_icon=\"on\" font_icon=\"%%61%%\" icon_color=\"#00AEEF\" icon_placement=\"left\" content_max_width=\"100%\" use_icon_font_size=\"on\" icon_font_size=\"40px\" _builder_version=\"4.9.0\" header_level=\"h5\" header_font=\"Oswald|||on|||||\" header_text_color=\"#00AEEF\" header_line_height=\"1.4em\" body_font=\"Merriweather|700|||||||\" body_text_color=\"#000000\" body_font_size=\"20px\" body_line_height=\"1.8em\" custom_margin=\"|||-51px|false|false\" body_font_size_tablet=\"18px\" body_font_size_phone=\"16px\" body_font_size_last_edited=\"on|phone\" locked=\"off\"][\/et_pb_blurb][\/et_pb_column_inner][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_text _builder_version=\"4.9.0\" text_font=\"Arial|300|||||||\" text_font_size=\"18px\" text_line_height=\"1.8em\" width=\"150%\" max_width=\"150%\" custom_margin=\"|-426px||-187px||\" custom_padding=\"|0px||0px||\" locked=\"off\"]<\/p>

Congratulations to\u00a0Dr. Dan Filipescu and team on a\u00a0new publication in Nature Cell Biology! This publication highlights a role for macroH2A in the melanoma tumor microenvironment.\u00a0A tour de force study involving mouse modeling, immunology, and stromal biology.\u00a0Read the article\u00a0here<\/a>.<\/p>

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[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=\"1_2,1_2\" _builder_version=\"4.9.0\" custom_padding=\"|||30px|false|false\" border_color_all=\"#00AEEF\" border_width_left=\"2px\"][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_blurb title=\"April 2022\" use_icon=\"on\" font_icon=\"%%61%%\" icon_color=\"#00AEEF\" icon_placement=\"left\" content_max_width=\"100%\" use_icon_font_size=\"on\" icon_font_size=\"40px\" _builder_version=\"4.9.0\" header_level=\"h5\" header_font=\"Oswald|||on|||||\" header_text_color=\"#00AEEF\" header_line_height=\"1.4em\" body_font=\"Merriweather|700|||||||\" body_text_color=\"#000000\" body_font_size=\"20px\" body_line_height=\"1.8em\" custom_margin=\"|||-51px|false|false\" body_font_size_tablet=\"18px\" body_font_size_phone=\"16px\" body_font_size_last_edited=\"on|phone\" locked=\"off\"][\/et_pb_blurb][\/et_pb_column_inner][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_text _builder_version=\"4.9.0\" text_font=\"Arial|300|||||||\" text_font_size=\"18px\" text_line_height=\"1.8em\" width=\"150%\" max_width=\"150%\" custom_margin=\"|||-194px||\" custom_padding=\"|||0px||\" locked=\"off\"]<\/p>

Congratulations to Saul Carcamo, Christie Nguyen, and members of the Bernstein lab for their finding that ARID2 loss in melanoma results in defective assembly of the\u00a0PBAF complex, altering BAF genomic occupancy with consequences on chromatin accessibility, transcription factor binding, and transcriptional changes that promote metastasis. Read the article published in Cell Reports here<\/a>.<\/p>

\"\"<\/strong><\/p>

[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=\"1_2,1_2\" _builder_version=\"4.9.0\" custom_padding=\"|||30px|false|false\" border_color_all=\"#00AEEF\" border_width_left=\"2px\"][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_blurb title=\"March 2022\" use_icon=\"on\" font_icon=\"%%61%%\" icon_color=\"#00AEEF\" icon_placement=\"left\" content_max_width=\"100%\" use_icon_font_size=\"on\" icon_font_size=\"40px\" _builder_version=\"4.9.0\" header_level=\"h5\" header_font=\"Oswald|||on|||||\" header_text_color=\"#00AEEF\" header_line_height=\"1.4em\" body_font=\"Merriweather|700|||||||\" body_text_color=\"#000000\" body_font_size=\"20px\" body_line_height=\"1.8em\" custom_margin=\"|||-51px|false|false\" body_font_size_tablet=\"18px\" body_font_size_phone=\"16px\" body_font_size_last_edited=\"on|phone\" locked=\"off\"][\/et_pb_blurb][\/et_pb_column_inner][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_text _builder_version=\"4.9.0\" text_font=\"Arial|300|||||||\" text_font_size=\"18px\" text_line_height=\"1.8em\" width=\"150%\" max_width=\"150%\" custom_margin=\"|199px||-223px||\" custom_padding=\"|||25px||\" locked=\"off\"]<\/p>

We are so proud of Christie Nguyen for an impeccable and successful thesis defense \u2018Altered transcription factor dynamics in PBAF-deficient melanoma\u2019!<\/p>

\"\"<\/strong><\/p>

\u00a0<\/p>

[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=\"1_2,1_2\" _builder_version=\"4.9.0\" custom_padding=\"|||30px|false|false\" border_color_all=\"#00AEEF\" border_width_left=\"2px\"][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_blurb title=\"March 2021\" use_icon=\"on\" font_icon=\"%%61%%\" icon_color=\"#00AEEF\" icon_placement=\"left\" content_max_width=\"100%\" use_icon_font_size=\"on\" icon_font_size=\"40px\" _builder_version=\"4.9.0\" header_level=\"h5\" header_font=\"Oswald|||on|||||\" header_text_color=\"#00AEEF\" header_line_height=\"1.4em\" body_font=\"Merriweather|700|||||||\" body_text_color=\"#000000\" body_font_size=\"20px\" body_line_height=\"1.8em\" custom_margin=\"|||-51px|false|false\" body_font_size_tablet=\"18px\" body_font_size_phone=\"16px\" body_font_size_last_edited=\"on|phone\" locked=\"off\"][\/et_pb_blurb][\/et_pb_column_inner][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_text _builder_version=\"4.9.0\" text_font=\"Arial|300|||||||\" text_font_size=\"18px\" text_line_height=\"1.8em\" width=\"150%\" max_width=\"150%\" custom_margin=\"|41px||-189px||\" custom_padding=\"|5px||0px||\" locked=\"off\"]<\/p>

Congratulations to Dr. Saul Carcamo on his outstanding thesis defense focused on SWI\/SNF subcomplex dynamics in malignant melanoma!<\/p>

\"\"<\/strong><\/p>

[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=\"1_2,1_2\" _builder_version=\"4.9.0\" custom_padding=\"|||30px|false|false\" border_color_all=\"#00AEEF\" border_width_left=\"2px\"][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_blurb title=\"February 2021\" use_icon=\"on\" font_icon=\"%%61%%\" icon_color=\"#00AEEF\" icon_placement=\"left\" content_max_width=\"100%\" use_icon_font_size=\"on\" icon_font_size=\"40px\" _builder_version=\"4.9.0\" header_level=\"h5\" header_font=\"Oswald|||on|||||\" header_text_color=\"#00AEEF\" header_line_height=\"1.4em\" body_font=\"Merriweather|700|||||||\" body_text_color=\"#000000\" body_font_size=\"20px\" body_line_height=\"1.8em\" custom_margin=\"|||-51px|false|false\" body_font_size_tablet=\"18px\" body_font_size_phone=\"16px\" body_font_size_last_edited=\"on|phone\" locked=\"off\"][\/et_pb_blurb][\/et_pb_column_inner][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_text _builder_version=\"4.9.0\" text_font=\"Arial|300|||||||\" text_font_size=\"18px\" text_line_height=\"1.8em\" width=\"150%\" max_width=\"150%\" custom_margin=\"|41px||-189px||\" custom_padding=\"|4px||0px||\" locked=\"off\"]<\/p>

Congratulations to Drs. Fl\u00e1via Ghiraldini and Dan Filipescu on their comprehensive review of histone variants and their chaperones in the pathogenesis of solid cancers. Read the article published in Nature Reviews, Cancer here<\/a>.<\/p>

\"\"<\/strong><\/p>

[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=\"1_2,1_2\" _builder_version=\"4.9.0\" custom_padding=\"|||30px|false|false\" border_color_all=\"#00AEEF\" border_width_left=\"2px\"][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_blurb title=\"October 2019\" use_icon=\"on\" font_icon=\"%%61%%\" icon_color=\"#00AEEF\" icon_placement=\"left\" content_max_width=\"100%\" use_icon_font_size=\"on\" icon_font_size=\"40px\" _builder_version=\"4.9.0\" header_level=\"h5\" header_font=\"Oswald|||on|||||\" header_text_color=\"#00AEEF\" header_line_height=\"1.4em\" body_font=\"Merriweather|700|||||||\" body_text_color=\"#000000\" body_font_size=\"20px\" body_line_height=\"1.8em\" custom_margin=\"|||-51px|false|false\" body_font_size_tablet=\"18px\" body_font_size_phone=\"16px\" body_font_size_last_edited=\"on|phone\" locked=\"off\"][\/et_pb_blurb][\/et_pb_column_inner][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_text _builder_version=\"4.9.0\" text_font=\"Arial|300|||||||\" text_font_size=\"18px\" text_line_height=\"1.8em\" width=\"150%\" max_width=\"150%\" custom_margin=\"|41px||-189px||\" custom_padding=\"|0px||0px||\" locked=\"off\"]<\/p>

Congratulations to Zulehka Qadeer and members of the Bernstein lab for their finding that that neuroblastoma in older children and adolescents harboring large deletions within the ATRX gene may be responsive to EZH2 inhibitor targeted therapy.\u00a0The team found that EZH2 and REST cooperate to block genes responsible for neuron development, and EZH2 inhibition induces killing of ATRX altered neuroblastoma cells. Read the article published in Cancer Cell here<\/a>.<\/p>

\"\"<\/strong><\/p>

[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=\"1_2,1_2\" _builder_version=\"4.9.0\" custom_padding=\"|||30px|false|false\" border_color_all=\"#00AEEF\" border_width_left=\"2px\"][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_blurb title=\"October 2018\" use_icon=\"on\" font_icon=\"%%61%%\" icon_color=\"#00AEEF\" icon_placement=\"left\" content_max_width=\"100%\" use_icon_font_size=\"on\" icon_font_size=\"40px\" _builder_version=\"4.9.0\" header_level=\"h5\" header_font=\"Oswald|||on|||||\" header_text_color=\"#00AEEF\" header_line_height=\"1.4em\" body_font=\"Merriweather|700|||||||\" body_text_color=\"#000000\" body_font_size=\"20px\" body_line_height=\"1.8em\" custom_margin=\"|||-51px|false|false\" body_font_size_tablet=\"18px\" body_font_size_phone=\"16px\" body_font_size_last_edited=\"on|phone\" locked=\"off\"][\/et_pb_blurb][\/et_pb_column_inner][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_text _builder_version=\"4.9.0\" text_font=\"Arial|300|||||||\" text_font_size=\"18px\" text_line_height=\"1.8em\" width=\"150%\" max_width=\"150%\" custom_margin=\"|41px||-189px||\" custom_padding=\"|3px||0px||\" locked=\"off\"]<\/p>

Congrats to Zhen Sun, Dan Filipescu and colleagues for identifying the mechanism underlying de novo macroH2A histone variant deposition! This study showed\u00a0that histone variant macroH2A is deposited across the mouse genome and subsequently pruned from transcriptionally active regions to establish macroH2A chromatin domains. Read the article published in Nature Structural & Molecular Biology here<\/a>.<\/p>

\"\"<\/strong><\/p>

[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=\"1_2,1_2\" _builder_version=\"4.9.0\" custom_padding=\"|||30px|false|false\" border_color_all=\"#00AEEF\" border_width_left=\"2px\"][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_blurb title=\"September 2018\" use_icon=\"on\" font_icon=\"%%61%%\" icon_color=\"#00AEEF\" icon_placement=\"left\" content_max_width=\"100%\" use_icon_font_size=\"on\" icon_font_size=\"40px\" _builder_version=\"4.9.0\" header_level=\"h5\" header_font=\"Oswald|||on|||||\" header_text_color=\"#00AEEF\" header_line_height=\"1.4em\" body_font=\"Merriweather|700|||||||\" body_text_color=\"#000000\" body_font_size=\"20px\" body_line_height=\"1.8em\" custom_margin=\"|||-51px|false|false\" body_font_size_tablet=\"18px\" body_font_size_phone=\"16px\" body_font_size_last_edited=\"on|phone\" locked=\"off\"][\/et_pb_blurb][\/et_pb_column_inner][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_text _builder_version=\"4.9.0\" text_font=\"Arial|300|||||||\" text_font_size=\"18px\" text_line_height=\"1.8em\" width=\"150%\" max_width=\"150%\" custom_margin=\"|41px||-189px||\" custom_padding=\"|2px||0px||\" locked=\"off\"]<\/p>

Congratulations to Dr. Zhen Sun on his outstanding thesis defense!<\/p>

\"\"<\/strong><\/p>

[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=\"1_2,1_2\" _builder_version=\"4.9.0\" custom_padding=\"|||30px|false|false\" border_color_all=\"#00AEEF\" border_width_left=\"2px\"][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_blurb title=\"August 2018\" use_icon=\"on\" font_icon=\"%%61%%\" icon_color=\"#00AEEF\" icon_placement=\"left\" content_max_width=\"100%\" use_icon_font_size=\"on\" icon_font_size=\"40px\" _builder_version=\"4.9.0\" header_level=\"h5\" header_font=\"Oswald|||on|||||\" header_text_color=\"#00AEEF\" header_line_height=\"1.4em\" body_font=\"Merriweather|700|||||||\" body_text_color=\"#000000\" body_font_size=\"20px\" body_line_height=\"1.8em\" custom_margin=\"|||-51px|false|false\" body_font_size_tablet=\"18px\" body_font_size_phone=\"16px\" body_font_size_last_edited=\"on|phone\" locked=\"off\"][\/et_pb_blurb][\/et_pb_column_inner][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_text _builder_version=\"4.9.0\" text_font=\"Arial|300|||||||\" text_font_size=\"18px\" text_line_height=\"1.8em\" width=\"150%\" max_width=\"150%\" custom_margin=\"|41px||-189px||\" custom_padding=\"|3px||0px||\" locked=\"off\"]<\/p>

Congratulations to Thomas Strub and members of the Bernstein lab for their discovery of the HDAC SIRT6 in BRAF-mutant melanoma as a novel epigenetic regulator of resistance to BRAF and MEK inhibitors. This work also identified IGFBP2 as a potential biomarker for MAPKi resistance. Read the article published in Nature Communications here<\/a>.<\/p>

\"\"<\/strong><\/p>

[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=\"1_2,1_2\" _builder_version=\"4.9.0\" custom_padding=\"|||30px|false|false\" border_color_all=\"#00AEEF\" border_width_left=\"2px\"][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_blurb title=\"November 2017\" use_icon=\"on\" font_icon=\"%%61%%\" icon_color=\"#00AEEF\" icon_placement=\"left\" content_max_width=\"100%\" use_icon_font_size=\"on\" icon_font_size=\"40px\" _builder_version=\"4.9.0\" header_level=\"h5\" header_font=\"Oswald|||on|||||\" header_text_color=\"#00AEEF\" header_line_height=\"1.4em\" body_font=\"Merriweather|700|||||||\" body_text_color=\"#000000\" body_font_size=\"20px\" body_line_height=\"1.8em\" custom_margin=\"|||-51px|false|false\" body_font_size_tablet=\"18px\" body_font_size_phone=\"16px\" body_font_size_last_edited=\"on|phone\" locked=\"off\"][\/et_pb_blurb][\/et_pb_column_inner][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_text _builder_version=\"4.9.0\" text_font=\"Arial|300|||||||\" text_font_size=\"18px\" text_line_height=\"1.8em\" width=\"150%\" max_width=\"150%\" custom_margin=\"|41px||-189px||\" custom_padding=\"|5px||0px||\" locked=\"off\"]<\/p>

Congratulations to Dan Hasson and the Bernstein & Hernando teams for their discovery of AMIGO2 as a survival gene and potential therapeutic target for metastatic melanoma. Read the article published in Molecular Cell here<\/a>. This work was published Nov. 16, 2017 and made the cover!<\/p>

\"\"<\/p>

An artistic representation of a genomic Self-Organizing Map, which displays the enrichment patterns of histone H3 acetylated at lysine 27 (H3K27ac) marking active regulatory regions in metastatic melanoma. In this issue of Molecular Cell, Fontanals-Cirera and Hasson et al. (pp. 731\u2013744) mapped the melanoma enhancer landscape and identified AMIGO2 and its interactor PTK7 as a therapeutically targetable axis to inhibit melanoma cell survival. They further demonstrate that AMIGO2 is regulated by \u201csuper-enhancers\u201d acquired during melanoma pathogenesis. Mosaic work by Dan Hasson. Photographed by Maru Teppei.<\/p>

[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=\"1_2,1_2\" _builder_version=\"4.9.0\" custom_padding=\"|||30px|false|false\" border_color_all=\"#00AEEF\" border_width_left=\"2px\"][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_blurb title=\"June 2017\" use_icon=\"on\" font_icon=\"%%61%%\" icon_color=\"#00AEEF\" icon_placement=\"left\" content_max_width=\"100%\" use_icon_font_size=\"on\" icon_font_size=\"40px\" _builder_version=\"4.9.0\" header_level=\"h5\" header_font=\"Oswald|||on|||||\" header_text_color=\"#00AEEF\" header_line_height=\"1.4em\" body_font=\"Merriweather|700|||||||\" body_text_color=\"#000000\" body_font_size=\"20px\" body_line_height=\"1.8em\" custom_margin=\"|||-51px|false|false\" body_font_size_tablet=\"18px\" body_font_size_phone=\"16px\" body_font_size_last_edited=\"on|phone\" locked=\"off\"][\/et_pb_blurb][\/et_pb_column_inner][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_text _builder_version=\"4.9.0\" text_font=\"Arial|300|||||||\" text_font_size=\"18px\" text_line_height=\"1.8em\" width=\"150%\" max_width=\"150%\" custom_margin=\"|41px||-189px||\" custom_padding=\"|3px||0px||\" locked=\"off\"]<\/p>

Congratulations to Dr. Zulekha Qadeer on her outstanding thesis defense!<\/p>

\"\"<\/strong><\/p>

[\/et_pb_text][\/et_pb_column_inner][\/et_pb_row_inner][et_pb_row_inner column_structure=\"1_2,1_2\" _builder_version=\"4.9.0\" custom_padding=\"|||30px|false|false\" border_color_all=\"#00AEEF\" border_width_left=\"2px\"][et_pb_column_inner type=\"1_2\" saved_specialty_column_type=\"2_3\" _builder_version=\"4.0.6\"][et_pb_blurb title=\"March 2017\" use_icon=\"on\" font_icon=\"%%61%%\" icon_color=\"#00AEEF\" icon_placement=\"left\" content_max_width=\"100%\" use_icon_font_size=\"on\" icon_font_size=\"40px\" _builder_version=\"4.9.0\" header_level=\"h5\" header_font=\"Oswald|||on|||||\" header_text_color=\"#00AEEF\" header_line_height=\"1.4em\" body_font=\"Merriweather|700|||||||\" body_text_color=\"#000000\" body_font_size=\"20px\" body_line_height=\"1.8em\" custom_margin=\"|||-51px|false|false\" body_font_size_tablet=\"18px\" body_font_size_phone=\"16px\" body_font_size_last_edited=\"on|phone\" locked=\"off\"][\/et_pb_blurb][\/et_pb_column_inner][et_pb_column_inner type=\"1_2\" saved_specialty_co","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-5226","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-json\/wp\/v2\/pages\/5226","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-json\/wp\/v2\/users\/393"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-json\/wp\/v2\/comments?post=5226"}],"version-history":[{"count":173,"href":"https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-json\/wp\/v2\/pages\/5226\/revisions"}],"predecessor-version":[{"id":6180,"href":"https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-json\/wp\/v2\/pages\/5226\/revisions\/6180"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-json\/wp\/v2\/media?parent=5226"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}