{"id":3010,"date":"2022-12-21T12:17:26","date_gmt":"2022-12-21T17:17:26","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/design\/?page_id=3010"},"modified":"2025-07-29T14:31:44","modified_gmt":"2025-07-29T18:31:44","slug":"research","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Fullwidth Header – Background Title Description – no slider – Section 1″ module_class=”header-title-desciption-no-slider-section1″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”rgba(0,174,239,0.09)” background_enable_color=”off” background_image=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab2\/wp-content\/uploads\/sites\/498\/2023\/12\/Emily_Bernstein_015-scaled.jpg” parallax=”on” custom_margin=”||-3px|||” custom_padding=”||||false|false” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”11vw” bottom_divider_arrangement=”above_content” animation_style=”fade” animation_duration=”750ms” saved_tabs=”all” locked=”off” collapsed=”on”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” custom_padding=”||272px|||” border_color_all=”RGBA(0,0,0,0)”][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”10%||8vw||false|false” custom_padding_tablet=”0vw||0vw||true|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet”][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Section 27 – Two Column – Title Over Text Over Button Next to Image” module_class=”section27_two_column_title_over_txt_over_btn_next_to_img” _builder_version=”4.9.0″ _module_preset=”default” background_enable_image=”off” parallax=”on” parallax_method=”off” custom_padding=”||16px|||” locked=”off” collapsed=”off”][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”118px|||||” animation_style=”fade” animation_duration=”700ms”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default”]<\/p>\n

Histone variant biology in development & disease<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.0″ _module_preset=”default” background_enable_image=”off” custom_padding=”0px|||||”][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” custom_margin=”|118px||||” custom_padding=”|42px||||”]<\/p>\n

We have uncovered a critical tumor suppressive role for the histone variant macroH2A in the progression of malignant melanoma using both\u00a0in vitro<\/em> and\u00a0in vivo<\/em> cellular models (Kapoor et al.,\u00a0Nature<\/em> 2010), and recently demonstrated a key role for macroH2A in regulating inflammation in the melanoma tumor microenvironment (Filipescu et al.,\u00a0Nature Cell Biol\u00a0<\/em>2023). We also reported that macroH2A acts as a barrier to induced pluripotency by repressing a set of genes required for the early stages of reprogramming (Gaspar-Maia et al.,\u00a0Nature Comms<\/em> 2013). Collectively, these studies suggest that macroH2A deficiency contributes to epigenetic plasticity and its loss facilitates oncogenic transcriptional programs. We continue to study macroH2A function using various mouse models and its role in the tumor microenvironment.<\/p>\n

Also, in the context of melanoma, we demonstrated an oncogenic role for the H2A.Z isoform, H2A.Z.2, in promoting melanoma cell proliferation (Vardabasso et al., Mol Cell\u00a0<\/em> 2015) and continue to study H2A.Z histone chaperone complexes in disease. We also investigate the role of histone variants in the context of the cancer epigenome, and how they control transcriptional output via 3D chromatin structure.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab2\/wp-content\/uploads\/sites\/498\/2023\/12\/Micro-C-chr11-1.jpg” title_text=”Micro-C chr11″ _builder_version=”4.9.0″ _module_preset=”default” width=”170%” custom_margin=”|||-208px||” custom_padding=”|||96px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_slider _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”4px||17px|||”][et_pb_slide heading=”Key Articles ” _builder_version=”4.9.0″ _module_preset=”default” header_text_align=”left” header_text_color=”#141414″ header_font_size=”31px” background_color=”#D6D6D6″ background_enable_color=”on” background_layout=”light” width=”94%” max_width=”101%” custom_padding=”0px|0px|0px|0px|true|true” sticky_transition=”on”]<\/p>\n

The histone variant macroH2A supresses melanoma progression through regulation of CDK8.<\/span>
<\/a><\/h1>\n

Kapoor A, Goldberg MS, Cumberland LK, Ratnakumar K, Segura MF, Emanuel PO, Menendez S, Vardabasso C, Leroy G, Vidal CI, Polsky D, Osman I, Garcia BA, Hernando E, Bernstein E.\u00a0Nature<\/em>\u00a02010, 468(7327): 1105-09<\/span><\/p>\n

[\/et_pb_slide][et_pb_slide heading=”Key Articles ” _builder_version=”4.9.0″ _module_preset=”default” header_text_align=”left” header_text_color=”#141414″ header_font_size=”31px” background_color=”#D6D6D6″ background_enable_color=”on” background_layout=”light” width=”94%” max_width=”101%” custom_padding=”0px|0px|0px|0px|true|true” sticky_transition=”on”]<\/p>\n

MacroH2A restricts inflammatory gene expression in melanoma cancer-associated fibroblasts by coordinating chromatin looping.<\/a><\/span><\/h1>\n

Filipescu D, Carcamo S, Agarwal A, Tung, Humblin E, Goldberg MS, Vyas NS, Beaumont KG, Demircioglu D, Sridhar S, Ghiraldini FG, Capparelli C, Aplin AE, Salmon H, Sebra R, Kamphorst AO, Merad M, Hasson D, Bernstein E.\u00a0Nat Cell Biol\u00a0<\/em> 2023, 25(9): 1332-1345<\/span><\/p>\n

 <\/p>\n

[\/et_pb_slide][et_pb_slide heading=”Key Articles ” _builder_version=”4.9.0″ _module_preset=”default” header_text_align=”left” header_text_color=”#141414″ header_font_size=”31px” background_color=”#D6D6D6″ background_enable_color=”on” background_layout=”light” width=”94%” max_width=”101%” custom_padding=”0px|||0px|false|false” sticky_transition=”on”]<\/p>\n

MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency.<\/a><\/span><\/h1>\n

Gaspar-Maia A, Qadeer ZA, Hasson D, Ratnakumar K, Leu NA, Leroy G, Liu S, Constanzi C, Valle-Garcia D, Schaniel C, Lemischka I, Garcia B, Pehrson JR, Bernstein E.\u00a0Nat Commun\u00a0<\/em> 2013, 4: 1565<\/span><\/p>\n

[\/et_pb_slide][et_pb_slide heading=”Key Articles ” _builder_version=”4.9.0″ _module_preset=”default” header_text_align=”left” header_text_color=”#141414″ header_font_size=”31px” background_color=”#D6D6D6″ background_enable_color=”on” background_layout=”light” width=”94%” max_width=”101%” custom_padding=”0px|||0px|false|false” sticky_transition=”on”]<\/p>\n

Histone variant H2A.Z.2 mediates proliferation and drug sensitivity of malignant melanoma.\u00a0<\/a><\/span><\/h1>\n

Vardabasso C, Gaspar-Maia A, Hasson D, P\u00fcnzeler S,\u00a0Valle-Garcia D, Straub T, Keilhauer EC, Strub T, Dong J, Panda T, Chung CY, Yao JL, Singh R, Segura MF, Fontanals-Cirera B, Verma A, Mann M, Hernando E, Hake SB, Bernstein E.\u00a0Mol Cell\u00a0<\/em> 2015, 59(1): 75-88.<\/span><\/p>\n

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[\/et_pb_slide][\/et_pb_slider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_row _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default”]<\/p>\n

Chromatin remodeling alterations in cancer<\/strong><\/h1>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.9.0″ _module_preset=”default” background_enable_image=”off” custom_padding=”0px||0px|||”][et_pb_row column_structure=”2_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”2_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”|129px||||”]<\/p>\n

The PBAF complex is a chromatin remodeling complex of the SWI\/SNF family, which is frequently mutated in cancer. ARID2, a key subunit of the PBAF complex, is the most mutated SWI\/SNF subunit in melanoma. We recently demonstrated that ARID2 loss-of-function results in defective PBAF complex assembly with a concomitant genomic redistribution of its sister BAF complex, promoting an invasive gene expression signature (Carcamo, Nguyen et al., Cell Reports 2022).\u00a0We aim to better <\/span>understand the mechanisms by which mutations in ARID2 and other PBAF subunits contribute to melanoma progression and metastasis via epigenetic and transcriptional reprogramming.<\/p>\n

We are also investigating the role of ATRX mutations in the context of pediatric cancer. ATRX is a SWI\/SNF-like chromatin remodeler first discovered in patients with inherited ATRX syndrome and is involved in numerous DNA-mediated processes including heterochromatin regulation, DNA repair, and transcriptional regulation. <\/span>In neuroblastoma, ATRX alterations often present as large, N-terminal deletions of varying length that produce in-frame fusion (IFF) proteins lacking key chromatin binding and protein interaction domains, leaving the C-terminal helicase domain intact. We previously discovered a sensitivity of ATRX IFF cells to EZH2 inhibitors (Qadeer et al., Cancer Cell 2019) and continue to <\/span>study transcriptional programs and epigenetic vulnerabilities in this indolent neuroblastoma subtype.\u00a0<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab2\/wp-content\/uploads\/sites\/498\/2023\/12\/Melanocytes-hi-res-new-1024×1024.jpg” title_text=”Melanocytes hi-res new” _builder_version=”4.9.0″ _module_preset=”default” width=”127%” custom_margin=”|||-60px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_slider _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”4px||17px|||” hover_enabled=”0″ sticky_enabled=”0″][et_pb_slide heading=”Key Articles ” _builder_version=”4.9.0″ _module_preset=”default” header_text_align=”left” header_text_color=”#141414″ header_font_size=”31px” background_color=”#D6D6D6″ background_enable_color=”on” background_layout=”light” width=”94%” max_width=”101%” custom_padding=”0px|0px|0px|0px|true|true” hover_enabled=”0″ sticky_transition=”on” sticky_enabled=”0″]<\/p>\n

The SWI\/SNF PBAF complex facilitates REST occupancy at repressive chromatin.\u00a0<\/a><\/span><\/h1>\n

Grossi E, Nguyen CB, Carcamo S, Calla\u00fa VK, Moran S, Filipescu D, Tagore S, Firestone TM, Keogh MC, Sun L, Izar B, Hasson D, Bernstein E. Molecular Cell <\/em>2025, 85(9): 1714-1729.e7<\/p>\n

 <\/p>\n

[\/et_pb_slide][et_pb_slide heading=”Key Articles ” _builder_version=”4.9.0″ _module_preset=”default” header_text_align=”left” header_text_color=”#141414″ header_font_size=”31px” background_color=”#D6D6D6″ background_enable_color=”on” background_layout=”light” width=”94%” max_width=”101%” custom_padding=”0px|0px|0px|0px|true|true” sticky_transition=”on”]<\/p>\n

Altered\u00a0BAF occupancy and transcription factor dynamics in PBAF-deficient melanoma.<\/a><\/span><\/h1>\n

Carcamo S, Nguyen CB, Grossi E, Filipescu D, Alpsoy A, Dhiman A, Sun D, Narang S, Imig J, Martin TC, Parsons R, Aifantis I, Tsirigos A, Aguirre-Ghiso JA, Dykhuizen EC, Hasson D,\u00a0Bernstein E.\u00a0Cell Rep<\/em>\u00a02022, 39(1): 1106337<\/p>\n

[\/et_pb_slide][et_pb_slide heading=”Key Articles ” _builder_version=”4.9.0″ _module_preset=”default” header_text_align=”left” header_text_color=”#141414″ header_font_size=”31px” background_color=”#D6D6D6″ background_enable_color=”on” background_layout=”light” width=”94%” max_width=”101%” custom_padding=”0px|0px|0px|0px|true|true” sticky_transition=”on”]<\/p>\n

ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures.\u00a0<\/a><\/span><\/h1>\n

Qadeer ZA, Valle-Garcia D, Hasson D, Sun Z, Cook A, Nguyen C, Soriano A, Ma A, Griffiths LM, Zeineldin M, Filipescu D, Jubierre L, Chowdhury A, Deevy O, Chen X, Finkelstein DB, Bahrami A, Stewart E, Federico S, Gallego S, Dekio F, Fowkes M, Meni D, Maris JM, Weiss WA, Roberts SS, Cheung NV, Jin J, Segura MF, Dyer MA, Bernstein E.\u00a0Cancer Cell\u00a0<\/em>2019, 36(5): 512-527<\/p>\n

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[\/et_pb_slide][\/et_pb_slider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_divider color=”#141414″ _builder_version=”4.9.0″ _module_preset=”default”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Fullwidth Text Over White Background – Section” module_class=”section_fulllwidth_text_simple” _builder_version=”4.9.0″ custom_padding=”0px||0px|||” animation_style=”fade” animation_duration=”750ms” locked=”off” collapsed=”on”][et_pb_row admin_label=”row” _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_font=”|700|||||||” text_font_size=”37px” header_text_color=”#00a6e5″ custom_margin=”17px|||||”]<\/p>\n

FUNDING\u00a0<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”92px||22px|||”][et_pb_column type=”1_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab2\/wp-content\/uploads\/sites\/498\/2023\/10\/NIH.png” title_text=”NIH” _builder_version=”4.9.0″ _module_preset=”default” width=”94.9%” custom_padding=”|0px||||”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab2\/wp-content\/uploads\/sites\/498\/2023\/10\/CDMRP.png” title_text=”CDMRP” _builder_version=”4.9.0″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab2\/wp-content\/uploads\/sites\/498\/2023\/10\/MRA.png” title_text=”MRA” _builder_version=”4.9.0″ _module_preset=”default”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab2\/wp-content\/uploads\/sites\/498\/2023\/10\/BSF.png” title_text=”BSF” _builder_version=”4.9.0″ _module_preset=”default” custom_margin=”|||15px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.9.0″ _module_preset=”default” custom_margin=”|auto||241px||” custom_padding=”0px|||||”][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab2\/wp-content\/uploads\/sites\/498\/2023\/10\/SKC.jpg” title_text=”SKC” _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”0px||0px|||”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab2\/wp-content\/uploads\/sites\/498\/2023\/10\/MRF.png” title_text=”MRF” _builder_version=”4.9.0″ _module_preset=”default” custom_margin=”22px|||||” custom_padding=”||8px|||”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab2\/wp-content\/uploads\/sites\/498\/2023\/10\/NCI-CC-Logo.jpg” title_text=”NCI CC Logo” _builder_version=”4.9.0″ _module_preset=”default” custom_margin=”43px|||-71px||” custom_padding=”|209px||3px||”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”65px|||||”][et_pb_column type=”4_4″ _builder_version=”4.9.0″ _module_preset=”default”][et_pb_divider color=”#141414″ _builder_version=”4.9.0″ _module_preset=”default”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Footer Fullwidth – Section 13″ module_class=”footer-section” _builder_version=”4.9.0″ background_color=”#FFFFFF” use_background_color_gradient=”on” background_color_gradient_start=”#ffffff” background_color_gradient_end=”#ffffff” background_image=”https:\/\/labs.icahn.mssm.edu\/bernsteinlab2\/wp-content\/uploads\/sites\/498\/2022\/10\/Rectangle-3.png” background_enable_image=”off” max_width=”100%” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|phone” module_alignment=”center” custom_margin=”100px|||176px|false|false” custom_padding=”3px|0px|0px|0px|false|false” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”14%” animation_starting_opacity=”100%” saved_tabs=”all” locked=”off” collapsed=”on”][et_pb_row _builder_version=”4.9.0″ background_color=”#FFFFFF” background_color_gradient_direction=”38deg” module_alignment=”center” custom_margin=”|auto||147px||” locked=”off” collapsed=”on”][et_pb_column type=”4_4″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_social_media_follow icon_color=”#00AEEF” _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” text_orientation=”center” custom_margin=”||17px|||”][et_pb_social_media_follow_network social_network=”twitter” url=”https:\/\/twitter.com\/bernstein_lab” use_icon_font_size=”on” icon_font_size=”24px” _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” background_enable_color=”on”]twitter[\/et_pb_social_media_follow_network][\/et_pb_social_media_follow][et_pb_text _builder_version=”4.9.0″ _module_preset=”default” text_text_color=”#FFFFFF” text_font_size=”24px”]<\/p>\n

Contact Us<\/strong><\/span><\/p>\n

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Resources<\/strong><\/a><\/span><\/p>\n

Department of Oncological Sciences<\/span><\/a>
Black Family Stem Cell Institute<\/span><\/a>
Tisch Cancer Institute<\/span><\/a>
Department of Dermatology<\/a>
Graduate School of Biomedical Sciences<\/span><\/a><\/p>\n

\"MSSMLogo\"<\/a><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.25em” header_font=”||||||||” header_4_font=”|700||on|||||” header_4_font_size=”16px” header_4_letter_spacing=”1px” header_4_line_height=”1.5em” background_color=”#FFFFFF” background_layout=”dark” locked=”off”]<\/p>\n

E-mail
<\/strong>emily.bernstein@mssm.edu<\/a><\/span><\/p>\n

Phone
<\/strong>Tel: 212-824-9335<\/p>\n

<\/span><\/p>\n

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Lab Address <\/strong><\/span>
Department of Oncological Sciences<\/span>
Icahn School of Medicine at Mount Sinai<\/span>
One Gustave L. Levy Place, Box 1044A<\/span>
New York, NY 10029<\/span><\/p>\n

Administrative Assistant<\/strong><\/span>
Genevieve Joseph, PhD<\/span>
Tel: 212-824-9367<\/span>
E-mail:<\/span> genevieve.joseph@mssm.edu<\/a><\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Histone variant biology in development & diseaseWe have uncovered a critical tumor suppressive role for the histone variant macroH2A in the progression of malignant melanoma using both\u00a0in vitro and\u00a0in vivo cellular models (Kapoor et al.,\u00a0Nature 2010), and recently demonstrated a key role for macroH2A in regulating inflammation in the melanoma tumor microenvironment (Filipescu et al.,\u00a0Nature […]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-3010","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-json\/wp\/v2\/pages\/3010","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-json\/wp\/v2\/users\/545"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-json\/wp\/v2\/comments?post=3010"}],"version-history":[{"count":81,"href":"https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-json\/wp\/v2\/pages\/3010\/revisions"}],"predecessor-version":[{"id":6348,"href":"https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-json\/wp\/v2\/pages\/3010\/revisions\/6348"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/bernsteinlab\/wp-json\/wp\/v2\/media?parent=3010"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}