Dan Filipescu, PhD Instructor
Histone variants are incorporated and exchanged at specific regions of the genome to regulate cellular identity and homeostasis and as such, frequently deregulated in human tumors. To understand their function and the consequences of their alterations, as well as their implications for cancer diagnosis and treatment, Dan is examining histone variant dynamics in vivo, making use of genetically engineered mouse models of cancer.
Funding Sources: Research Grant for Skin Cancer and Melanoma, American Skin Association, Dan Filipescu (PI)
Dan Hasson, PhD Associate Professor
Dan’s main research interest is focused on understanding the functional role of cis DNA regulatory elements in cancer initiation, progression, metastasis, and dormancy. Dan also studies the role of chromatin remodelers and transcription factors (TFs) that control the functional output of these elements, as well as the 3D chromatin structure associated with their regulation. Dan utilizes innovative genomic approaches and computational tools to support our laboratory’s studies investigating the role of epigenetics in cancers such as melanoma and neuroblastoma. Dan is also Co-Director of the Bioinformatics for Next Generation Sequencing (BiNGS) core of the Tisch Cancer Institute.