Beck Laboratory

Publications

Detection and implications of cortical demyelination in MS 

  1. Beck ES, Gai N, Filippini S, Maranzano J, Nair G, Reich DS. Inversion Recovery Susceptibility Weighted Imaging With Enhanced T2 Weighting at 3 T Improves Visualization of Subpial Cortical Multiple Sclerosis Lesions. Invest Radiol. 2020 Nov;55(11):727-735. doi: 10.1097/RLI.0000000000000698. PubMed PMID: 32604385; PubMed Central PMCID: PMC7541598. 
  2. Beck ES, Maranzano J, Luciano NJ, Parvathaneni P, Filippini S, Morrison M, Suto DJ, Wu T, van Gelderen P, de Zwart JA, Antel S, Fetco D, Ohayon J, Andrada F, Mina Y, Thomas C, Jacobson S, Duyn J, Cortese I, Narayanan S, Nair G, Sati P, Reich DS. Cortical lesion hotspots and association of subpial lesions with disability in multiple sclerosis. Mult Scler. 2022 Aug;28(9):1351-1363. doi: 10.1177/13524585211069167. Epub 2022 Feb 10. PubMed PMID: 35142571; PubMed Central PMCID: PMC9256754. 
  3. Beck ES, Sati P, Sethi V, Kober T, Dewey B, Bhargava P, Nair G, Cortese IC, Reich DS. Improved Visualization of Cortical Lesions in Multiple Sclerosis Using 7T MP2RAGE. AJNR Am J Neuroradiol. 2018 Mar;39(3):459-466. doi: 10.3174/ajnr.A5534. Epub 2018 Feb 8. PubMed PMID: 29439120; PubMed Central PMCID: PMC6082739. 
  4. Bouman PM, Noteboom S, Nobrega Santos FA, Beck ES, Bliault G, Castellaro M, Calabrese M, Chard DT, Eichinger P, Filippi M, Inglese M, Lapucci C, Marciniak A, Moraal B, Morales Pinzon A, Mühlau M, Preziosa P, Reich DS, Rocca MA, Schoonheim MM, Twisk JWR, Wiestler B, Jonkman LE, Guttmann CRG, Geurts JJG, Steenwijk MD. Multicenter Evaluation of AI-generated DIR and PSIR for Cortical and Juxtacortical Multiple Sclerosis Lesion Detection. Radiology. 2023 Apr;307(2):e221425. doi: 10.1148/radiol.221425. Epub 2023 Feb 7. PubMed PMID: 36749211; PubMed Central PMCID: PMC10102645. 
  5. La Rosa F, Beck ES, Maranzano J, Todea RA, van Gelderen P, de Zwart JA, Luciano NJ, Duyn JH, Thiran JP, Granziera C, Reich DS, Sati P, Bach Cuadra M. Multiple sclerosis cortical lesion detection with deep learning at ultra-high-field MRI. NMR Biomed. 2022 Aug;35(8):e4730. doi: 10.1002/nbm.4730. Epub 2022 Mar 31. PubMed PMID: 35297114; PubMed Central PMCID: PMC9539569. 
  6. La Rosa F, Wynen M, Al-Louzi O, Beck ES, Huelnhagen T, Maggi P, Thiran JP, Kober T, Shinohara RT, Sati P, Reich DS, Granziera C, Absinta M, Bach Cuadra M. Cortical lesions, central vein sign, and paramagnetic rim lesions in multiple sclerosis: Emerging machine learning techniques and future avenues. Neuroimage Clin. 2022;36:103205. doi: 10.1016/j.nicl.2022.103205. Epub 2022 Sep 24. Review. PubMed PMID: 36201950; PubMed Central PMCID: PMC9668629. 
  7. Liu J, Beck ES, Filippini S, van Gelderen P, de Zwart JA, Norato G, Sati P, Al-Louzi O, Kolb H, Donadieu M, Morrison M, Duyn JH, Reich DS. Navigator-Guided Motion and B0 Correction of T2*-Weighted Magnetic Resonance Imaging Improves Multiple Sclerosis Cortical Lesion Detection. Invest Radiol. 2021 Jul 1;56(7):409-416. doi: 10.1097/RLI.0000000000000754. PubMed PMID: 34086012; PubMed Central PMCID: PMC8269363. 
  8.  Manning AR, Beck ES, Schindler MK, Nair G, Clark KA, Parvathaneni P, Reich DS, Shinohara RT, Solomon AJ. T1 /T2 ratio from 3T MRI improves multiple sclerosis cortical lesion contrast. J Neuroimaging. 2023 May-Jun;33(3):434-445. doi: 10.1111/jon.13088. Epub 2023 Jan 30. PubMed PMID: 36715449. 

Additional MRI markers in MS 

  1. Okar SV, Hu F, Shinohara RT, Beck ES, Reich DS, Ineichen BV. The etiology and evolution of magnetic resonance imaging-visible perivascular spaces: Systematic review and meta-analysis. Front Neurosci. 2023;17:1038011. doi: 10.3389/fnins.2023.1038011. eCollection 2023. PubMed PMID: 37065926; PubMed Central PMCID: PMC10098201. 
  2. La Rosa F, Dos Santos Silva J, Dereskewicz E, et al. BrainAgeNeXt: Advancing Brain Age Modeling for Individuals with Multiple Sclerosis. Preprint. medRxiv. 2024;2024.08.10.24311686. Published 2024 Aug 11. doi:10.1101/2024.08.10.24311686
  3. Levy S, Sandry J, Beck ES, Brandstadter R, Katz Sand I, Sumowski JF. Pattern of thalamic nuclei atrophy in early relapse-onset multiple sclerosis. Mult Scler Relat Disord. 2022 Nov;67:104083. doi: 10.1016/j.msard.2022.104083. Epub 2022 Jul 29. PubMed PMID: 35940020. 
  4. Al-Louzi O, Manukyan S, Donadieu M, Absinta M, Letchuman V, Calabresi B, Desai P, Beck ES, Roy S, Ohayon J, Pham DL, Thomas A, Jacobson S, Cortese I, Auluck PK, Nair G, Sati P, Reich DS. Lesion size and shape in central vein sign assessment for multiple sclerosis diagnosis: An in vivo and postmortem MRI study. Mult Scler. 2022 Oct;28(12):1891-1902. doi: 10.1177/13524585221097560. Epub 2022 Jun 8. PubMed PMID: 35674284; PubMed Central PMCID: PMC9489648. 
  5. Kolb H, Al-Louzi O, Beck ES, Sati P, Absinta M, Reich DS. From pathology to MRI and back: Clinically relevant biomarkers of multiple sclerosis lesions. Neuroimage Clin. 2022;36:103194. doi: 10.1016/j.nicl.2022.103194. Epub 2022 Sep 14. Review. PubMed PMID: 36170753; PubMed Central PMCID: PMC9668624. 
  6. Al-Louzi O, Letchuman V, Manukyan S, Beck ES, Roy S, Ohayon J, Pham DL, Cortese I, Sati P, Reich DS. Central Vein Sign Profile of Newly Developing Lesions in Multiple Sclerosis: A 3-Year Longitudinal Study. Neurol Neuroimmunol Neuroinflamm. 2022 Mar;9(2). doi: 10.1212/NXI.0000000000001120. Print 2022 Mar. PubMed PMID: 35027474; PubMed Central PMCID: PMC8759076. 
  7. Kolb H, Absinta M, Beck ES, Ha SK, Song Y, Norato G, Cortese I, Sati P, Nair G, Reich DS. 7T MRI Differentiates Remyelinated from Demyelinated Multiple Sclerosis Lesions. Ann Neurol. 2021 Oct;90(4):612-626. doi: 10.1002/ana.26194. Epub 2021 Sep 2. PubMed PMID: 34390015; PubMed Central PMCID: PMC9291186. 

Development of novel MRI techniques for improved brain imaging 

  1. Jakob Assländer, Andrew Mao, Elisa Marchetto, Erin S. Beck, Francesco La Rosa, Robert W. Charlson, Timothy M. Shepherd, Sebastian Flassbeck; Unconstrained quantitative magnetization transfer imaging: Disentangling T1 of the free and semi-solid spin pools. Imaging Neuroscience 2024; 2 1–16. doi: https://doi.org/10.1162/imag_a_00177
  2. van Gelderen P, Li X, de Zwart JA, Beck ES, Okar SV, Huang Y, Lai K, Sulam J, van Zijl PCM, Reich DS, Duyn JH, Liu J. Effect of motion, cortical orientation and spatial resolution on quantitative imaging of cortical R2* and magnetic susceptibility at 0.3 mm in-plane resolution at 7 T. Neuroimage. 2023 Apr 15;270:119992. doi: 10.1016/j.neuroimage.2023.119992. Epub 2023 Feb 27. PubMed PMID: 36858332.