{"id":3010,"date":"2022-12-21T12:17:26","date_gmt":"2022-12-21T17:17:26","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/design\/?page_id=3010"},"modified":"2025-04-23T11:21:26","modified_gmt":"2025-04-23T15:21:26","slug":"research","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/bechhoferlab\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

[et_pb_section fb_built=”1″ admin_label=”Fullwidth Header – Background Title Description – no slider – Section 1″ module_class=”header-title-desciption-no-slider-section1″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”rgba(0,174,239,0.09)” background_enable_color=”off” background_image=”https:\/\/labs.icahn.mssm.edu\/bechhoferlab-new\/wp-content\/uploads\/sites\/566\/2022\/07\/ai-002-1.jpg” parallax=”on” custom_padding=”||||false|false” bottom_divider_style=”ramp2″ bottom_divider_color=”#FFFFFF” bottom_divider_height=”11vw” bottom_divider_arrangement=”above_content” saved_tabs=”all” locked=”on” collapsed=”on”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)” border_color_all=”RGBA(0,0,0,0)” collapsed=”on”][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default” custom_padding=”10%||8vw||false|false” custom_padding_tablet=”0vw||0vw||true|false” custom_padding_phone=”” custom_padding_last_edited=”on|tablet”][et_pb_text admin_label=”Text – Title” _builder_version=”4.9.0″ _module_preset=”b3e3ff14-5f5c-4608-8ecf-1885ce3da7aa” header_font=”||||||||” header_text_color=”#FFFFFF” header_font_size=”48px” header_line_height=”60px” custom_margin=”||10px||false|false” header_font_size_tablet=”40px” header_font_size_phone=”24px” header_font_size_last_edited=”on|desktop”]<\/p>\n

Research<\/strong><\/h1>\n

[\/et_pb_text][et_pb_text admin_label=”Text – Description” _builder_version=”4.9.0″ _module_preset=”da86b6f0-f83c-4c7c-bdd8-3019777ddffe” text_font=”||||||||” text_text_color=”#FFFFFF” text_font_size=”20px” text_line_height=”32px” text_font_size_tablet=”15px” text_font_size_phone=”14px” text_font_size_last_edited=”on|desktop” disabled_on=”on|on|on” disabled=”on”]<\/p>\n

Our current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.9.0″ _module_preset=”default” background_color=”RGBA(0,0,0,0)”][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Section 27 – Two Column – Title Over Text Over Button Next to Image” module_class=”section27_two_column_title_over_txt_over_btn_next_to_img” _builder_version=”4.9.0″ _module_preset=”default” background_image=”https:\/\/labs.icahn.mssm.edu\/bechhoferlab-new\/wp-content\/uploads\/sites\/566\/2022\/12\/9-alt.png” parallax=”on” parallax_method=”off” locked=”off” collapsed=”on”][et_pb_row column_structure=”1_2,1_2″ _builder_version=”4.9.0″ module_alignment=”center” custom_margin=”|||” custom_margin_tablet=”” custom_margin_phone=”” custom_margin_last_edited=”on|phone” custom_padding=”||150px|||” global_module=”3003″ collapsed=”on”][et_pb_column type=”1_2″ _builder_version=”3.25″ background_color_gradient_direction=”35deg” custom_padding=”|60px||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” header_font=”||||||||” header_text_align=”left” header_text_color=”#2b2b2b” header_font_size=”36px” header_line_height=”1.3em” header_2_font=”|700|||||||” header_2_text_align=”left” header_2_text_color=”#2b2b2b” header_2_font_size=”36px” header_2_line_height=”1.5em” text_orientation=”center” module_alignment=”center” custom_margin=”||10px|” disabled_on=”on|on|on” disabled=”on”]<\/p>\n

Cell Therapies for Improving Tissue Regeneration<\/strong><\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#141414″ text_line_height=”1.9em” header_font=”||||||||” header_2_font=”||||||||” module_alignment=”center” custom_margin=”||30px|” hover_enabled=”0″ sticky_enabled=”0″]<\/p>\n

Decay of bacterial mRNA is an essential function, needed constitutively to regenerate ribonucleotide pools and in a regulated fashion to confer flexibility on gene expression programs.\u00a0 Relative to our understanding of the processes of transcription and translation, much less is known about how mRNA turnover is accomplished, and much of what we do know comes from studies in\u00a0Escherichia coli<\/em>, the Gram-negative model organism.\u00a0 We have been studying mRNA decay and processing in the Gram-positive bacterium,\u00a0Bacillus subtilis<\/em>, which is so far the best understood organism other than\u00a0E. coli<\/em>\u00a0in terms of the ribonucleases involved in mRNA decay.\u00a0 Over the years, our lab has discovered many genes encoding ribonuclease activities, and has characterized the bacterial mRNA decay process, using a handful of \u201cmodel\u201d mRNAs as representatives of the transcriptome.\u00a0 We now routinely use NextGen sequencing technology to assay all expressed mRNAs at once, employing newly-constructed mutant strains to determine the role that particular activities play in mRNA turnover.\u00a0 In addition to studying individual proteins, we are beginning to investigate a protein complex called the \u201cdegradosome,\u201d which comprises several proteins that may function jointly in achieving efficient mRNA turnover.<\/p>\n

[\/et_pb_text][et_pb_button button_url=”https:\/\/labs.icahn.mssm.edu\/design\/option1-research” button_text=”Read More” _builder_version=”4.9.0″ _module_preset=”default” custom_button=”on” button_text_color=”#FFFFFF” button_bg_color=”#00AEEF” button_border_radius=”0px” box_shadow_style=”preset1″ locked=”off” disabled_on=”on|on|on” disabled=”on”][\/et_pb_button][\/et_pb_column][et_pb_column type=”1_2″ module_class=”imageallignment” _builder_version=”4.9.0″ background_color=”RGBA(0,0,0,0)” use_background_color_gradient=”on” background_color_gradient_start=”#00aeef” background_color_gradient_end=”#221f72″ background_color_gradient_direction=”115deg” custom_padding=”|||” custom_padding__hover=”|||” custom_css_main_element_last_edited=”on|desktop” custom_css_main_element_tablet=”margin-top:60px!important”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bechhoferlab-new\/wp-content\/uploads\/sites\/566\/2025\/04\/Research-Figure.jpg” title_text=”Research-Figure” align=”center” _builder_version=”4.9.0″ background_color=”#221F72″ custom_margin=”-40px|40px|40px|-40px|false|false” custom_margin_tablet=”” custom_margin_phone=”-40px|40px|40px|-40px|false|false” custom_margin_last_edited=”on|phone” custom_padding=”|||” animation_style=”zoom” animation_direction=”right” animation_intensity_zoom=”6%” animation_starting_opacity=”100%” hover_enabled=”0″ always_center_on_mobile=”off” sticky_enabled=”0″][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” collapsed=”on”][et_pb_column _builder_version=”4.9.0″ _module_preset=”default” type=”4_4″][et_pb_image _builder_version=”4.9.0″ _module_preset=”default” hover_enabled=”0″ sticky_enabled=”0″ title_text=”Bechhofer-Research” src=”https:\/\/labs.icahn.mssm.edu\/bechhoferlab-new\/wp-content\/uploads\/sites\/566\/2025\/04\/Bechhofer-Research.jpg”][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.9.0″ _module_preset=”default” collapsed=”on”][et_pb_column _builder_version=”4.9.0″ _module_preset=”default” type=”4_4″][et_pb_image _builder_version=”4.9.0″ _module_preset=”default” title_text=”Bechhofer-Research-7″ src=”https:\/\/labs.icahn.mssm.edu\/bechhoferlab-new\/wp-content\/uploads\/sites\/566\/2025\/04\/Bechhofer-Research-7.jpg” hover_enabled=”0″ sticky_enabled=”0″][\/et_pb_image][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.9.0″ module_alignment=”center” custom_margin=”|auto|150px|auto||” custom_padding=”0px||0px|” global_module=”3004″ collapsed=”on” disabled_on=”on|on|on” disabled=”on”][et_pb_column type=”1_2″ _builder_version=”4.9.0″ background_color=”#00AEEF” use_background_color_gradient=”on” background_color_gradient_start=”#00aeef” background_color_gradient_end=”#d80b8c” background_color_gradient_direction=”33deg” background_enable_image=”off” parallax=”on” custom_padding=”|5%||5%” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bechhoferlab-new\/wp-content\/uploads\/sites\/566\/2025\/04\/Bechhofer-Research.jpg” title_text=”Bechhofer-Research” align=”center” align_tablet=”center” align_phone=”” align_last_edited=”on|desktop” _builder_version=”4.9.0″ custom_margin=”-20px||-20px|” custom_padding=”|||” animation_style=”zoom” animation_direction=”left” animation_intensity_zoom=”10%” animation_starting_opacity=”100%” hover_enabled=”0″ sticky_enabled=”0″][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”3.25″ custom_padding=”40px|40px|40px|40px” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ header_font=”|700|||||||” header_font_size=”36px” header_3_font=”Playfair Display|700|||||||” header_3_text_color=”#2b2b2b” header_3_font_size=”28px” header_3_line_height=”1.5em” custom_margin=”||10px|” disabled_on=”on|on|on” disabled=”on”]<\/p>\n

Stem Cell Niche in Musculoskeletal Tissues<\/strong><\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#141414″ text_line_height=”1.9em” header_font=”||||||||” header_2_font=”||||||||” module_alignment=”center” custom_margin=”||30px|” disabled_on=”on|on|on” disabled=”on”]<\/p>\n

One of the causes contributing to poor healing of aged musculoskeletal tissues is that mature tissues have decreased stem cell numbers and activities. To overcome this hurdle, cell-based therapies have been proposed as a strategy to trigger native tissue formation and function restoration.<\/p>\n

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Tendon & Enthesis Mechanotransduction via Primary Cilia<\/strong><\/h2>\n

[\/et_pb_text][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#141414″ text_line_height=”1.9em” header_font=”||||||||” header_2_font=”||||||||” module_alignment=”center” custom_margin=”||30px|” disabled_on=”on|on|on” disabled=”on”]<\/p>\n

Tendons are mechanosensitive load-bearing tissues. Decreased loading causes defects during development and structural remodeling in adult tendons. \u00a0To further illustrate underlying principles, tendon progenitor\/stem cells have been reported to acquire chondrogenic and osteogenic features after mechanical stimulation.\u00a0<\/p>\n

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Contact Us<\/strong><\/p>\n

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Icahn School of Medicine
at Mount Sinai
One Gustave L. Levy Place
<\/span>Annenberg
<\/span>New York, NY 10029<\/span><\/p>\n

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Phone
<\/strong>Tel: 212-241-5628
Fx: 212-996-7214<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”3.25″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.9.0″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.25em” header_font=”||||||||” header_4_font=”|700||on|||||” header_4_font_size=”16px” header_4_letter_spacing=”1px” header_4_line_height=”1.5em” background_layout=”dark” locked=”off”]<\/p>\n

Lab Address <\/strong>
David Bechhofer, PhD
Annenberg Building
19th Floor, Room 19-98
1468 Madison Avenue
New York NY, 10029<\/p>\n

Mailing Address <\/strong><\/p>\n

Bechhofer Lab
Icahn School of Medicine at Mount Sinai
Department of Pharmacology and Systems Therapeutics
One Gustave L. Levy Place,
<\/span>Box 1603
<\/span>New York, NY 10029<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

ResearchOur current research focuses on birth of the hair follicle niche, growth control and regeneration, and tissue regression and reorganization.Cell Therapies for Improving Tissue RegenerationDecay of bacterial mRNA is an essential function, needed constitutively to regenerate ribonucleotide pools and in a regulated fashion to confer flexibility on gene expression programs.\u00a0 Relative to our understanding of […]<\/p>\n","protected":false},"author":545,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","inline_featured_image":false,"footnotes":""},"class_list":["post-3010","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/bechhoferlab\/wp-json\/wp\/v2\/pages\/3010","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/bechhoferlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/bechhoferlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/bechhoferlab\/wp-json\/wp\/v2\/users\/545"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/bechhoferlab\/wp-json\/wp\/v2\/comments?post=3010"}],"version-history":[{"count":4,"href":"https:\/\/labs.icahn.mssm.edu\/bechhoferlab\/wp-json\/wp\/v2\/pages\/3010\/revisions"}],"predecessor-version":[{"id":4520,"href":"https:\/\/labs.icahn.mssm.edu\/bechhoferlab\/wp-json\/wp\/v2\/pages\/3010\/revisions\/4520"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/bechhoferlab\/wp-json\/wp\/v2\/media?parent=3010"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}