{"id":8,"date":"2016-06-02T21:05:18","date_gmt":"2016-06-02T21:05:18","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/bchenlab\/?page_id=8"},"modified":"2021-08-06T12:52:16","modified_gmt":"2021-08-06T12:52:16","slug":"research-overview","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/bchenlab\/","title":{"rendered":"Overview"},"content":{"rendered":"<div id=\"attachment_32\" class=\"wp-caption alignright\" style=\"width: 300px\"><a href=\"https:\/\/labs.icahn.mssm.edu\/bchenlab\/wp-content\/uploads\/sites\/14\/2016\/06\/cropped-ButtonsR.jpg\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-32 size-medium\" src=\"https:\/\/labs.icahn.mssm.edu\/bchenlab\/wp-content\/uploads\/sites\/14\/2016\/06\/cropped-ButtonsR-300x300.jpg\" alt=\"cropped-ButtonsR.jpg\" width=\"300\" height=\"300\" srcset=\"https:\/\/labs.icahn.mssm.edu\/bchenlab\/wp-content\/uploads\/sites\/14\/2016\/06\/cropped-ButtonsR-300x300.jpg 300w, https:\/\/labs.icahn.mssm.edu\/bchenlab\/wp-content\/uploads\/sites\/14\/2016\/06\/cropped-ButtonsR-150x150.jpg 150w, https:\/\/labs.icahn.mssm.edu\/bchenlab\/wp-content\/uploads\/sites\/14\/2016\/06\/cropped-ButtonsR-270x270.jpg 270w, https:\/\/labs.icahn.mssm.edu\/bchenlab\/wp-content\/uploads\/sites\/14\/2016\/06\/cropped-ButtonsR-192x192.jpg 192w, https:\/\/labs.icahn.mssm.edu\/bchenlab\/wp-content\/uploads\/sites\/14\/2016\/06\/cropped-ButtonsR-180x180.jpg 180w, https:\/\/labs.icahn.mssm.edu\/bchenlab\/wp-content\/uploads\/sites\/14\/2016\/06\/cropped-ButtonsR-32x32.jpg 32w, https:\/\/labs.icahn.mssm.edu\/bchenlab\/wp-content\/uploads\/sites\/14\/2016\/06\/cropped-ButtonsR.jpg 512w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><p class=\"wp-caption-text\">HIV Virological synapse between an infected Jurkat T cell (green) and three primary CD4+ T cells (red).<\/p><\/div>\n<p>Our laboratory is interested in understanding virus host interactions that cause disease in humans.\u00a0 We focus on human immunodeficiency virus type 1 (HIV-1), which causes a chronic infection of the immune system, and for which there now effective treatments, but still no vaccine or cure.\u00a0 Much of our work has focused on how the virus exploits cell-cell interactions to facilitate its spread throughout the immune system. \u00a0We study adhesive contacts\u00a0that can form between infected and\u00a0uninfected cells called virological synapses. \u00a0We have conducted\u00a0live confocal imaging studies that have\u00a0documented how virus assembly is coordinated with the formation of virological synapses. We have also learned how infection through virological synapses can facilitate viral escape from neutralizing antibodies and also helps the virus to maintain a high level of genetic diversity. \u00a0Our current studies are focusing on mechanisms of immune escape by cell-cell transmission, examining whether some people may have antibodies that are associated with spontaneous control of HIV, and trying to understand how the virus initiates inflammation during untreated and treated infection. \u00a0A better understanding of the immune cell interactions and interactions of HIV infected cells with the immune system may help to develop new vaccine approaches or strategies to cure the infection.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Our laboratory is interested in understanding virus host interactions that cause disease in humans.\u00a0 We focus on human immunodeficiency virus type 1 (HIV-1), which causes a chronic infection of the immune system, and for which there now effective treatments, but still no vaccine or cure.\u00a0 Much of our work has focused on how the virus [&hellip;]<\/p>\n","protected":false},"author":77,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-8","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/bchenlab\/wp-json\/wp\/v2\/pages\/8","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/bchenlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/bchenlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/bchenlab\/wp-json\/wp\/v2\/users\/77"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/bchenlab\/wp-json\/wp\/v2\/comments?post=8"}],"version-history":[{"count":14,"href":"https:\/\/labs.icahn.mssm.edu\/bchenlab\/wp-json\/wp\/v2\/pages\/8\/revisions"}],"predecessor-version":[{"id":147,"href":"https:\/\/labs.icahn.mssm.edu\/bchenlab\/wp-json\/wp\/v2\/pages\/8\/revisions\/147"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/bchenlab\/wp-json\/wp\/v2\/media?parent=8"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}