{"id":1349,"date":"2022-10-13T17:37:32","date_gmt":"2022-10-13T21:37:32","guid":{"rendered":"https:\/\/labs.icahn.mssm.edu\/design\/?page_id=1349"},"modified":"2026-04-29T14:19:17","modified_gmt":"2026-04-29T18:19:17","slug":"home","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/bachilab\/","title":{"rendered":"Home"},"content":{"rendered":"

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How do biomarkers of early life adversity play lifelong roles in disease trajectory?<\/p>\n

[\/et_pb_slide][et_pb_slide heading=”Psychosocial factors” _builder_version=”4.27.4″ _module_preset=”default” header_text_align=”left” body_text_align=”left” background_image=”https:\/\/labs.icahn.mssm.edu\/placeholder4\/wp-content\/uploads\/sites\/634\/2022\/07\/ai-002-1.jpg” background_enable_image=”on” text_orientation=”left” custom_padding=”|||80px|false|false” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n

What are the impacts of adverse and protective psychosocial factors on brain structure and function?<\/p>\n

[\/et_pb_slide][et_pb_slide heading=”Neuroimmune mechanisms” _builder_version=”4.27.4″ _module_preset=”default” header_text_align=”left” body_text_align=”left” background_image=”https:\/\/labs.icahn.mssm.edu\/placeholder4\/wp-content\/uploads\/sites\/634\/2022\/07\/ai-002-1.jpg” background_enable_image=”on” text_orientation=”left” custom_padding=”|||80px|false|false” global_colors_info=”{}” sticky_transition=”on”]<\/p>\n

What are the immune mechanisms that link psychosocial factors and neurobiological markers?<\/p>\n

[\/et_pb_slide][\/et_pb_fullwidth_slider][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Two Column Image and Text over Button – Section 6 (Collections)” module_class=”section6_two_col_img_txt_over_btn” _builder_version=”4.16″ custom_margin=”30px||25px||false|false” custom_margin_tablet=”100px||||false|false” custom_margin_phone=”” custom_margin_last_edited=”on|desktop” custom_padding=”0px|0px|0px|0px|false|false” custom_css_main_element=”padding: 0px !important;” locked=”off” collapsed=”on” global_colors_info=”{}”][et_pb_row column_structure=”1_2,1_2″ make_equal=”on” _builder_version=”4.27.4″ width=”83.4%” module_alignment=”center” custom_margin=”|auto|0px|-32px||” custom_padding=”0px||0px|||” box_shadow_style=”preset1″ box_shadow_color=”#58595B” collapsed=”off” global_colors_info=”{}”][et_pb_column type=”1_2″ _builder_version=”4.16″ background_image=”https:\/\/labs.icahn.mssm.edu\/placeholder4\/wp-content\/uploads\/sites\/634\/2022\/08\/ai-008-bwSm-1.png” background_position=”center_right” custom_padding=”40px|40px|40px|40px|true|true” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text disabled_on=”off|off|off” _builder_version=”4.27.4″ header_font=”|700|||||||” header_text_color=”#221F72″ header_font_size=”36px” header_3_font=”|700|||||||” header_3_text_color=”#2b2b2b” header_3_font_size=”28px” header_3_line_height=”1.5em” custom_margin=”||10px|” custom_padding=”5%||||false|false” global_colors_info=”{}”]<\/p>\n

Our Research<\/strong><\/h1>\n

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Our multidisciplinary research focuses on the psychosocial pathways involved in disease progression and recovery in drug addiction and related psychiatric disorders, namely stress and emotion-regulation related psychopathologies. A systems approach transcending brain-periphery-environment factors is used to examine how psychosocial processes relate with neurobiological correlates of behavior.
Research is directed to advance understanding of:<\/p>\n

1) how biomarkers associated with early adversity play lifelong roles in disease trajectory;<\/p>\n

2) what are the impacts of adverse and protective psychosocial factors on brain structure and function in adults; and<\/p>\n

3) what are the immune mechanisms that link between psychosocial factors and neurobiological markers.<\/p>\n

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Multidisciplinary Approach<\/h1>\n

To investigate these questions, neuropsychological and behavioral assessments are used along with functional magnetic resonance imaging (fMRI), and analyzing peripheral biomarker assays. Through this work we seek to identify targetable mediators linking environment (stress) to psychiatric disorder and to facilitate the development of novel prevention strategies, diagnostic tools, and interventions.<\/p>\n

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Keren Bachi, Ph.D., LCSW\u00a0<\/strong>
Principal Investigator<\/h1>\n

Dr. Keren Bachi, PhD, LCSW, is a neuroscientist and a clinical trialist whose rich clinical background set the stage for her scientific path.\u00a0Dr. Bachi\u2019s research program centers on the investigation of neurobiological underpinnings of social factors \u2013\u00a0<\/span>primarily long term effects of early life adversity<\/i>\u00a0\u2013 across comorbidities including stress related disorders and addictions aimed to glean insights for novel prevention, early intervention, and treatments. The research questions Dr. Bachi studies build on her clinical observations coupled with scientific knowledge, facilitating a two-way bridge between clinic and research.\u00a0<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_2″ _builder_version=”4.16″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/labs.icahn.mssm.edu\/bachilab3\/wp-content\/uploads\/sites\/634\/2026\/03\/k.bachi-headshot.jpg” title_text=”k.bachi headshot” _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ disabled_on=”off|off|off” admin_label=”Footer Fullwidth – Section 13″ module_class=”footer-section” _builder_version=”4.27.4″ background_color=”#c7eafb” background_image=”https:\/\/labs.icahn.mssm.edu\/placeholder4\/wp-content\/uploads\/sites\/634\/2022\/10\/Rectangle-3.png” max_width=”100%” max_width_tablet=”” max_width_phone=”” max_width_last_edited=”on|phone” module_alignment=”center” custom_margin=”0px|||176px|false|false” custom_padding=”0px|0px|0px|0px|false|false” animation_style=”slide” animation_direction=”bottom” animation_intensity_slide=”14%” animation_starting_opacity=”100%” global_module=”3741″ saved_tabs=”all” locked=”off” collapsed=”on” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” header_text_color=”#FFFFFF” header_2_text_color=”#FFFFFF” global_colors_info=”{}”]<\/p>\n

Contact Us<\/strong><\/h2>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.16″ background_color=”RGBA(0,0,0,0)” background_color_gradient_direction=”38deg” module_alignment=”center” custom_margin=”|auto|-2px|auto||” custom_padding=”0px|||||” locked=”off” collapsed=”on” global_colors_info=”{}”][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”22px” custom_padding=”||0px|||” global_colors_info=”{}”]<\/p>\n

Lab Address<\/strong>
1399 Park Avenue
New York, NY 10029<\/span><\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.25em” header_font=”||||||||” header_4_font=”|700||on|||||” header_4_font_size=”16px” header_4_letter_spacing=”1px” header_4_line_height=”1.5em” background_layout=”dark” custom_margin=”|4px||||” locked=”off” global_colors_info=”{}”]<\/p>\n

E-mail
<\/strong>bachilab@mssm.edu<\/p>\n

Phone
<\/strong>Tel: 646-984-3519<\/p>\n

[\/et_pb_text][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.27.4″ text_font=”||||||||” text_text_color=”#FFFFFF” text_line_height=”1.25em” header_font=”||||||||” header_4_font=”|700||on|||||” header_4_font_size=”16px” header_4_letter_spacing=”1px” header_4_line_height=”1.5em” background_layout=”dark” locked=”off” global_colors_info=”{}”]<\/p>\n

Mailing Address <\/strong>
Bachi Lab
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place
Annenberg
New York, NY 10029<\/span><\/p>\n

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