{"id":18,"date":"2016-08-04T13:05:50","date_gmt":"2016-08-04T13:05:50","guid":{"rendered":"http:\/\/labs.icahn.mssm.edu\/akarlab\/?page_id=18"},"modified":"2020-02-26T17:15:19","modified_gmt":"2020-02-26T17:15:19","slug":"home","status":"publish","type":"page","link":"https:\/\/labs.icahn.mssm.edu\/akarlab\/","title":{"rendered":"Welcome to the Akar Laboratory"},"content":{"rendered":"<p><a href=\"https:\/\/labs.icahn.mssm.edu\/akarlab\/research\/picture1\/#main\" rel=\"attachment wp-att-103\">[wds id=&#8221;3&#8243;]<img loading=\"lazy\" decoding=\"async\" class=\"wp-image-103 aligncenter\" src=\"https:\/\/labs.icahn.mssm.edu\/akarlab\/wp-content\/uploads\/sites\/6\/2016\/08\/Picture1-300x204.png\" alt=\"Picture1\" width=\"474\" height=\"323\" srcset=\"https:\/\/labs.icahn.mssm.edu\/akarlab\/wp-content\/uploads\/sites\/6\/2016\/08\/Picture1-300x204.png 300w, https:\/\/labs.icahn.mssm.edu\/akarlab\/wp-content\/uploads\/sites\/6\/2016\/08\/Picture1-1024x695.png 1024w, https:\/\/labs.icahn.mssm.edu\/akarlab\/wp-content\/uploads\/sites\/6\/2016\/08\/Picture1.png 1426w\" sizes=\"auto, (max-width: 474px) 100vw, 474px\" \/><\/a><\/p>\n<p>The mission of the Akar Cardiac Bioelectricity Research laboratory at ISMMS is to uncover the mechanisms underlying sudden cardiac death across a variety of clinically relevant structural heart diseases. We use integrative tools that allow us to undertake a systems biology approach to the investigation of arrhythmia mechanisms and to test novel treatment strategies. A major focus of our work is the investigation of abnormalities in impulse formation, conduction, and repolarization in heart failure, and the elucidation of underlying cellular and molecular mechanisms, using state-of-the-art electrophysiological, biochemical, and molecular techniques. Specific areas of active research include mechanisms of mechano-electrical feedback, the electrophysiology of mechanical dyssynchrony and resynchronization therapy in canine and porcine models of heart failure, the interaction of myocardial energetics and electrical function in post-ischemic remodeling and reperfusion related arrhythmias, and the role of altered gene expression and targeted gene delivery on ion channel function and arrhythmogenesis in cardiovascular diseases. <a href=\"https:\/\/labs.icahn.mssm.edu\/akarlab\/research\/\">Read more.<\/a><\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>[wds id=&#8221;3&#8243;] The mission of the Akar Cardiac Bioelectricity Research laboratory at ISMMS is to uncover the mechanisms underlying sudden cardiac death across a variety of clinically relevant structural heart diseases. We use integrative tools that allow us to undertake a systems biology approach to the investigation of arrhythmia mechanisms and to test novel treatment [&hellip;]<\/p>\n","protected":false},"author":146,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-18","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/labs.icahn.mssm.edu\/akarlab\/wp-json\/wp\/v2\/pages\/18","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/labs.icahn.mssm.edu\/akarlab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/labs.icahn.mssm.edu\/akarlab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/akarlab\/wp-json\/wp\/v2\/users\/146"}],"replies":[{"embeddable":true,"href":"https:\/\/labs.icahn.mssm.edu\/akarlab\/wp-json\/wp\/v2\/comments?post=18"}],"version-history":[{"count":56,"href":"https:\/\/labs.icahn.mssm.edu\/akarlab\/wp-json\/wp\/v2\/pages\/18\/revisions"}],"predecessor-version":[{"id":435,"href":"https:\/\/labs.icahn.mssm.edu\/akarlab\/wp-json\/wp\/v2\/pages\/18\/revisions\/435"}],"wp:attachment":[{"href":"https:\/\/labs.icahn.mssm.edu\/akarlab\/wp-json\/wp\/v2\/media?parent=18"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}