Publications

  • Esposito, D., Pant, I., Shen, Y., Qiao, R.F., Yang X., Bai, Y., Jin, J., Poulikakos, P.I., and Aaronson, S.A., ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation. Nature Communications (2022) 13:703 https://doi.org/10.1038/s41467-022-28319-3
  • Rogic, A., Pant, I., Grumolato, L., Fernandez-Rodriguez, R., Edwards, A., Das, S., Sun, A. Yao, S., Qiao, R., Jaffer, S., Sachidanandam, R., Akturk, G., Karlic, R., Skobe, M., and Aaronson, S.A. High endogenous CCL2 expression promotes the aggressive phenotype of human inflammatory breast cancer. Nature Communications 2021. 12:6889  https://doi.org/10.1038/s41467-021-27108-8.
  • Adamopoulos, C., Ahmed, T.A., Tucker, M.R., Ung, P.M.U., Xiao, M., Karouia, Z., Amabile, A., Wu, X., Aaronson, S.A., Ang, C., Vito, W.R., Brown, B.D., Schlessinger, A., Herlyn, M., Wang, Q., Shaw, D.E., and Poulikakos, P.I. Exploiting allosteric properties of RAF and MEK inhibitors to target therapy-resistant tumors driven by oncogenic BRAF signaling. Cancer Discovery 2021. Published Online First on February 10, 2021 DOI: 10.1158/2159-8290.CD-20-1351
  • Wu, X., Yang, X., Xiong, Y., Li, R., Ito, T., Ahmed, T.A. Karoulia, Z., Adamopoulos, C., Wang, H. Wang, L. Xie, L., Liu, J., Ueberheide, B, Aaronson, S.A., Xhen, X., Buchanan, S.G., Sellers, W.R., Jin, J. and Poulikakos, P.I. D Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders. Nature Cancer 2021 2: 429-443.
  • Ahmed, T., Adamopoulos, C., Karoulia, Z., Wu, X., Sachidanandam, R., Aaronson, S.A., Poulikakos, PI.  SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors.  Cell Rep. 2019 Jan 2;26(1):65-78. E5.doi:10.1016/j.celrep.2018.12.03.
  • Vijayakumar, S., Liu, L., Wen, H-C., Abu, Y,  Chong, R., Nastri, H., Bornstein, G.G., Pan, Z-Q., and  Aaronson, S.A.   Extracellular LDLR repeats modulate Wnt signaling activity by promoting LRP6 receptor endocytosis mediated by the Itch E3 ubiquitin ligase.   Genes & Cancer, 2017 8(7) 613-624 PMCID:  PMC5620007.
  • Munoz-Fontela, C. Mandinova, A., Aaronson, S.A., Lee, S. W., Emerging roles of p53 and  other tunour-suppressor genes in immune regulation Nat Rev Immunol. 2016 Dec;16(12):741- 750. doi: 10.1038/nri.2016.99. Epub 2016 Sep 26. PMC5325695
  • Guernet A, Mungamuri SK, Cartier D, Sachidanandam R, Jayaprakash A, Adriouch S, Vezain M, Charbonnier F, Rohkin G, Coutant S, Yao S, Ainani H, Alexandre D, Tournier I, Boyer O5, Aaronson SA, Anouar Y1, Grumolato L. CRISPR-Barcoding for Intratumor Genetic Heterogeneity Modeling and Functional Analysis of Oncogenic Driver Mutations. Mol Cell. 2016 Aug 4;63(3):526-38. doi: .1016/j.molcel.2016.06.017. Epub 2016 Jul 21 PMCID: PMC5537739
  • Troilo, A., Benson, EK., Esposito, D, Garibsingh, R-A., Reddy, PK., Mungamuri, SK., Aaronson, S.A.  Angiomotin stabilization by tankyrase inhibitors antagonizes constitutive TEAD-dependent transcription and proliferation of human tumor cells with Hippo pathway core component mutations. Oncotarget 2016 Apr 29. doi: 10.18632/oncotarget.9117. [Epub ahead of print] PMID: 27144834
  • Mungamuri, SK., Quio, R., Yao, S., Manfredi, JJ., Gu, W. and Aaronson, S.A., USP7            enforces heterochromatinization of P53 target promoters by protecting SUV39H1 from MDM2-mediated degradation. Cell Reports 2016 Mar 22;14(11);2528-37 Epub 2016 Mar 10 PMCID: PMC4884055
  • Kracikova, M., Akiri, G, George, A., Sachidanandam, R., and Aaronson S.A.   A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis. Cell Death Differ. 2013  Jan 11. doi: 10.1038/cdd.2012.155. [Epub ahead of print] PMID: PMC3595483
  • Muñoz-Fontela C1, Pazos M, Delgado I, Murk W, Mungamuri SK, ta, García-Sastre A, Moran TM, and Aaronson S.A.  p53 serves as a host antiviral factor that enhances innate and adaptive immune responses to influenza A virus. J Immunol. 2011 Dec 15; 187;6428-6436. PMID: PMCID3275346
  • Mungamuri, S.K., Benson, E.K., Wang, S., Gu, W., Lee, S.W, and Aaronson, S.A.  Tumor suppressor p53-mediated heterochromatin reorganization regulates its cell fate decisions. Nat Struct Mol Biol. 2012 Apr 1. doi: 10.1038/nsmb.2271. [Epub ahead of print]  PMID: 22466965