Publications

Zhiqiang Deng, Kerry Purtell, Veronik Lachance, Mitchell Wold, Shi Chen and Zhenyu Yue (2017)  Autophagy receptors and Neurodegeneration”  Trends in Cell Biology

Jinglan Zhang, Véronik Lachance, Adam Schaffner, Anastasia Fedick, Jun Liao, Jill Rosenfeld, Naomi Yachelevich, Mary-Lynn Chu, Wendy Mitchell, Richard Boles, Ellen Moran, Elizabeth Gorman, Kaytee Bagley, Wei Zhang, Fan Xia, Magalie Leduc, Yaping Yang, Christine Eng, Lee-Jun Wong, Raphael Schiffmann, George A. Diaz, Ruth Kornreich, Melissa Wasserstein, Zhenyu Yue*, Lisa Edelmann *(*co-corresponding author)  A Founder Mutation in VPS11 Causes an Autosomal Recessive Leukoencephalopathy Linked to Autophagic Defects (2016)  PLoS Genetics

Mitchell S. Wold, Junghyun Lim, Véronik Lachance, Zhiqiang Deng, Zhenyu Yue (2016) ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington’s disease models Molecular Neurodegeneration 

Lim J, Lachenmayer ML, Wu S, Liu W, Kundu M, Wang R, Komatsu M, Oh YJ, Zhao Y, Yue Z. Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates.PLoS Genet. 2015

Lim J, Yue Z. Neuronal Aggregates: Formation, Clearance, and Spreading. Dev Cell. 2015 Feb 23

McKnight NC, Zhong Y, Wold MS, Gong S, Phillips GR, Dou Z, Zhao Y, Heintz N, Zong WX, Yue Z. Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex. PLoS Genet. 2014

Lu J, He L, Behrends C, Araki M, Araki K, Jun Wang Q, Catanzaro JM, Friedman SL, Zong WX, Fiel MI, Li M, Yue Z. NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity. Nature communications 2014

Tang G, Gudsnuk K, Kuo SH, Cotrina ML, Rosoklija G, Sosunov A, Sonders MS, Kanter E, Castagna C, Yamamoto A, Yue Z, Arancio O, Peterson BS, Champagne F, Dwork AJ, Goldman J, Sulzer D. Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits. Neuron 2014

Friedman AK, Walsh JJ, Juarez B, Ku SM, Chaudhury D, Wang J, Li X, Dietz DM, Pan N, Vialou VF, Neve RL, Yue Z, Han MH. Enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience. Science (New York, N.Y.) 2014

Yang Y, Coleman M, Zhang L, Zheng X, Yue Z (2013). Autophagy in axonal and dendritic degeneration. Trends in Neuroscience. 2013

Bezard E, Yue Z, Kirik D, Spillantini MG (2013). Animal Models of Parkinson Disease: limits and relevance to neuroprotection studies. Movement Disorders 28(1):61-70.

Konishi A, Arakawa S, Yue Z, Shimizu S. (2012) Involvement of Beclin 1 in the engulfment of apoptotic cells. The Journal of Biological Chemistry

Friedman L, Lachenmayer L, Wang J, He L, Poulose S, Komatsu M, Holstein G, Yue Z. (2012) Disrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of a-synuclein and LRRK2 in the brain. The Journal of Neuroscience 2012 

McMahon J, Huang X, Yang J, Komatsu M, Yue Z, Qian J, Zhu X, Huang Y. (2012) Impaired autophagy in neurons following disinhibition of mTOR and its contribution to epileptogenesis. Journal of Neuroscience

Steele JW, Lachenmayer ML, Ju S, Stock A, Liken J, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Fraser P, Westaway D, St George-Hyslop PH, Szabo P, Relkin NR, Buxbaum JD, Glabe CG, Protter AA, Martins RN, Ehrlich ME, Petsko GA, Yue Z, Gandy S. (2012) Latrepirdine improves cognition and arrests progression of neuropathology in an Alzheimer’s mouse model. Molecular Psychiatry. 2012

Steele JW, Ju S, Lachenmayer ML, Liken J, Stock A, Kim SH, Delgado LM, Alfaro IE, Bernales S, Verdile G, Bharadwaj P, Gupta V, Barr R, Friss A, Dolios G, Wang R, Ringe D, Protter AA, Martins RN, Ehrlich ME, Yue Z, Petsko GA, Gandy S. (2012) Latrepirdine stimulates autophagy and reduces accumulation of α-synuclein in cells and in mouse brain. Molecular Psychiatry. 2012

Bharadwaj PR, Verdile G, Barr RK, Gupta V, Steele JW, Lachenmayer ML, Yue Z, Ehrlich ME, Petsko G, Ju S, Ringe D, Sankovich SE, Caine JM, Macreadie IG, Gandy S, Martins RN. (2012) Latrepirdine (Dimebon™) Enhances Autophagy and Reduces Intracellular GFP-Aβ42 Levels in Yeast. J Alzheimers Dis. 2012

Li X, He L, Che KH, Funderburk SF, Pan L, Pan N, Zhang M, Yue Z*, Zhao Y*. (2012) Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG. Nature Communications

Yang CS, Lee JS, Rodgers M, Min CK, Lee JY, Kim HJ, Lee KH, Kim CJ, Oh B, Zandi E, Yue Z, Kramnik I, Liang C, Jung JU. (2012) Autophagy Protein Rubicon Mediates Phagocytic NADPH Oxidase Activation in Response to Microbial Infection or TLR Stimulation. Cell Host & Microbe

Hernández-Gea V, Ghiassi-Nejad Z, Rozenfeld R, Gordon R, Fiel MI, Yue Z, Czaja MJ, Friedman SL. (2012) Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues. Gastroenterology

Yu Z, Wang AM, Adachi H, Katsuno M, Sobue G, Yue Z, Robins DM, Lieberman AP. (2011) Macroautophagy is regulated by the UPR-mediator CHOP and accentuates the phenotype of SBMA mice. PLoS Genetics

Morris S, Swanson MS, Lieberman A, Reed M, Yue Z, Lindell DM, Lukacs NW. (2011) Autophagy-mediated dendritic cell activation is essential for innate cytokine production and APC function with respiratory syncytial virus responses. The Journal of Immunology

Suárez AL, Kong R, George T, He L, Yue Z, van Dyk LF. (2011) Gammaherpesvirus 68 infection of endothelial cells requires both host autophagy genes and viral oncogenes for optimal survival and persistence. Journal of Virology

Li X, Wang QJ, Pan N, Lee S, Zhao Y, Chait BT, Yue Z. (2011) Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson’s disease. PLoS One

Arsov I, Adebayo A, Kucerova-Levisohn M, Haye J, Macneil M, Papavasiliou FN, Yue Z, Ortiz BD. (2011) A role for autophagic protein beclin 1 early in lymphocyte development. The Journal of Immunology

Dou Z, Chattopadhyay M, Pan JA, Guerriero JL, Jiang YP, Ballou LM, Yue Z, Lin RZ, Zong WX. (2010) The Class IA phosphatidylinositol 3-kinase p110ß subunit is a positive regulator of autophagy. The Journal of Biological Chemistry

Li X, Patel JC, Wang J, Avshalumov MV, Nicholson C, Buxbaum JD, Elder GA, Rice ME, Yue Z. (2010) Enhanced striatal dopamine transmission and motor performance with LRRK2 overexpression in mice is eliminated by familial Parkinson’s disease mutation G2019S. The Journal of Neuroscience

Zhong Y, Wang QJ, Li X, Chait BT, Heintz N, and Yue Z. (2009) Distinct Regulation of Autophagic Activity by Novel Components Atg14L and Rubicon in Beclin 1-Vps34/phosphatidylinositol (PtdIns) 3-kinase complex. Nature Cell Biology

Arsov I, Li X, Matthews G, Coradin J, Hartmann B, Simon AK, Sealfon SC, Yue Z. (2008) BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte development. Cell Death and Differerentiation

Tang G, Yue Z, Talloczy Z, Hagemann T, Cho W, Messing A, Sulzer DL, Goldman JE. (2008) Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways. Human Molecular Genetics

Komatsu M, Waguri S, Koike M, Sou YS, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E, Tanaka K. (2007) Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell

Ullman E, Fan Y, Stawowczyk M, Chen HM, Yue Z, Zong WX. (2007) Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress. Cell Death and Differentiation; 2008

Komatsu M, Wang QJ, Holstein GR, Friedrich VL Jr, Iwata J, Kominami E, Chait BT, Tanaka K, Yue Z. (2007) Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proceedings of the National Academy of Sciences USA

Wang QJ, Ding Y, Kolhz DS, Mizushima N, Cristea IM, Rout MP, Chait BT, Zhong Y, Heintz N, Yue Z. (2006) Induction of autophagy in axonal dystrophy and degeneration. The Journal of Neuroscience

Yue Z, Jin S, Yang C, Levine AJ, Heintz N. (2003) Beclin1, an autophagy gene essential for early embryonic development, is a haplo-insufficient tumor suppressor. Proceedings of the National Academy of Sciences USA

Yue Z, Horton A, Bravin M, DeJager PL, Selimi F, Heintz N. (2002) A Novel Protein Complex linking the d2 Glutamate Receptor (GluRd2) and Autophagy: Implications for Neurodegeneration in Lurcher Mice. Neuron