Tristan Jordan

Tristan is a postdoctoral fellow with interests in the cell biology of virus-host interactions and the evolutionary pressures exerted on RNA viruses by different antiviral systems. He currently works to a) adapt different RNA dependent RNA polymerases to mammalian systems in addition to engineering a toolbox of viruses to elucidate various aspects of the host response to virus infection, and b) understand how Drosha restricts positive strand RNA viruses. During graduate school, he worked in the lab of Glenn Randall where he focused on understanding how dengue virus modulates cellular signaling pathways to initiate a proviral, lipid droplet-specific autophagy program (lipophagy).

 

Contact:  Tristan.Jordan@mssm.edu

 

 

 

 


Publications:

Aguado L, Jordan, T Hsieh E, Blanco-Melo D, Heard J, Panis M, Vignuzzi M, tenOever BR. Homologous recombination is an intrinsic defense against antiviral RNA interference. PNAS 2018. In Press.

Tristan X. Jordan, and Glenn Randall. AMPK-inhibition of mTORC1 signaling is required for dengue virus-induced lipophagy. 2017. J Virol. 91(11):e02020-16.

Tristan X. Jordan, and Glenn Randall. Flavivirus modulation of cellular metabolism. 2016. Curr Opin Virol. 19:7-10.

Tristan X. Jordan, and Glenn Randall. Flaviviruses and Autophagy. In  Autophagy, Infection, and the Immune Response. Eds. Jackson, WT,  Swanson MS. Wiley Blackwell; 2015:81-100.

Tristan X. Jordan, and Glenn Randall.  Manipulation or capitulation: Virus interactions with autophagy. 2012. Microbes Infect. 14(2):126-39.

Kristi L. Berger, Sean M. Kelly, Tristan X. Jordan, Michael A Tartell, and Glenn Randall. Hepatitis C Virus stimulates the phosphatidylinositol 4-kinase III alpha dependent production of phosphatidylinositol 4-phosphate production that is essential for replication. 2011. J Virol. 85(17):8870-83.

Kristi L. Berger, Jake D. Cooper, Nicholas S. Heaton, Rosa Yoon, Todd E. Oakland, Tristan X. Jordan, Guaniri Mateu, Arash Grakoui, and Glenn Randall. 2009. Roles for endocytic trafficking and phosphatidylinositol 4-kinase III alpha in hepatitis C virus replication. 2009. Proc Natl Acad Sci U S A. 106(18):7577-82.