Publications

Eggenberger J, Blanco-Melo D, Panis M, Brennand KJ, tenOever BR.  Type I interferon response impairs differentiation potential of pluripotent stem cells.  PNAS 2019. https://doi.org/10.1073/pnas.1812449116.  Download

Aguado L, Jordan T, Hsieh E, Blanco-Melo D, Heard J, Panis M, Vignuzzi M, tenOever BR. Homologous recombination is an intrinsic defense against antiviral RNA interference. PNAS 2018. doi: 10.1073/pnas.1810229115. Download

Moeller R, Schwarz TM, Noriega VM, Panis M, Sachs D, Tortorella D, tenOever BR.  miRNA-mediated targeting of human cytomegalovirus reveals biological host and viral targets of IE2.  PNAS.  2018 Jan 30;115(5):1069-1074. doi: 10.1073/pnas.1719036115. Download

Han J, Perez JT, Chen C, Li Y, Benitez A, Kandasamy M, Lee Y, Andrade J, tenOever B, Manicassamy B. Genome-wide CRISPR/Cas9 screen identifies host factors essential for influenza A virus replication. Cell Reports. 2018 Apr 10;23(2):596-607. doi: 10.1016/j.celrep.2018.03.045. Download

Aguado LC, tenOever BR. RNase III Nucleaes and the Evolution of Antiviral Systems. Bioessays. 2018 Feb;40(2). doi: 10.1002/bies.201700173.  Download

Aguado LC, Schmid S, May J, Sabin LR, Panis M, Blanco-Melo D, Shim JV, Sachs D, Cherry S, Simon AE, Levraud JP, tenOever BR.  RNase III nucleases from diverse kingdoms serve as antiviral effectors.  Nature.  2017  Jul 6;547(7661):114-117.  PMID 28658212  Download

Aguado LC, tenOever BR.  RNase III nucleases and the evolution of antiviral systems.  Bioessays.  2017  Dec 21 doi: 10.1002/bies.20170173.  PMID 29266287  Download

Wohlbold TJ, Podolsky KA, Chromikova V, Kirkpatrick E, Falconieri V, Meade P, Amanat F, Tan J, tenOever BR, Tan GS, Subramaniam S, Palese P, Krammer F. Broadly protective murine monoclonal antibodies against influenza A virus target highly conserved neuraminidase epitopes. Nat Microbiol. 2017;10:1415. doi: 10.1038/s41564-017-0011-8. PMID: 28827718. Download

Duehr J, Wohlbold TJ, Oestereich L, Chromikova V, Amanat F, Rajendran M, Gomez-Medina S, Mena I, tenOever BR, García-Sastre A, Basler CF, Munoz-Fontela C, Krammer F. Novel cross-reactive monoclonal antibodies against Ebolavirus glycoproteins show protection in a murine challenge model.  J Virol. 2017. Jun 7. pii: JVI.00652-17 PMID: 28592526  Download

tenOever BR.  Questioning antiviral RNAi in mammals.  Nat.  Microbiology.  2017  Apr 25;2:17052 PMID: 28440277 Download

Beaty SM, Park A, Won ST, Hong P, Lyons M, Vigant F, Freiberg AN, tenOever BR, Duprex WP, Lee B.  Efficient and Robust Paramyxoviridae Reverse Genetics Systems.  mSphere. 2017 Mar 29;2(2). pii: e00376-16. PMID: 28405630 Download

Morales, L., Oliveros, JC., Fernandez-Delgado, R., tenOever, BR., Enjuanes, L. and Sola, I. Contribution of host and viral small non-coding RNAs to SARS-CoV lung pathology. Cell Host & Microbe 2017, Mar 8;21(3):344-355.  PMID: 28216251 Download

Thapa, RJ., Ingram, JP., Ragan, KB., Nogusa, S., Boyd, DF., Benitez, AA., tenOever, BR., Thomas, PG., Upton, JW., and Balachandran, S.  DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death.  Cell Host & Microbe  2016 Nov 9;20(5):674-681. doi: 10.1016/j.chom.2016.09.014. PMID 27746097  Download

B.R. tenOever. The Evolution of Antiviral Defense Systems. Cell Host & Microbe. 2016, 19(2), 142-149. PMID: 26867173  Download

Aguado, L.C., Schmid, S., Sachs, D., Shim, J.V., Lim, J.K., and B.R. tenOever. microRNA function is limited to cytokine control in the acute response to virus. Cell Host & Microbe. 2015, 18, 714-722. PMID: 26651947  Download

Benitez A.A., Spanko, L.A., Bouhaddou, M., Panis, M., Sachs, D. and B.R. tenOever. Engineered mammalian RNAi can elicit antiviral protection that negates the requirements for the interferon response. Cell Reports. 2015, Nov 17;13(7):1456-66. PMID: 26549455  Download

Benitez A.A., Panis, M., Xue, J., Varble, A., Shim, J.V., Frick, A.L., López, C.B., Sachs, D. and B.R. tenOever. In Vivo RNAi Screening Identifies MDA5 as a Significant Contributor to the Cellular Defense against Influenza A Virus. Cell Reports. 2015,11(11):1714-26. PMID 26074083 Download

Varble, A., Albrecht, R.A., Backes, S., Crumiller, M., Bouvier, N.M., Sachs, D. Garcia-Sastre, A., and B.R. tenOever. Influenza A Virus Transmission Bottlenecks Are Defined by Infection Route and Recipient Host. Cell Host & Microbe. 2014,16(5): 691-700 PMID 25356074 Download

Heaton, N.S., Langlois R., Sachs, D., Lim, J., Palese, P., and B.R. tenOever. Long-term survival of influenza virus infected club cells drives immunopathology. Journal of Experimental Medicine. 2014, 211(9):1707-14 PMID 25135297  Download

Laurent-Rolle, M., Morrisone, J. Rajsbaum, R., Macleod, JL, Pisanelli, G., Miorin, L, Pham, A., Ayllon, J., tenOever, B.R. and A. Garcia-Sastre. Type I interferon activates the interferon signaling antagonist function of yellow fever virus NS5 protein. Cell Host & Microbe. 2014,16(3): 314-327 PMID 25211074  Download

Moy, R.H., Cole, B.S., Yasunaga, A., Gold, B., Shankarling, G., Varble, A., Molleston, J., tenOever, B.R., Lynch, K.W., Cherry, S. Stem loop recognition by DDX17 facilitates miRNA processing and antiviral defense. Cell. 2014 158(4):764-77 PMID 25126784 Download

Rajsbaum, R., Versteeg, G.A., Schmid, S., Maestre, A.M. Belicha-Villanueva, A., Martinez-Romero, C., Patel, J.A., Morrison, J., Pisanelli, G., Miorin, L., Laurent-Rolle, M.m Moulton, H.M., Stein, D.A., Fernandez-Sesma, A., tenOever, B.R., and A. Garcia-Sastre. Unanchored K48-linked poly-ubiquitin synthesized by the E3-ubiquitin ligase TRIM6 stimulates the interferon-IKKe kinase mediated antiviral response. Immunity. 2014 40(6):880-95 PMID: 24882218 Download

Backes, S., Langlois, R., Schmid, S., Varble, A, Shim, J.V., Sachs, D., and B.R. tenOever. The mammalian response to virus infection is independent of small RNA silencing. Cell Reports. 2014 (14)1-9 PMID: 249536 Download

Shapiro, J.S., Schmid, S., Aguado, L., Sabin, L.R., Cherry, S. and B.R. tenOever. Drosha is an interferon-independent antiviral factor. PNAS. 2014. 111(19): 7108-7113. PMID: 24778219 Download

Schmid, S. Zony, X., and B.R. tenOever. A versatile RNA vector for delivery of coding and non-coding RNAs. Journal of Virology. 2014, 88(4), 2333-6. PMID: 24307584 Download

Schmid, S. Sachs, D., and B.R. tenOever. MAP Kinase Mediated Licensing of Interferon Regulatory Factor 3/7 Reinforces the Cell Response to Virus. JBC. 2014, 3 (289): 299-311. PMID: 24275658 Download

Cullen, B. Cherry, S. and B.R. tenOever. Is RNA interference a physiological relevant innate antiviral immune response in mammals. Cell Host & Microbe. 2013, 14, 374-375. PMID: 24139396 Download

Varble, A., Benitez, A., Schmid, S., Sachs, D., Shim, JV, Rodriguez-Barrueco, R., Panis, M., Crumiller, M., Silva, J., Sachidanandam, R. and B.R. tenOever. RNAi screening in vivo identifies critical components to the antiviral response. Cell Host & Microbe. 2013, 14, 346-356. PMID: 24034620 Download

Langlois, R.A, Albrecht, R., Kimble, B., Sutton, T., Shapiro, J., Finch, C., Angel, M., Chua, M.A. Gonzalez-Reiche, A., Xu, K., Perez, D., García-Sastre, A. and B.R. tenOever. Molecular risk mitigation of gain-of-function studies with influenza viruses. Nature Biotechnology. 2013, Aug, 31, 844-847. PMID: 23934176 Download

tenOever, B.R. RNA viruses and the host microRNA machinery. Nature Reviews Microbiology. 2013, 11(3): 169-80. PMID: 23411862 Download

Chua, M.A., Schmid, S., Perez, J.T., Langlois, R.A. and B.R. tenOever. Influenza A Virus Utilizes Suboptimal Splicing to Coordinate the Timing of Infection. Cell Reports. 2013, 3(1) 23-39. PMID: 23333274  Download

 

Perez, J.T., Zlatev, I., Aggarwal, S., Subramanian, S., Sachidanandam, R., Kim, B., Manoharan, M. and B.R. tenOever. A Small RNA Enhancer of Viral Polymerase Activity. Journal of Virology. 2012, Dec;86(24): 13475-85. PMID: 23035211  Download

Backes, S., Shapiro, J.S., Sabin, L.R., Pham, A.M. Reyes, I., Moss, B., Cherry*, S. and B.R. tenOever*. Degradation of host microRNAs by a viral poly(A) polymerase reveals terminal 2’-O-methylation as a protective anti-viral mechanism. Cell Host and Microbe. 2012, Aug;12(2): 200-210. PMID: 22901540  Download

Langlois, R.A., Varble, A., Chua, M.A., García-Sastre, A. and B. R. tenOever. Hematopoietic-specific targeting of influenza A virus reveals replication requirements for induction of antiviral immune response. PNAS. 2012, Jul;109(30): 1338-46. PMID: 22778433  Download

Shapiro, J.S., Langlois, R.A., Pham, A.M. and B. R. tenOever. Evidence for a cytoplasmic microprocessor of pri-miRNAs. RNA. 2012, Jul;18(7): 1338-46. PMID: 22635403  Download

Pham, A.M., Langlois, R.A. and B. R. tenOever. Replication in cells of hematopoietic origin is necessary for dengue virus dissemination. PLoS Path. 2012, Jan;8(1). PMID: 22241991 Download

Ng, S.L., Friedman, B.A., Schmid, S., Gert, J, Myers, R.M., Maniatis, T., and B. R. tenOever. IKKe regulates the balance between the type I and type II interferon responses. PNAS. 2011, Dec 27; (108)(52):21170-5. PMID: 22171011  Download

Langlois, R.A., Shapiro, J.S., Pham, A.M. and B. R. tenOever. in vivo delivery of cytoplasmic RNA virus-derived miRNAs. Mol. Ther. 2011, Nov. 15,(20)(2):367-75. PMID: 22086233  Download

Schmid, S., Mordstein, M., Kochs, G., García-Sastre, A. and B. R. tenOever. Transcription factor redundancy ensures induction of the antiviral state. JBC. 2010, 285(53): 42013-22. PMID: 20943654  Download

Varble, A., M. A. Chua, J. T. Perez, B. Manicassamy, A. García-Sastre, and B. R. tenOever. Engineered RNA viral synthesis of microRNAs. PNAS. 2010, 107(25):11519-24. PMID: 20534531  Download

Shapiro, J.S., A. Varble, and B. R. tenOever. Non-canonical cytoplasmic processing of viral microRNAs. RNA. 2010, 16: 2068-74. PMID: 20841420  Download

Perez, J. T., A. Varble, R. Sachidanandam, I. Zlatev, M. Manoharan, A. García-Sastre, and B. R. tenOever. Influenza A Virus-Generated Small RNAs Regulate the Switch from Transcription to Replication. PNAS. 2010, 107(25):11525-30. PMID: 20534471  Download

Perez, JT., Pham, AM., Lorini, MH., Chua, MA., Steel, J., and BR. tenOever. microRNA-mediated species-specific attenuation of influenza A virus. Nat Biotech. 2009, 27: 572-576. PMID: 19483680  Download