PUBLICATIONS

He F, Soriano P (2017). Dysregulated PDGFRα signaling alters coronal suture morphogenesis and leads to craniosynostosis through endochondral ossification. Development 144, 4026-4036. PubMed

Fantauzzo KA, Soriano P (2017). Generation of an immortalized mouse embryonic palatal mesenchyme cell line. PLoS ONE 12, e1079078. PubMed

Molotkov A, Mazot P, Brewer JR, Cinalli RM, Soriano P (2017). Distinct roles for FGFR1 and FGFR2 in primitive endoderm development and exit from pluripotency. Developmental Cell 41, 511-526. PubMed

Fantauzzo KA, Soriano P (2016). PDGFRβ regulates craniofacial development through homodimers and functional heterodimers with PDGFRα. Genes and Development 30, 2443-58. PubMed

Brewer JR, Mazot P, Soriano P (2016). Genetic insights into the mechanisms of Fgf signaling. Genes and Development 30, 751-771. PubMed

Vasudevan HN, Soriano P (2016). A thousand and one receptor tyrosine kinases: wherein the specificity? Current Topics in Developmental Biology 117, 393-404. PubMed

Lewis AE, Hwa J, Wang R, Soriano P, Bush JO (2015). Neural crest defects in ephrin-B2 mutant embryos are non-autonomous and originate from defects in the vasculature. Dev. Biol. 406, 186-195. PubMed

Brewer JR, Molotkov A, Mazot P, Hoch RV, Soriano P (2015). Fgfr1 regulates development through the combinatorial use of signaling proteins. Genes and Development 29, 1863-1874. PubMed

He F, Soriano P (2015). Sox10ERT2CreERT2 mice enable tracing of distinct neural crest cell populations. Developmental Dynamics 244, 1394-1403. PubMed

Vasudevan HN, Mazot P, He F, Soriano P (2015). Receptor tyrosine kinases modulate distinct transcriptional programs by differential usage of intracellular pathways. eLife 4, e07186. PubMed

Hoch RV, Soriano P (2015). Generating diversity and specificity through developmental cell signaling. In Principles of Developmental Genetics (S.A. Moody Editor), 2nd Ed., Elsevier, pp.3-36.

Zou H, Feng R, Huang Y, Tripodi J, Najfeld V, Tsankova NM, Jahanshahi M, Olson LE, Soriano P, Friedel RH (2015). Double minute amplification of mutant PDGF receptor α in a mouse glioma model. Scientific Reports 5, 8468. PubMed

Fantauzzo KA, Soriano P (2015). Receptor tyrosine kinase signaling: regulating neural crest development one phosphate at a time. Current Topics in Developmental Biology 111, 135-182. PubMed

Vasudevan HN, Soriano P (2014). SRF regulates craniofacial development through selective recruitment of MRTF cofactors by PDGF signaling. Developmental Cell 31, 332-344. PubMed

Fantauzzo KA, Soriano P (2014). PI3K-mediated PDGFRα signaling regulates survival and proliferation  in skeletal development through p53-dependent intracellular pathways. Genes and Development 28, 1005-1017. PubMed

He F, Soriano P (2013). A critical role for PDGFRα signaling in medial nasal process development. PLoS Genetics 9, e1003851. PubMed

Friedel RH, Friedel CC, Bonfert T, Shi R, Rad R, Soriano P (2013). Clonal expansion analysis of transposon insertions by high-throughput sequencing identifies candidate cancer genes in a PiggyBac mutagenesis screen. PLoS ONE 8, e72338. PubMed

Lewis AE, Vasudevan HN, O’Neill AK, Soriano P, Bush JO (2013). The widely used Wnt1-Cre transgene causes developmental phenotypes by ectopic activation of Wnt signaling. Developmental Biology 379, 229-234. PubMed

Bush JO, Soriano P (2012). Eph/ephrin signaling: Genetic, phosphoproteomic and transcriptomic approaches. Semin Cell Dev Biol. 23 26-34. PubMed

Olson LE, Soriano P (2011). PDGFRβ signaling regulates mural cell plasticity and inhibits fat development. Developmental Cell 20, 815-826. PubMed

Bush JO, Soriano P (2010). Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries.  Genes and Development 24, 2068-2080. PubMed

Raymond CS, Soriano P (2010). ROSA26Flpo deleter mice promote efficient inversion of conditional gene traps in vivo. Genesis 48, 603-606. PubMed

Friedel RH, Soriano P (2010). Gene trap mutagenesis in the mouse. Methods in Enzymology 477, 243-269. PubMed

Olson LE, Soriano P (2009). Increased PDGFRα activation disrupts connective tissue development and drives systemic fibrosis. Developmental Cell 16, 303-313. PubMed

Bush JO, Soriano P (2009). Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism. Genes and Development 23, 1586-1599. PubMed

Schmahl J., Rizzolo, K. and P. Soriano. (2008). The PDGF signaling pathway controls multiple steroid producing lineages. Genes and Development, 22, 3255-67. PubMed

Qiu, R., Wang, X., Davy, A., Wu, C., Murai, K., Zhang, H., Flanagan, J.G., Soriano, P., and Lu, Q. (2008). Regulation of neural progenitor cell state by ephrin-B. J. Cell Biol., 181, 973-983. PubMed

Davy, A. and Soriano, P. (2007). Ephrin-B2 forward signaling regulates somite patterning and neural crest cell development. Dev Biol., 308, 182-193. PubMed

Raymond, C.S. and Soriano, P. (2007). High-Efficiency FLP and PhiC31 Site-Specific Recombination in Mammalian Cells. PLoS ONE, 2, e162. PubMed

Schmahl, J., Raymond, C.S., Soriano, P. (2007). PDGF signaling specificity is mediated through multiple immediate early genes. Nature Genetics, 39, 52-60. PubMed

Davy, A., Bush, J.O., Soriano, P. (2006). Inhibition of gap junction communication at ectopic Eph/ephrin boundaries underlies Craniofrontonasal Syndrome. PLoS Biology, 4, 1763-1776. PubMed

Raymond, C.S. and Soriano, P. (2006). Engineering Mutations: deconstructing the mouse gene by gene.  Developmental Dyn., 235, 2424-36. PubMed

Hoch, R.V. and Soriano, P. (2006). Context-specific requirements for Fgfr1 signaling through Frs2 and Frs3 during mouse development.  Development, 133, 663-673. PubMed

Nord A.S., Chang P.J., Conklin B.R., Cox A.V., Harper C.A., Hicks G.G., Huang C.C., Johns S.J., Kawamoto M., Liu S., Meng E.C., Morris J.H., Rossant J., Ruiz P., Skarnes W.C., Soriano P., Stanford W.L., Stryke D., von Melchner H., Wurst W., Yamamura K., Young S.G., Babbitt P.C., Ferrin T.E. (2006). The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Res., 34, D642-648. PubMed

Davy, A. and Soriano, P. (2005). Ephrin signaling in vivo: look both ways. Developmental Dyn., 232, 1-10. PubMed

Xu, X., Bringas Jr., P., Soriano, P. and Chai, Y. (2005). PDGFR-α signaling is critical for tooth cusp and palate morphogenesis. Developmental Dyn., 232, 75-84. PubMed

Austin CP, Battey JF, Bradley A, Bucan M, Capecchi M, Collins FS, Dove WF, Duyk G, Dymecki S, Eppig JT, Grieder FB, Heintz N, Hicks G, Insel TR, Joyner A, Koller BH, Lloyd KC, Magnuson T, Moore MW, Nagy A, Pollock JD, Roses AD, Sands AT, Seed B, Skarnes WC, Snoddy J, Soriano P, Stewart DJ, Stewart F, Stillman B, Varmus H, Varticovski L, Verma IM, Vogt TF, von Melchner H, Witkowski J, Woychik RP, Wurst W, Yancopoulos GD, Young SG, Zambrowicz B. (2004). The knockout mouse project. Nature Genetics, 36, 921-4. PubMed

Ding, H., Wu, X., Boström, H., Kim, I., Wong, N., Tsoi, B., O’Rourke, M., Koh, G.Y., Soriano, P., Betsholtz, C., Hart, T.C., Marazita, M.L., Field, L.L., Tam, P.P.L., and Nagy, A. (2004). A specific requirement of PDGF-C in palate formation and PDGFR-α signaling. Nature Genetics, 36, 1111-6. PubMed

Aubin, J., Davy, A. and Soriano, P. (2004). In vivo convergence of BMP and MAPK signaling pathways: impact of differential Smad1 phosphorylation on development and homeostasis. Genes Dev., 18, 1482-1494. PubMed

Skarnes, W.C., von Melchner, H., Wurst, W., Hicks, G., Nord, A.S., Cox, T., Young, S.G., Ruiz, P., Soriano, P., Tessier-Lavigne, M., Conklin, B.R., Stanford, W.L., and Rossant, J. (2004). A public gene trap resource for mouse functional genomics. Nature Genetics, 36, 543-544. PubMed

Chen, W.V., Delrow, J., Corrin, P.D., Frazier, J.P., and Soriano, P. (2004). Identification and Validation of PDGF transcriptional targets by microarray-coupled gene trap mutagenesis. Nature Genetics, 36, 304-312. PubMed

Davy, A., Aubin, J. and Soriano, P. (2004). Ephrin-B1 forward and reverse signaling are required during mouse development. Genes Dev., 18, 572-83. PubMed

Tallquist, M.D., French, W.J. and Soriano, P. (2003). Additive effects of PDGF receptor β signaling pathways in vascular smooth muscle cell development.  PLoS Biology, 1, 288-299. PubMed

Chen, W.V., and Soriano, P. (2003). Gene trap mutagenesis in embryonic stem cells. In Differentiation of Embryonic Stem Cells (P.M. Wassarman and G. M. Keller, eds.), Methods in Enzymology, 365, 367-386. PubMed

Awatramani, R., Soriano, P., Rodriguez, C., Mai, J.J. and Dymecki, S.M. (2003). Cryptic boundaries in roof plate and choroid plexus revealed by intersectional gene activation. Nature Genetics, 35, 70-75. PubMed

Hoch, R.V., and Soriano, P. (2003). PDGF roles in animal development. Development, 130, 4769-84. PubMed

Tallquist, M.D. and Soriano, P. (2003). Cell autonomous requirement for PDGFRalpha in populations of cranial and cardiac neural crest cells. Development. 130, 507-518. PubMed

Hamilton, T.G., Klinghoffer, R.A., Corrin, P.D., and Soriano, P. (2003). Evolutionary divergence of platelet-derived growth factor alpha receptor signaling mechanisms. Mol Cell Biol., 23, 4013-25. PubMed

Hildebrand, J.D. and Soriano, P. (2002). Overlapping and unique functions of CtBP1 and CtBP2 during mouse embryonic development. Mol. Cell. Biol., 22, 5296-307. PubMed

Klinghoffer, R. A., Hamilton, T. G., Hoch, R., and Soriano, P. (2002). An allelic series at the PDGFαR locus indicates unequal contributions of distinct signaling pathways during development. Developmental Cell, 2, 103-113. PubMed

Komada, M. and Soriano, P. (2002). βIV-Spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier. J. Cell Biol., 156, 337-348. PubMed

Nadeau, J.H., Balling, R., Barsch, G., Beier, D., Brown, S.D., Bucan, M., Camper, S., Carlson, G., Copeland, N., Eppig, J., Fletcher, C., Frankel, W.N., Ganten, D., Goldowitz, D., Goodnow, C., Guenet, J.L., Hicks, G., de Angelis, M.H., Jackson, I., Jacob, H.J., Jenkins, N., Johnson, D., Justice, M., Kay, S., Kingsley, D., Lehrach, H., Magnuson, T., Meisler, M., Poustka, A., Rinchik, E.M., Rossant, J., Russell, L.B., Schimenti, J., Shiroishi, T., Skarnes, W.C., Soriano, P., Stanford, W., Takahashi, J.S., Wurst, W., and Zimmer, A. (2001). Sequence interpretation. Functional annotation of mouse genome sequences. Science, 291, 1251-1255. PubMed

Klinghoffer, R.A., Mueting-Nelsen-P.F., Faerman, A, Shani, M. and Soriano, P. (2001). The two PDGFRs display conserved signaling in vivo despite divergent embryological functions. Molecular Cell, 7, 343-354. PubMed

Medico, E., Gambarotta, G., Gentile, A., Comoglio, P.M., and Soriano, P. (2001). Identification of HGF target genes by a novel genome-wide functional screening. Nature Biotech. 19, 579-582. PubMed

Awatramani, R., Soriano, P., Mai, J.J., and Dymecki, S. (2001). A FLP indicator mouse expressing alkaline phosphatase from the ROSA26 Locus. Nature Genetics, 29, 257-259. PubMed

Tallquist, M.D. and Soriano, P. (2000). Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic versus extra-embryonic gene function. Genesis, 26, 113-115. PubMed

Jiang, X., Rowitch, D.H., Soriano, P., McMahon, A.P., and Sucov, H.M. (2000). Fate of the mammalian cardiac neural crest. Development, 127, 1607-1616. PubMed

Chai, Y., Jiang, X., Ito, Y., Bringas, P., Han, J., Rowitch, D.H., Soriano, P., McMahon, A.P., and Sucov, H. (2000). Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development, 127, 1671-1679. PubMed

Klesert, T.R., Cho, D.H., Clark, J.I., Maylie, J., Adelman, J., Snider, L., Yuen, E.C., Soriano, P., and Tapscott, S.J. (2000). Mice deficient in Six5 develop cataracts: implications for myotonic dystrophy. Nature Genetics, 25, 105-109. PubMed

Li, X., Ponten, A., Aase, K., Karlsson, L., Abramsson, A., Uutela, M., Backström, G., Hellström, M., Boström, H., Li, H., Soriano, P., Betsholtz, C., Heldin, C-H., Alitalo, K., Östman, A. and Eriksson, U. (2000) PDGF-C is a new protease-activated ligand for the PDGF α-receptor. Nature Cell Biol., 2, 302-309. PubMed

Komada, M., McLean, D.J., Griswold, M.D., Russell, L.D., and Soriano, P. (2000). E-MAP-115, encoding a microtubule-associated protein, is a retinoic acid-inducible gene required for spermatogenesis. Genes Dev., 14, 1332-1342. PubMed

Tallquist, M.D., Weismann, K., Hellström, M., and Soriano, P. (2000). Early myotome specification regulates PDGFA expression and axial skeleton development. Development, 127, 5059-70. PubMed

Farley, F.W., Soriano, P., Steffen, L., and Dymecki, S.M. (2000). Widespread recombinase expression using FLPeR (Flipper) Mice. Genesis, 28, 106-110. PubMed

Tallquist, M.D., Klinghoffer, R.A., Heuchel, R., Mueting-Nelsen, P.F., Corrin, P.D., Heldin, C-H., Johnson, R.J., and Soriano, P. (2000). Retention of PDGFR β function in mice in the absence of phosphatidylinositol-3′ kinase and phospholipase C γ signaling pathways. Genes Dev., 14, 3179-90. PubMed

Soriano, P. (1999). Generalized lacZ expression with the ROSA26 Cre reporter strain. Nature Genetics, 21, 70-71. PubMed

Lanier, L.M., Gates, M., Witke, W., Menzies, A.S., Wehman, A.M., Macklis, J., Kwiatkowski, D., Soriano, P., and Gertler, F.B. (1999). Requirement of Mena in neurulation and commissure formation. Neuron 22, 313-325. PubMed

Wilde, A., Beattie, E.C., Lem, L., Riethof, D.A., Liu, S-H, Mobley, W.C., Soriano, P., and Brodsky, F.M. (1999). EGF receptor signaling stimulates Src kinase phosphorylation of Clathrin influencing Clathrin redistribution and EGF uptake. Cell 96, 677-687. PubMed

Klinghoffer, R.A., Sachsenmaier, C., Cooper, J.A., and Soriano, P. (1999). Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J. 18, 2459-71. PubMed

Komada, M. and Soriano, P. (1999). Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis. Genes Dev. 13, 1475-1485. PubMed

Ohlsson, R., Falck, P., Hellström, M., Lindahl, P., Bostrom, H., Franklin, G., Ahrlund-Richter, L., Pollard, J., Soriano, P., and Betsholtz, C. (1999). PDGF-B regulates the development of the labyrinthine layer of the mouse fetal placenta. Dev. Biol. 212, 124-136. PubMed

Heuchel, R., Berg, A., Tallquist, M., Ahlen, K., Reed, R.K., Rubin, K., Claesson-Welsh, L., Heldin, C.H., and Soriano, P. (1999). Platelet-derived growth factor beta receptor regulates interstitial fluid homeostasis through phosphatidylinositol-3´-kinase signaling. Proc. Natl. Acad. Sci. USA, 96, 11410-415. PubMed

Hildebrand, J.D., and Soriano, P. (1999). Shroom, a PDZ domain-containing actin-binding protein, is required for neural-tube morphogenesis in mice. Cell, 99, 485-497. PubMed

Andrews, A., Balciunaite, E., Leong, F.L., Tallquist, M., Soriano, P., Refojo, M. and Kazlauskas, A. (1999) Platelet-derived growth factor plays a key role in proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci 40, 2683-89. PubMed

Davy, A., Gale, N.W., Murray, E.W., Klinghoffer, R.A., Soriano, P., Feuerstein, C. and Robbins, S.M. (1999). Compartmentalized signaling by GPI-anchored Ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion. Genes Dev. 13, 3125-35. PubMed

Tallquist, M.D., Soriano, P., and Klinghoffer, R.A. (1999). Growth factor signaling pathways in vascular development. Oncogene, 18, 7917-32. PubMed

Cohen, N.R., Taylor, J.S.H., Scott, L.B., Guillery, R.W., Soriano, P., and Furley, A. (1998) Errors in corticospinal axon guidance in mice lacking the neural cell adhesion molecule L1. Current Biol., 8, 26-33. PubMed

Foley, K.P., McArthur, G.A., Queva, C., Hurlin, P.J., Soriano, P., and Eisenman, R.N. (1998). Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiation. EMBO J., 17, 774-785. PubMed

Crosby, J.R., Seifert, R.A., Soriano P., and Bowen-Pope, D.F. (1998). Chimaeric analysis reveals role of PDGF receptors in all muscle lineages. Nature Genetics 18, 385-388. PubMed

Fransen, E., D’Hooge, R., Van Camp, G., Verhoye, M., Sijbers, J., Reyniers, E., Soriano, P., Kamiguchi, H., Willemsen, R., Koekkoek, S.K.E., De Zeeuw, C.I., De Deyn, P.P., Van der Linden, A., Lemmon, V., Kooy, R.F. and Willems, P.J. (1998). L1 knockout mice show dilated ventricles, vermis hypoplasia and impaired exploration patterns. Hum. Mol. Genet. 6, 999_1009. PubMed

Lindahl, P., Hellström, M., Kalén, M., Karlsson, L., Pekny, M., Pekna, M., Soriano, P. and Betsholtz, C. (1998). Paracrine PDGF-B/PDGF-Rβ signaling controls mesangial cell development in kidney glomeruli. Development 125, 3313-22. PubMed

Gallagher, E., Howell, B.W., Soriano, P., Cooper, J.A., and Hawkes, R. (1998). Cerebellar abnormalities in the disabled (mdab1-1) mouse. J. Comp. Neurol. 402, 238-251. PubMed

Zambrowicz, B.P., Imamoto, A., Fiering, S., Herzenberg, L.A., Kerr, W.G., and Soriano, P. (1997). Disruption of overlapping transcripts in the ROSA b geo 26 gene trap strain leads to widespread expression of βgalactosidase in mouse embryos and hematopoietic cells. Proc. Natl. Acad. Sci. USA, 94, 3789-94. PubMed

Chan, V.W.F., Meng, F., Soriano, P., DeFranco, A.L., Lowell, C.A. (1997). Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity, 7, 69-81. PubMed

Soriano, P. (1997). The PDGF α Receptor is required for neural crest cell development and for normal patterning of the somites. Development, 124, 2691_2700. PubMed

Howell, B.W., Hawkes, R., Soriano, P., and Cooper, J.A. (1997). Neuronal position in the developing brain is regulated by mouse disabled-1. Nature, 389, 733-737. PubMed

Friedrich, G.A., Hildebrand, J.D., and Soriano, P. (1997). The secretory protein Sec8 is required for paraxial mesoderm formation in the mouse. Dev. Biol., 192, 364-374. PubMed

Lowell, C.A., and Soriano, P. (1996). Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories. Genes Dev., 10, 1845-1857. PubMed

Gertler, F.B., Niebuhr, K., Reinhard, M., Wehland, J., and Soriano, P. (1996). Mena, a relative of Vasp and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell, 87, 227-239. PubMed

Lowell, C.A., Niwa, M., Soriano, P., and Varmus, H.E. (1996). Deficiency of Hck and Src tyrosine kinases results in extreme levels of extramedullary hematopoiesis. Blood, 87, 1780-1792. PubMed

Soriano, P. (1995). Gene targeting in ES cells. Annual Review Neuro. 18, 1-18. PubMed

MacGregor, G.R., Zambrowicz, B.P., and Soriano, P. (1995). Tissue non-specific alkaline phosphatase is expressed in both embryonic and extra-embryonic lineages during mouse development but is not required for migration of mouse primordial germ cells. Development, 121, 1487-1496. PubMed

Thomas, S.M., Soriano, P., and Imamoto, A. (1995). Specific and redundant roles of Src and Fyn in organizing the cytoskeleton. Nature, 376, 267-271. PubMed

Guy, C.T., Muthuswamy, S.K., Cardiff, R.D., Soriano, P., and Muller, W.J. (1994). Activation of the c-Src tyrosine kinase is required for the induction of mammary tumors in transgenic mice. Genes Dev.,8, 23-32. PubMed

Imamoto, A., Soriano, P., and Stein, P.L. (1994). Genetics of signal transduction: tales from the mouse. Curr. Opin. Genet. Dev., 4, 40-46. PubMed

Kiefer, F., Anhauser, I., Soriano, P., Aguzzi, A., Courtneidge, S. A., and Wagner, E. F. (1994). Endothelial cell transformation by polyomavirus middle T antigen in mice lacking Src-related kinases. Current Biology,4, 100-109. PubMed

Lowell, C.A., Soriano, P., and Varmus, H. E. (1994). Functional overlap in the src-gene family: Inactivation of hck and fgr impairs natural immunity. Genes Dev., 8, 387-398. PubMed

Ignelzi Jr., M. A., Miller, D. R., Soriano, P., and Maness, P. F. (1994). Impaired neurite outgrowth of src minus neurons on the cell adhesion molecule L1. Neuron, 12, 873-884. PubMed

Soriano, P. (1994). Abnormal kidney development and hematological disorders in PDGF β receptor mutant mice. Genes Dev., 8, 1888-1896. PubMed

Stein, P.L., Vogel, H., and Soriano, P. (1994). Combined deficiencies of src, fyn, and yes tyrosine kinases in mutant mice. Genes Dev., 8, 1999-2007. PubMed

Chen, Z., Friedrich, G. A., and Soriano, P. (1994). Transcriptional Enhancer Factor-1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice. Genes Dev., 8, 2293_2301. PubMed

Beggs, H.E., Soriano, P., Maness, P.F. (1994). N-CAM-dependent neurite outgrowth is inhibited in neurons from Fyn- mice. J. Cell Biol., 127, 825-833. PubMed

Zhuang, Y., Soriano, P., and Weintraub, H. (1994). The helix-loop-helix gene E2A is required for B-Cell formation. Cell, 79, 875-884. PubMed

Boyce, B.F., Chen, H., Soriano, P., and Mundy, G.R. (1993) Histomorphometric and immunocytochemical studies of Src-related osteopetrosis. Bone, 14, 335-340. PubMed

Lowe, C., Yoneda, T., Boyce, B. F., Mundy, G. R., and Soriano, P. (1993). Osteopetrosis in src deficient mice is due to an autonomous defect of osteoclasts. Proc. Natl. Acad. Sci. USA, 90, 4485-89. PubMed

Thomas, J. E., Aguzzi, A., Soriano, P., Wagner, E. F., and Brugge, J. S. (1993). Induction of tumor formation and cell transformation by Polyoma middle T antigen in the absence of src. Oncogene, 8, 2521-29. PubMed

Imamoto, A., and Soriano, P. (1993). Disruption of the csk gene, encoding a negative regulator of src family kinases, leads to neural tube defects and embryonic lethality in mice. Cell, 73, 1117-1124. PubMed

Grompe, M., Al-Dhalimy, M., Finegold, M., Ou, C. N., Burlingame, T., Kennaway, N. G., and Soriano, P. (1993) Loss of fumarylacetoacetate hydrolase is responsible for the neonatal hepatic dysfunction phenotype of lethal albino mice. Genes Dev., 7, 2298_2307. PubMed

Friedrich, G., and Soriano, P. (1993). Insertional mutagenesis by retroviruses and promoter traps in embryonic stem cells. In Guide to Techniques in Mouse Development (P.M. Wassarman and M.L. DePamphilis, eds.), Methods in Enzymology 225, 681-701. PubMed

Stein, P. L., Lee, H., Rich, S., and Soriano, P. (1992). pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells. Cell 70, 741-750. PubMed

Boyce, B. F., Yoneda, T., Lowe, C., Soriano, P., and Mundy, G. R. (1992). Requirement of pp60c-src expression for osteoclasts to form ruffled borders and resorb bone. J Clin. Invest., 90, 1622-1627. PubMed

Giese, K. P., Martini, R., Lemke, , G., Soriano, P., and Schachner, M. (1992). Disruption of the P0 gene in mice leads to hypomyelination, abnormal expression of recognition molecules, and degeneration of myelin and axons. Cell, 71, 565-576. PubMed

Grant, S. G. N., O’Dell, T. J., Karl, K. A., Stein, P. L., Soriano, P., and Kandel, E. R. (1992). Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science 258, 1903-1910. PubMed

O’Dell, T.J., Grant, S.G.N., Karl, K., Soriano, P., and Kandel, E.R. (1992). Pharmacological and genetic approaches to the analysis of tyrosine kinase function in long term potentiation. Cold Spring Harbor Symp. Quant. Biol., 57, 517-526. PubMed

Soriano, P., Montgomery, C., Geske, R., and Bradley, A. (1991).Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64, 693-702. PubMed

Thomas, J., Soriano, P., and Brugge, J. S. (1991). Phosphorylation of c-src on tyrosine 527 by another protein tyrosine kinase. Science 254, 568-571. PubMed

Friedrich, G., and Soriano, P. (1991). Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 5, 1513-1523. PubMed

Soriano, P., Friedrich, G., and Lawinger, P. (1991). Promoter interactions in retroviral vectors introduced into fibroblasts and embryonic stem cells. J. Virol. 65, 2314-19. PubMed