Madhuri Kalathur, PhD
Madhuri is a Postdoctoral fellow and did her PhD in Life Sciences from the University of Lausanne, Switzerland. She is interested in understanding the mechanism of mutual PTEN and PREX2 regulation that appears to be involved in the activation of the PI3K and RAC1. Her primary research goal is to elucidate the structure of PREX2 along with its interacting partners PTEN and Rac1 using Cryo-EM and X-ray diffraction methods. Anticipating that these studies will provide a rationale for therapeutic targeting of PREX2 and further understanding of the structural basis of PREX2 activity.
Kyrie Pappas, PhD
Kyrie is a recent Ph.D. graduate of the Parsons laboratory. She received her B.S. from Michigan Technological University in Biochemistry and Molecular Biology and then obtained her Ph.D. from Columbia University in Pharmacology and Molecular Signaling. Her research in the laboratory has focused on three main projects: Project 1: p53 maintains baseline expression of multiple other tumor suppressor genes through cis-regulatory elements in enhancers and promoters. Project 2: Molecular mechanisms of transcriptional repression of PTEN in breast cancer. Project 3: Identifying novel genetic alterations in triple-negative breast cancer using next-generation sequencing approaches.
Supported by: Ruth L. Kirschstein National Research Service Award (NRSA) Individual Predoctoral Fellowship (NIH F31, 2014-2016)
Ilias research focuses on elucidating the complex biologic and biochemical effects of components of the phosphoinositide 3-kinase (PI3K) signaling pathway with an emphasis on breast cancer. He has developed a series of in vivo and in vitro models which he uses to understand how cancer cells evade the effects of PI3K-targeted therapies and identify vulnerabilities that can be translated into new treatment strategies in the clinic.