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Perhaps the most fundamental process in biology is that by which one cell becomes two. Our research focuses on two related aspects of the biology that controls the integrity of the genome

1. We study the control of the cell division cycle, and the signaling pathways (checkpoints) that respond to chromosomal damage and prevent cell cycle progression until that damage is repaired.

2. We are investigating how determinants of chromosome structure regulate chromosome segregation and DNA repair, with an emphasis on events that occur during DNA replication.