Publications

Lavin Y, Kobayashi S, Leader A, Amir ED, Elefant N, Bigenwald C, Remark R, Sweeney R, Becker CD, Levine JH, Meinhof K, Chow A, Kim-Schulze S, Wolf A, Medaglia C, Li H, Rytlewski JA, Emerson RO, Solovyov A, Greenbaum BD, Sanders C, Vignali M, Beasley MB, Flores R, Gnjatic S, Pe’er D, Rahman A, Amit I, Merad M. (2017) Innate Immune Landscape in Early Lung Adenocarcinoma by Paired Single-Cell Analyses. Cell 169(4): 750-765.e17 doi: 10.1016/j.cell.2017.04.014. Link

Chudnovskiy A, Mortha A, Kana V, Kennard A, Ramirez JD, Rahman A, Remark R, Mogno I, Ng R, Gnjatic S, Amir ED, Solovyov A, Greenbaum B, Clemente J, Faith J, Belkaid Y, Grigg ME, Merad M. (2016) Host-Protozoan Interactions Protect from Mucosal Infections through Activation of the Inflammasome. Cell 167(2): 444-456.e14 doi: 10.1016/j.cell.2016.08.076, Link

Salmon H, Idoyaga J, Rahman A, Leboeuf M, Remark R, Jordan S, Casanova-Acebes M, Khudoynazarova M, Agudo J, Tung N, Chakarov S, Rivera C, Hogstad B, Bosenberg M, Hashimoto D, Gnjatic S, Bhardwaj N, Palucka AK, Brown BD, Brody J, Ginhoux F, Merad M. (2016) Expansion and Activation of CD103+ Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition. Immunity 44(4): 924-938 doi: 10.1016/j.immuni.2016.03.012. PDF

Price JG, Idoyaga J, Merad M. (2016) Reply to: “Subverting misconceptions about radiation therapy”. Nature Immunology 17: 345-346 doi:10.1038/ni.3376. PDF

Lavin Y, Mortha A, Rahman A, Merad M. (2015) Regulation of macrophage development and function in peripheral tissues. Nature Reviews Immunology 15: 731-744 doi:10.1038/nri3920. PDF

Upadhyay R, Hammerich L, Peng P, Brown B, Merad M, Brody JD. (2015) Lymphoma: immune evasion strategies. Cancers 7(2): 736-762 doi:10.3390/cancers7020736. PDF

Price JG, Idoyaga J, Salmon H, Hogstad B, Bigarella CL, Ghaffari S, Leboeuf M, Merad M. (2015) CDKN1A regulates Langerhans cell survival and promotes Treg cell generation upon exposure to ionizing irradiation. Nature Immunology 16: 1060-1068 doi:10.1038/ni.3270. PDF

Merad M, Salmon H. (2015) Cancer: A dendritic-cell brake on antitumor immunity. Nature 523(7560): 294-295 doi: 10.1038/523294a. PDF

Hoeffel G, Chen J, Lavin Y, Low D, Almeida FF, See P, Beaudin AE, Lum J, Low I, Forsberg EC, Poidinger M, Zolezzi F, Larbi A, Ng LG, Chan JK, Greter M, Becher B, Samokhvalov IM, Merad M, Ginhoux F. (2015) C-myb(+) erythro-myeloid progenitor-derived fetal monocytes give rise to adult tissue-resident macrophages. Immunity 2015 42(4): 665-678 doi:10.1016/j.immuni.2015.03.011. Link

Naik S, Bouladoux N, Linehan JL, Han SJ, Harrison OJ, Wilhelm C, Conlan S, Himmelfarb S, Byrd AL, Deming C, Quinones M, Brenchley JM, Kong HH, Tussiwand R, Murphy KM, Merad M, Segre JA, Belkaid Y. (2015) Commensal-dendritic-cell interaction specifies a unique protective skin immune signature. Nature 520(7545): 104-108 doi: 10.1038/nature14052. Link

Berres ML, Merad M, Allen CE. Progress in understanding the pathogenesis of Langerhans cell histiocytosis: back to Histiocytosis X?. (2015) British Journal of Haematology 169(1): 3-13 doi: 10.1111/bjh.13247PDF

Remark R, Becker C, Gomez JE, Damotte D, Dieu-Nosjean MC, Sautès-Fridman C, Fridman WH, Powell CA, Altorki NK, Merad M, Gnjatic S. (2015) The non-small cell lung cancer immune contexture. A major determinant of tumor characteristics and patient outcome. American Journal of Respiratory and Critical Care Medicine 2015 Feb; 191(4): 377-390 doi: 10.1164/rccm.201409-1671PPPDF

Berres ML, Lim KP, Peters T, Price J, Takizawa H, Salmon H, Idoyaga J, Ruzo A, Lupo PJ, Hicks MJ, Shih A, Simko SJ, Abhyankar H, Chakraborty R, Leboeuf M, Beltrão M, Lira SA, Heym KM, Clausen BE, Bigley V, Collin M, Manz MG, McClain K, Merad M, Allen CE. (2015) BRAF-V600E expression in precursor versus differentiated dendritic cells defines clinically distinct LCH risk groups. The Journal of Experimental Medicine 212(2): 281 doi: 10.1084/jem.2013097701202015c. Link

Zitvogel L, Galluzzi L, Viaud S, Vétizou M, Daillère R, Merad M, Kroemer G. (2015) Cancer and the gut microbiota: an unexpected link. Science Translational Medicine 7(271): 271ps1 doi: 10.1126/scitranslmed.3010473PDF

Lavin Y, Winter D, Blecher-Gonen R, David E, Keren-Shaul H, Merad M, Jung S, Amit I. (2014) Tissue-resident macrophage enhancer landscapes are shaped by the local microenvironment. Cell 159(6): 1312-1326 doi:10.1016/j.cell.2014.11.018. Link

Mielcarek M, Kirkorian AY, Hackman RC, Price J, Storer BE, Wood BL, Leboeuf M, Bogunovic M, Storb R, Inamoto Y, Flowers ME, Martin PJ, Collin M, Merad M. (2014) Langerhans cell homeostasis and turnover after nonmyeloablative and myeloablative allogeneic hematopoietic cell transplantation. Transplantation 98(5): 563-568 doi: 10.1097/TP.0000000000000097PDF

Muller PA, Koscsó B, Rajani GM, Stevanovic K, Berres ML, Hashimoto D, Mortha A, Leboeuf M, Li XM, Mucida D, Stanley ER, Dahan S, Margolis KG, Gershon MD, Merad M, Bogunovic M. (2014) Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility. Cell 158(2): 300-313 doi:10.1016/j.cell.2014.04.050. Link

Mortha A, Chudnovskiy A, Hashimoto D, Bogunovic M, Spencer SP, Belkaid Y, Merad M. (2014) Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis. Science 343(6178): 1249288 doi: 10.1126/science.1249288PDF

Agudo J, Ruzo A, Tung N, Salmon H, Leboeuf M, Hashimoto D, Becker C, Garrett-Sinha LA, Baccarini A, Merad M, Brown BD. (2014) The miR-126-VEGFR2 axis controls the innate response to pathogen-associated nucleic acids. Nature Immunology 15(1): 54-62 doi: 10.1038/ni.2767. Link

Lavin Y, Merad M. (2013) Macrophages: gatekeepers of tissue integrity. Cancer Immunology Research 1(4): 201-209 doi: 10.1158/2326-6066.CIR-13-0117. Link

Hamard PJ, Barthelery N, Hogstad B, Mungamuri SK, Tonnessen CA, Carvajal LA, Senturk E, Gillespie V, Aaronson SA, Merad M, Manfredi JJ. (2013) The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo. Genes & Development 27: 1868-1885 doi: 10.1101/gad.224386.113. Link

Hashimoto D, Chow A, Noizat C, Teo P, Beasley MB, Leboeuf M, Becker CD, See P, Price J, Lucas D, Greter M, Mortha A, Boyer SW, Forsberg EC, Tanaka M, van Rooijen N, García-Sastre A, Stanley ER, Ginhoux F, Frenette PS, Merad M. (2013) Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity 38(4): 792-804 doi: 10.1016/j.immuni.2013.04.004. Link

Chow A, Huggins M, Ahmed J, Hashimoto D, Lucas D, Kunisaki Y, Pinho S, Leboeuf M, Noizat C, van Rooijen N, Tanaka M, Zhao ZJ, Bergman A, Merad M, Frenette PS. (2013) CD169⁺ macrophages provide a niche promoting erythropoiesis under homeostasis and stress. Nature Medicine 19(4): 429-436 doi:10.1038/nm.3057. Link

Berres ML, Allen CE, Merad M. (2013) Pathological consequence of misguided dendritic cell differentiation in histiocytic diseases. Advances in Immunology 120: 127-161 doi: 10.1016/B978-0-12-417028-5.00005-3PDF

Greter M, Merad M. (2013) Regulation of microglia development and homeostasis. Glia 61(1): 121-127 doi: 10.1002/glia.22408PDF

Greter M, Helft J, Chow M, Hashimoto D, Mortha A, Agudo-Cantero J, Bogunovic M, Gautier EL, Miller K, Leboeuf M, Lu G, Aloman C, Brown BD, Pollard JW, Xiong H, Randolph GJ, Chipuk JE, Frenette PS, Merad M. (2012) GM-CSF controls nonlymphoid tissue dendritic cell homeostasis but is dispensable for the differentiation of inflammatory dendritic cells. Nature Immunology 36(6): 1031-1046 doi: 10.1016/j.immuni.2012.03.027. Link

Bogunovic M, Mortha A, Muller PA, Merad M. (2012) Mononuclear phagocyte diversity in the intestine. Immunology Research 54(1-3): 37-49 doi: 10.1007/s12026-012-8323-5PDF

Ginhoux F, Ng LG, Merad M. (2012) Understanding the murine cutaneous dendritic cell network to improve intradermal vaccination strategies. Current Topics in Microbiology and Immunology 351: 1-24 doi: 10.1007/82_2010_115. Link

Chow A, Brown BD, Merad M. (2011) Studying the mononuclear phagocyte system in the molecular age. Nature Review Immunology 11: 788-798 doi:10.1038/nri3087PDF

Hashimoto D, Miller K, Merad M. (2011) Dendritic cell and macrophage heterogeneity in vivo. Immunity 35(3): 323-335 doi: 10.1016/j.immuni.2011.09.007PDF

Ginhoux F, Merad M. (2011) Microglia arise from extra-embryonic yolk sac primitive progenitors. Medi Sci (Paris) 27(8-9): 719-724 doi: 10.1051/medsci/2011278013. Link

Hashimoto D, Chow A, Greter M, Saenger Y, Kwan WH, Leboeuf M, Ginhoux F, Ochando JC, Kunisaki Y, van Rooijen N, Liu C, Teshima T, Heeger PS, Stanley ER, Frenette PS, Merad M. (2011) Pretransplant CSF-1 therapy expands recipient macrophages and ameliorates GVHD after allogeneic hematopoietic cell transplantation. The Journal of Experimental Medicine 208(5): 1069-1082 doi: 10.1084/jem.20101709. Link

Hashimoto D, Merad M. (2011) Harnessing dendritic cells to improve allogeneic hematopoietic cell transplantation outcome. Seminars in Immunology 23(1): 50-57 doi: 10.1016/j.smim.2011.01.005PDF

Ginhoux F, Greter M, Leboeuf M, Nandi S, See P, Gokhan S, Mehler MF, Conway SJ, Ng LG, Stanley ER, Samokhvalov IM, Merad M. (2010) Fate mapping analysis reveals that adult microglia derive from primitive macrophages. Science 330(6005): 841-845 doi: 10.1126/science.1194637. Link

Ginhoux F, Merad M. (2010) Ontogeny and homeostasis of Langerhans cells. Immunology & Cell Biology 88(4): 387-392 doi: 10.1038/icb.2010.38PDF

Helft J, Ginhoux F, Bogunovic M, Merad M. (2010) Origin and functional heterogeneity of non-lymphoid tissue dendritic cells in mice. Immunology Reviews 234(1): 55-75 doi: 10.1111/j.0105-2896.2009.00885.xPDF

Helft J, Merad M. (2010) Isolation of cutaneous dendritic cells. Methods in Molecular Biology 595: 231-233 doi: 10.1007/978-1-60761-421-0_15Link

Ginhoux F, Liu K, Helft K, Bogunovic M, Greter M, Hashimoto D, Price J, Yin N, Bromberg J, Lira SA, Stanley ER, Nussenzewig M, Merad M. (2009) The origin and development of nonlymphoid tissue CD103+ DCs. The Journal of Experimental Medicine 206(13): 3115-3130 doi: 10.1084/jem.20091756. Link

Bogunovic M, Ginhoux F, Helft J, Shang L, Hashimoto D, Greter M, Liu K, Jakubzick C, Ingersoll MA, Leboeuf M, Stanley ER, Nussenzweig M, Lira SA, Randolph GJ, Merad M. (2009) Origin of the lamina propria dendritic cell network. Immunity 31(3): 513-525. Link

Ginhoux F, Collin MP, Bogunovic M, Abel M, Leboeuf M, Helft J, Ochando J, Kissenpfennig A, Malissen B, Grisotto M, Snoeck H, Randolph G, Merad M. (2007) Blood-derived dermal Langerin+ dendritic cells survey the skin in the steady state. The Journal of Experimental Medicine 204(13): 3133-3146 doi: 10.1084/jem.20071733. Link

Collin MP, Bogunovic M, Merad M. (2007) DC homeostasis in hematopoietic stem cell transplantation. Cytotherapy 9(6): 521-531 doi: 10.1080/14653240701507314. Link

Bogunovic M, Ginhoux F, Wagers A, Loubeau M, Isola LM, Lubrano L, Najfeld V, Phelps RG, Grosskreutz C, Scigliano E, Frenette PS, Merad M. (2006) Identification of a radio-resistant and cycling dermal dendritic cell population in mice and men. The Journal of Experimental Medicine 203(12): 2627-2638 doi: 10.1084/jem.20060667. Link