Harnessing The Tumor Immune Microenvironment:
Dendritic cells (DC) and macrophages are prominent components of the tumor microenvironment and can induce anti-tumor immunity by virtue of their function as antigen presenting cells (APC). These cells also promote tumor growth due to the release of potent soluble mediators that regulate tumor cell proliferation or survival.
One of the primary goals of the laboratory is to understand the contribution of mononuclear phagocytes to tumor homeostasis, tumor immunity, and tumor response to conventional or targeted therapies.
Using mainly endogenous tumor models, and when necessary, tumor grafts, we explore, with live imaging, the dynamic interactions between tumor cells and phagocytes, as well as the mechanisms that control the induction of potent and therapeutic antitumor immunity in the tumor microenvironment.