Experimental Psychopathology Laboratory

Experimental Psychopathology Laboratory

Welcome to the home page of Dr. David Kimhy’s Experimental Psychopathology Laboratory. We conduct laboratory and “real-world” studies of cognitive, affective, and behavioral processes and their link to psychopathology in people with Serious Mental Illness (SMI), in particular individuals with schizophrenia and at-risk for psychosis. Our work centers on two primary areas:

 

  1. The use of translational approaches to elucidate the mechanisms of development and recovery from psychopathology.
  2. The development and dissemination of cognitive and behavioral interventions to improve cognitive, affective, and social functioning.

 

 

 

 

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Contact Us

Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place
Box 1230
New York, NY 10029
Phone: 212-585-4656
david.kimhy@mssm.edu

Director

 

David Kimhy, PhD is an Associate Professor, the Director of the Experimental Psychopathology Laboratory, and the Program Leader for New Interventions in Schizophrenia at the Department of Psychiatry at the Icahn School of Medicine at Mount Sinai. Additionally, Dr. Kimhy serves as a Research Scientist at The Mental Illness Research, Education and Clinical Center (MIRECC) at the James J. Peters VA Medical Center in The Bronx, NY.

Dr. Kimhy completed a 3-year NIMH-funded post-doctoral fellowship in schizophrenia research at the Department of Psychiatry at Columbia University. During this period he also served as a Beck Institute Scholar at the Beck Institute for Cognitive Behavior Therapy. Following his post-doctoral training, he joined the Department of Psychiatry at Columbia University and The New York State Psychiatric Institute were he served as faculty for 12 years before joining Mount Sinai and MIRECC.  Dr. Kimhy’s research funding include grants from the National Institute of Mental Health (NIMH), The Brain & Behavior Research Foundation (formerly NARSAD), as well as institutional funding.

 

 

 

 

 

 

 

 

 

David Kimhy, PhD
Associate Professor, Psychiatry
david.kimhy@mssm.edu 

Team

Luz H. Ospina, PhD
Project Director

Katie Beck-Felts, BA
Research Coordinator

Chloe Ifrah, Doctoral Candidate
Clinical and Cognitive Rater

Shaina Shagalow, Doctoral Candidate
Clinical and Cognitive Rater

Vanessa Castillo, MS
Exercise Physiologist

Training

 

Dr. Kimhy is currently accepting applications for postdoctoral fellowship training in research and treatment of Serious Mental Illness (SMI) starting in Summer/Fall 2020. Fellowship positions are offered via a partnership between the New York MIRECC and the Department of Psychiatry, Icahn School of Medicine at Mount Sinai. The primary appointment is at the James J. Peters VA Medical Center in the Bronx, with a secondary appointment at the Icahn School of Medicine at Mount Sinai in Manhattan. For more information about the fellowship training and admission process please visit the New York MIRECC fellowship’s web page. Primary focus areas of training include research and treatment of schizophrenia and suicide risk. For inquiries about training opportunities with Dr. Kimhy, please contact him at david.kimhy@mssm.edu

 

The James J. Peters VA Medical Center, Bronx, NY

 

 

 

 

Studies

 

Improving Cognition via Exercise in schizophrenia (ICE) – An NIMH R01-funded, multi-site, single-blind, randomized clinical trial examining the efficacy of exercise to improve neurocognition, daily functioning, and biomarkers of cognitive change in individuals with schizophrenia (PIs: David Kimhy & T. Scott Stroup;  ClinicalTrials.gov Identifier: NCT03270098).

SUicide Reduction In Schizophrenia via Exercise (SUnRISE) – An NIMH-funded R01 supplement for a  multi-site, single-blind, randomized clinical trial examining the efficacy of exercise to reduce suicide risk in individuals with schizophrenia (PIs: David Kimhy & T. Scott Stroup).

Phenotyping Risk Of Psychiatric HospiTalization (PROPHeT) –  A pilot study examining the use of data collected via mobile phones to digitally phenotype and predict risk of psychiatric hospitalization in individuals with severe psychopathology (PI: David Kimhy).

Dissemination of CBT for Psychosis in Doctoral Psychology and Psychiatry Training Programs in the USA and Canada  – A survey of training directors of doctoral psychology and psychiatry training programs in the USA and Canada examining the dissemination of Cognitive Behavioral Therapy for Psychosis (CBTp) in training programs (PI: David Kimhy).

Optimizing and Personalizing Interventions for Schizophrenia Across the Lifespan (OPAL) – An NIMH P50-funded single-blind, randomized clinical trial examining the efficacy of using mHealth-based (smartphone) technologies to optimize treatment for individuals with first-episode psychosis (PIs Project III: T. Scott Stroup & David Kimhy).

Hippocampal Inflammation as a Pathophysiology of Psychosis – An NIMH-funded study examining the role of hyppocampal inflammation’s contribution to the development of psychotic symptoms and its link to the gut-brain-axis, in particular the gut microbiome (PI: Dolores Malaspina).

Using the RDoC to Understand Thought Disorder: A Linguistic Corpus-Based Approach – An NIMH-funded study utilizing automated natural language processing to assess thought disorder in individuals with recent-onset psychosis and healthy controls (PI: Cheryl Corcoran).

 

 

 

Funding

 

Current

Improving Cognition via Exercise (ICE) in Schizophrenia – NIMH R01 MH110623 (2017-2021); Principal Investigators: David Kimhy & T. Scott Stroup.

SUicide Reduction In Schizophrenia via Exercise (SUnRISE) – NIMH R01 MH110623–03S1; Principal Investigators: David Kimhy & T. Scott Stroup. 

Optimizing and Personalizing Interventions for Schizophrenia Across the LifeSpan (OPAL) – NIMH P50 MH115843 (2018-2022); Principal Investigators (Project III): T. Scott Stroup & David Kimhy.

Thought Disorder and Social Cognition in Clinical Risk States for Schizophrenia – NIMH R01 MH107558 (2017-2021); Principal Investigator: Cheryl Corcoran.

Using the RDoC to Understand Thought Disorder: A Linguistic Corpus-Based Approach – NIMH R01 MH11533 (2018-2021); Principal Investigator: Cheryl Corcoran.

Hippocampal Inflammation as a Pathophysiology for Psychosis – NIMH R01 MH110418 (2017-2022); Principal Investigator: Dolores Malaspina.

 

Previous (Selected)

The Influence of Aerobic Exercise on Cognitive Functioning in Schizophrenia – NIMH R21 MH096132 (2012-2015); Principal Investigator: David Kimhy.

Double Blind, Two Dose, Cross-Over Clinical Trial of the Positive Allosteric Modulator at the Alpha7 Nicotinic Cholinergic Receptor AVL-3288 in Schizophrenia Patients – NIMH U01 MH094247 (2016-2017); Principal Investigator: Jeffrey Lieberman.

Psychosis in Schizophrenia: Mechanisms of Recovery – NIMH K23 MH077653 (2007-2013); Principal Investigator: David Kimhy.

The Influence of Arousal on Paranoia in Schizophrenia: An Experience Sampling Study – NARSAD Young Investigator Award  (2009-2011); Principal Investigator: David Kimhy.

Treatment Units for Research on Neurocognition and Schizophrenia (TURNS)- NIMH N01 MH041003 (2004-2007); Principal Investigator: Stephen Marder.

The Feasibility of Assessing Ambulatory Autonomic Regulation in Schizophrenia – VivoMetrics, Inc. (2005-2006); Principal Investigator: David Kimhy.

 

Publications

2019

Kogan S, Ospina LH, Mittal VA, Kimhy D: The Impact of Inflammation on Neurocognition and Psychosis Risk: A Critical Review. European Archives of Psychiatry and Clinical Neuroscience, In Press. PMID:31620871.

Kraus MS, Gold JM, Barch DM, Walker TM, Chun CA, Buchanan RW, Csernansky JG, Goff DC, Green MF, Jarskog LF, Javitt DC, Kimhy D, Lieberman JA, McEvoy JP, Mesholam-Gately RI, Seidman LJ, Ball MP, Kern RS, McMahon RP, Robinson J, Marder SR, Keefe RSE. The Characteristics of Cognitive Neuroscience Tests in a Schizophrenia Cognition Clinical Trial: Psychometric Properties and Correlations with Standard Measures. Schizophrenia Research: Cognition, In Press.

Vakhrusheva J, Khan S, Chang R, Hansen M, Ayanruoh L, Gross JJ, Kimhy D. Lexical Analysis of Emotional Responses to “Real-World” Experiences in Individuals with Schizophrenia. Schizophrenia Research, In Press.

Malaspina D, Walsh-Messinger J, Brunner A, Rahman N, Corcoran C, Kimhy D, Goetz RR, Goldman SB. Features of Schizophrenia Following Premorbid Eating Disorders. Psychiatry Research 2019. PMID: 31254876.

Yee C, Strauss G, Allen D, Haase C, Kimhy D, Mittal V. Trait Emotional Experience in Individuals with Schizophrenia and Youth at Clinical High-Risk for Psychosis. BJPsych Open, In Press. PMID: 31500685.

2016 - 2018

Shoval A, Armstrong HF, Vakhrusheva J, Ballon JS, Bartels MN, Kimhy D. The Impact of Hypomania on Aerobic Capacity and Cardiopulmonary Functioning – A Case Report. Frontiers in Psychiatry 2018; 9:729. PMID: 30622490.

Kogan S, Ospina LH, Kimhy D. Inflammation in Individuals with Schizophrenia – Implications for Neurocognition and Daily Function. Brain, Behavior, and Immunity 2018; 74:296-9. PMID: 30218782.

Benavides C, Brucato G, Kimhy D. Self-Esteem and Symptoms in Individuals at Clinical High Risk for Psychosis. The Journal of Nervous and Mental Disease 2018; 206(6):433-8. PMID: 29781891.

Redman SL, Corcoran CM, Kimhy D, Malaspina D. Effects of Early Trauma on Psychosis Development in Clinical High-Risk Individuals and Stability of Trauma Assessment Across Studies: A Review. Archives of Psychology. 2017;1(3). PMID: 29400347.

Brucato G, Masucci MD, Arndt LY, Ben-David S, Colibazzi T, Corcoran CM, Crumbley AH, Crump FM, Gill KE, Kimhy D, Lister A. Baseline Demographics, Clinical Features and Predictors of Conversion Among 200 Individuals in a Longitudinal Prospective Psychosis-Risk Cohort. Psychological Medicine 2017; 47(11):1923-35. PMID: 28249639.

Kimhy D, Wall M, Hansen MC, Vakhrusheva J, Choi J, Delespaul P, Tarrier N, Sloan RP, Malaspina D: Autonomic Regulation and Auditory Hallucinations in Schizophrenia: An Experience Sampling Study. Schizophrenia Bulletin 2017; 43:754-763. PMID: 28177507.

Vakhrusheva J, Marino B, Stroup TS, Kimhy D. Aerobic Exercise in People with Schizophrenia: Neural and Neurocognitive Benefits. Current Behavioral Neuroscience Reports 2016; 3(2):165-75. PMID: 27766192.

Kimhy D. Cognitive-Behavioral Therapy for Olfactory Hallucinations and Associated Delusions: A Case Report. American Journal of Psychotherapy 2016; 70(1):117-23. PMID: 27052609.

Kimhy D, Gill KE, Brucato G, Vakhrusheva J, Arndt L, Gross JJ, Girgis RR: The Impact of Emotion Awareness and Regulation on Social Functioning in Individuals at Clinical High-Risk for Psychosis. Psychological Medicine 2016; 46:2907-2918. PMID: 27050714.

Armstrong HF, Bartels MN, Paslavski O, Cain D, Shoval HA, Ballon JS, Khan S, Sloan RP, Kimhy D. The Impact of Aerobic Exercise Training on Cardiopulmonary Functioning in Individuals with Schizophrenia. Schizophrenia Research 2016; 173(1-2):116. PMID: 26976498.

Kimhy D, Lauriola V, Bartels MN, Armstrong HF, Vakhrusheva J, Ballon JS, Sloan RP. Aerobic Exercise for Cognitive Deficits in Schizophrenia – The Impact of Frequency, Duration, and Fidelity with Target Training Intensity. Schizophrenia Research 2016. 172(1-3):213-5. PMID: 26852401.

Mourik K, Decrescenzo P, Brucato G, Gill KE, Arndt L, Kimhy D, Keilp JG, Girgis RR. Various Neurocognitive Deficits and Conversion Risk in Individuals at Clinical High Risk for Psychosis. Early Intervention in Psychiatry 2017; 11(3):250-4. PMID: 26663764.

Kimhy D, Khan S, Ayanruoh L, Chang RW, Hansen MC, Lister A, Ballon JS, Vakhrusheva J, Armstrong HF, Bartels MN, Sloan RP: Use of Active-Play Video Games to Enhance Aerobic Fitness in Schizophrenia: Feasibility, Safety and Adherence. Psychiatric Services 2016; 67:24-243. PMID: 26423100.

Crowley OV, Kimhy D, McKinley PS, Burg MM, Schwartz JE, Lachman ME, Tun PA, Ryff CD, Seeman TE, Sloan RP. Vagal Recovery from Cognitive Challenge Moderates Age-related Deficits in Executive Functioning. Research on Aging 2016; 38(4):504-25. PMID: 26303063

2013 - 2015

Blum LH, Vakhrusheva J, Saperstein A, Khan S, Chang RW, Hansen MC, Zemon V, Kimhy D. Depressed Mood in Individuals with Schizophrenia: A Comparison of Retrospective and Real-Time Measures. Psychiatry Research 2015; 227(2-3):318-23. PMID: 25895490.

Kimhy D, Vakhrusheva J, Bartels MN, Armstrong HF, Ballon JS, Khan S, Chang RW, Hansen MC, Ayanruoh L, Lister A, Castrén E, Smith EE, Sloan RP: The Impact of Aerobic Exercise on Brain-Derived Neurotrophic Factor and Neurocognition in Individuals with Schizophrenia: A Single-Blind, Randomized Clinical Trial. Schizophrenia Bulletin 2015; 41:859-868. PMID: 25805886.

Kimhy D, Vakhrusheva J, Bartels MN, Armstrong HF, Ballon JS, Khan S, Chang RW, Hansen MC, Ayanruoh L, Smith EE, Sloan RP: Aerobic Fitness and Body Mass Index in Individuals with Schizophrenia: Implications for Neurocognitive and Daily Functioning. Psychiatry Research 2014; 220:784-791. PMID: 25219618

Kimhy D, Vakhrusheva J, Liu Y, Wang Y: Use of Mobile Assessment Technologies in Inpatient Psychiatric Settings. Asian Journal of Psychiatry 2014; 10:90–95. PMID: 25042959.

Kimhy D, Vakhrusheva J, Khan S, Chang RW, Hansen MC, Ballon JS, Malaspina D, Gross JJ. Emotional Granularity and Social Functioning in Individuals with Schizophrenia: An Experience Sampling Study. Journal of Psychiatric Research 2014; 53:141-148. PMID: 24561000.

Kimhy D, Tarrier N, Essock S, Malaspina D, Cabaniss D, Beck AT: Cognitive Behavioral Therapy for Psychosis: Dissemination and Training Practices in the United States. Psychosis: Psychological, Social and Integrative Approaches 2013; 5:296-305. PMID: 24187582.

Haglund M, Cabaniss D, Kimhy D, Corcoran CM. A Case Report of Cognitive Behavioural Therapy for Social Anxiety in an Ultra‐High Risk Patient. Early Intervention in Psychiatry 2014; 8(2):176-180. PMID: 23734668.

Kimhy D, Jobson‐Ahmed L, Ben‐David S, Ramadhar L, Malaspina D, Corcoran CM. Cognitive Insight in Individuals at Clinical High Risk for Psychosis. Early Intervention in Psychiatry 2014; 8(2):130-137. PMID: 23343417.

Devylder JE, Ben-David S, Schobel SA, Kimhy D, Malaspina D, Corcoran CM. Temporal Association of Stress Sensitivity and Symptoms in Individuals at Clinical High Risk for Psychosis. Psychological medicine 2013 Feb; 43(2):259-68. PMID: 22651857.

Kimhy D, Crowley OV, McKinley PS, Burg MM, Lachman ME, Tun PA, Ryff CD, Seeman TE, Sloan RP. The Association of Cardiac Vagal Control and Executive Functioning – Findings from the MIDUS Study. Journal of Psychiatric Research 2013; 47(5):628-35. PMID: 23434176.

DeVylder JE, Ben‐David S, Kimhy D, Corcoran CM. Attributional Style Among Youth at Clinical Risk for Psychosis. Early Intervention in Psychiatry 2013; 7(1):84-8. PMID: 22390315.

2010 - 2012

Kimhy D, Vakhrusheva J, Jobson-Ahmed L, Tarrier N, Malaspina D, Gross JJ: Emotion Awareness and Regulation in Individuals with Schizophrenia: Implications for Social Functioning. Psychiatry Research 2012; 200:193-201. PMID: 22749227.

Kimhy D, Myin-Germeys I, Palmier-Claus J, Swendsen J: Mobile Assessment Guide for Research in Schizophrenia and Severe Mental Disorders. Schizophrenia Bulletin 2012; 38:386-395. PMID: 22287280.

Javitt DC, Buchanan RW, Keefe RS, Kern R, McMahon RP, Green MF, Lieberman J, Goff DC, Csernansky JG, McEvoy JP, Jarskog F, Seidman LJ, Gold JM, Kimhy D, Nolan KS, Barch DS, Ball MP, Robinson J, Marder SR. Effect of the Neuroprotective Peptide Davunetide (AL-108) on Cognition and Functional Capacity in Schizophrenia. Schizophrenia Research 2012; 136(1-3):25-31. PMID: 22169248.

Buchanan RW, Keefe RS, Lieberman JA, Barch DM, Csernansky JG, Goff DC, Gold JM, Green MF, Jarskog LF, Javitt DC, Kimhy D, Kraus MS, McEvoy JP, Mesholam-Gately RI, Seidman LJ, Ball MP, McMahon RP, Kern RS, Robinson J, Marder SR. A Randomized Clinical Trial of MK-0777 for the Treatment of Cognitive Impairments in People with Schizophrenia. Biological Psychiatry 2011 69(5):442-449. PMID: 21145041.

Antonius D, Kimhy D, Harkavy-Friedman J, Crystal S, Goetz R, Malaspina D. Paternal Age Related Schizophrenia and Cardiac Autonomic Regulation Profiles. Schizophrenia Research 2011; 127(1-3):273. PMID: 21036543.

Corcoran CM, Kimhy D, Parrilla-Escobar MA, Cressman VL, Stanford AD, Thompson J, David SB, Crumbley A, Schobel S, Moore H, Malaspina D. The Relationship of Social Function to Depressive and Negative Symptoms in Individuals at Clinical High Risk for Psychosis. Psychological Medicine 2011; 41(2):251-261. PMID: 20444306.

Kimhy D, Delespaul P, Ahn H, Cai S, Shikhman M, Lieberman JA, Malaspina D, Sloan RP: Concurrent Measurement of “Real-World” Stress and Arousal in Individuals with Psychosis: Assessing the Feasibility and Validity of a Novel Methodology. Schizophrenia Bulletin 2010; 36:1131-1139. PMID: 19429846.

For a complete list of publications, please visit:

In the Media

Hearing Voices Others Can’t – How a Growing Movement Fights Mental Health Stigma 

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How Secret Spying Programs Affect the Clinically Paranoid

Exercise May Improve Memory, Thinking in People With Schizophrenia

Can You Diagnose a Manic Episode on Twitter?

Does Aerobic Exercise Help Improve Cognition in People with Schizophrenia?

Dr. David Kimhy
Icahn School of Medicine at Mount Sinai
One Gustave L. Levy Place
Box 1230
New York, NY 10029

Phone: 212-585-4656
Email: david.kimhy@mssm.edu