Our Small Molecule Ligands

Selective, Small-Molecule Inhibitors of Protein Methyltransferases

Inhibitors listed below are available. Please contact Dr. Jian Jin (jian.jin@mssm.edu)

Our small molecule inhibitors:

UNC0638 for G9a/GLP (PMID: 21743462); UNC0642 for G9a/GLP (PMID: 24102134);

MS012 for GLP (PMID: 28135087);

UNC1999 for EZH2/EZH1 (PMIDs: 23614352 and 25395428);

UNC0379, MS2177 and MS453 for SETD8 (PMIDs: 25032507 and 27804297);

MS023 for type I PRMTs (PMID: 26598975); SGC707 for PRMT3 (PMID: 25728001);

MS049 for CARM1 and PRMT6 (PMID: 27584694);

HUK1-121 for CARM1 (PMID: 28042453)