Selected Publications:
2015
The Use of Herpes Simplex Virus in Ex Vivo Slice Culture.
Friedman AK, Han MH.
Current Protocols in Neuroscience. 2015 Jul 1;72:4.36.1-7.
Excitatory transmission at thalamo-striatal synapses mediates susceptibility to social stress.
Christoffel DJ, Golden SA, Walsh JJ, Guise KG, Heshmati M, Friedman AK, Dey A, Smith M, Rebusi N, Pfau M, Ables JL, Aleyasin H, Khibnik LA, Hodes GE, Ben-Dor GA, Deisseroth K, Shapiro ML, Malenka RC, Ibanez-Tallon I, Han MH, Russo SJ.
Nature Neuroscience. 2015 Jul;18(7):962-4. Epub 2015 Jun 1.
Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression.
Bagot RC, Parise EM, Peña CJ, Zhang HX, Maze I, Chaudhury D, Persaud B, Cachope R, Bolaños-Guzmán CA, Cheer J, Deisseroth K, Han MH, Nestler EJ.
Nature Communications. 2015 May 8;6:7062.
2014
Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors.
Heller EA, Cates HM, Pena CJ, Sun H, Shao N, Feng J, Golden SA, Herman JP, Walsh JJ, Mazei-Robison M, Ferguson D, Knight S, Gerber MA, Nievera C, Han MH, Russo SJ, Tamminga CS, Neve RL, Shen L, Zhang HS, Zhang F, Nestler EJ.
Nature Neuroscience, 2014.
Loss of BDNF Signaling in D1R-Expressing NAc Neurons Enhances Morphine Reward by Reducing GABA Inhibition.
Koo JW, Lobo MK, Chaudhury D, Labonté B, Friedman A, Heller E, Peña CJ, Han MH, Nestler EJ.
Neuropsychopharmacology, 2014 Oct;39(11):2646-53.
Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling.
Li B, Jie W, Huang L, Wei P, Li S, Luo Z, Friedman AK, Meredith AL, Han MH, Zhu XH, Gao TM.
Nature Neuroscience, 2014 Aug;17(8):1055-63.
The heterogeneity of ventral tegmental area neurons: Projection functions in a mood-related context.
Walsh JJ, Han MH.
Neuroscience, 2014 Jun 12; 282C:101-108.
Enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience.
Friedman AK, Walsh JJ, Juarez B, Ku SM, Chaudhury D, Wang J, Li X, Dietz DM, Pan N, Vialou VF, Neve RL, Yue Z, Han MH.
Science, 2014 Apr 18;344(6181):313-9.
G9a influences neuronal subtype specification in striatum.
Maze I, Chaudhury D, Dietz DM, Von Schimmelmann M, Kennedy PJ, Lobo MK, Sillivan SE, Miller ML, Bagot RC, Sun H, Turecki G, Neve RL, Hurd YL, Shen L, Han MH, Schaefer A, Nestler EJ.
Nature Neuroscience, 2014 Apr;17(4):533-9.
Stress and CRF gate neural activation of BDNF in the mesolimibic reward pathway.
Walsh JJ, Friedman AK, Sun H, Heller EA, Ku SM, Juarez B, Burnham VL, Mazei-Robison M, Ferguson D, Golden SA, Koo JW, Chaudhury D, Christoffel DJ, Pomeranz L, Friedman J, Russo SJ, Nestler EJ, Han MH.
Nature Neuroscience, 2014 Jan;17(1):27-9.
2013
DeltaFosB induction in striatal medium spiny neuron subtypes in response to chronic pharmacological, emotional, and optogenetic stimuli.
Lobo MK, Zaman S, Damez-Werno D, Koo JW, Bagot R, DiNieri J, Nugent A, Finkel E, Chaudhury D, Chandra R, Riberio E, Rabkin J, Mouzon E, Cachope R, Cheer J, Han MH, Dietz D, Self D, Hurd Y, Vialou V, Nestler EJ.
Journal of Neuroscience 2013 Nov 20;33(47):18381-95.
Optogenetic inhibition of D1R containing nucleus accumbens neurons alters cocaine-mediated regulation of Tiam1.
Chandra R, Lenz JD, Gancarz AM, Chaudhury D, Schroeder GL, Han MH, Cheer J, Dietz DM, Lobo MK.
Frontiers in Molecular Neuroscience 2013 May 24;6:13.
Class I HDAC inhibition blocks cocaine-induced plasticity by targeted changes in histone methylation.
Kennedy PJ, Feng J, Robison AJ, Maze I, Badimon A, Mouzon E, Chaudhury D, Damez-Werno DM, Haggarty SJ, Han MH, Bassel-Duby R, Olson EN, Nestler EJ.
Nature Neuroscience 2013 Apr;16(4):434-40.
Rapid regulation of depression-like behaviors by control of midbrain dopamine neurons.
Chaudhury D, Walsh JJ, Friedman AK, Juarez B, Ku SM, Koo JW, Ferguson D, Tsai HC, Pomeranz L, Christoffel D, Nectow AR, Ekstrand M, Domingos A, Mazie-Robison M, Mouzon E, Lobo MK, Neve RL, Friedman JM, Russo SJ, Deisseroth K, Nestler EJ, Han MH.
Nature 2013 Jan 24;493(7433):532-6. [Chaudhury and Walsh contributed equally]
2012
Neurobiology of resilience.
Russo SJ, Murrough JW, Han MH, Charney DS, Nestler EJ.
Nature Neuroscience 2012 Nov;15(11):1475-84.
BDNF is a negative modulator of morphine action.
Koo JW, Mazei-Robison MS, Chaudhury D, Juarez B, LaPlant Q, Ferguson D, Feng J, Sun H, Scobie KN, Damez-Werno D, Crumiller M, Ohnishi YN, Ohnishi YH, Mouzon E, Dietz DM, Lobo MK, Neve RL, Russo SJ, Han MH, Nestler EJ.
Science 2012 Oct 5;338(6103):124-8.
HDAC2 regulates atypical antipsychotic responses through the modulation of mGlu2 promoter activity.
Kurita M, Holloway T, García-Bea A, Kozlenkov A, Friedman AK, Moreno JL, Heshmati M, Golden SA, Kennedy PJ, Takahashi N, Dietz DM, Mocci G, Gabilondo AM, Hanks A, Umali A, Callado LF, Gallitano AL, Neve RL, Shen L, Buxbaum JD, Han MH, Nestler EJ, Meana JJ, Russo SJ, González-Maeso J.
Nature Neuroscience 2012 Sep;15(9):1245-54.
Virogenetic and optogenetic mechanisms to define potential therapeutic targets in psychiatric disorders.
Han MH, Friedman AK.
Neuropharmacology 2012 Jan;62(1):89-100.
2011
Role for mTOR signaling and neuronal activity in morphine-induced adaptations in ventral tegmental area dopamine neurons.
Mazei-Robison MS, Koo JW, Friedman AK, Lansink CS, Robison AJ, Vinish M, Krishnan V, Kim S, Siuta MA, Galli MA, Niswender KD, Appasani R, Horvath MC, Neve RL, Worley PF, Snyder SH, Hurd YL, Cheer JF, Han MH, Russo SJ, Nestler EJ.
Neuron 2011 Dec 22;72(6):977-90.
Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the ClockΔ19 mouse model of mania.
Coque L, Mukherjee S, Cao JL, Spencer S, Marvin M, Falcon E, Sidor MM, Birnbaum SG, Graham A, Neve RL, Gordon E, Ozburn AR, Goldberg MS, Han MH, Cooper DC, McClung CA.
Neuropsychopharmacology 2011 Jun;36(7):1478-88.
Reinforcement-related regulation of AMPA glutamate receptor subunits in the ventral tegmental area enhances motivation for cocaine.
Choi KH, Edwards S, Graham DL, Larson EB, Whisler KN, Simmons D, Friedman AK, Walsh JJ, Rahman Z, Monteggia LM, Eisch AJ, Neve RL, Nestler EJ, Han MH, Self DW.
Journal of Neuroscience 2011 May 25;31(21):7927-37.
IkappaB kinase regulates social defeat stress-induced synaptic and behavioral plasticity.
Christoffel DJ, Golden SA, Dumitriu D, Robison AJ, Janssen WG, Ahn HF, Krishnan V, Reyes CM, Han MH, Ables JL, Eisch AJ, Dietz DM, Ferguson D, Neve RL, Greeengard P, Kim Y, Morrison JH, Russo SJ.
Journal of Neuroscience 2011 Jan 5;31(1):314-21.
2010
Mesolimbic dopamine neurons in the brain reward circuit mediate susceptibility to social defeat and antidepressant action.
Cao JL, Covington III HE, Friedman AK, Wilkinson MB, Walsh JJ, Cooper DC, Nestler EJ, Han MH.
Journal of Neuroscience 2010 Dec 8;30(49):16453-8.
Cell type specific loss of BDNF signaling mimics optogenetic control of cocaine reward.
Lobo MK, Covington III HE, Chaudhury D, Friedman AK, Sun HS, Damez-Werno D, Dietz D, Zaman S, Koo JW, Kennedy PJ, Mouzon E, Mogri M, Neve RL, Deisseroth K, Han MH, Nestler EJ.
Science 2010 Oct 15;330(6002):385-90.
Essential role of the cAMP-CREB pathway in opiate-induced homeostatic adaptations of locus coeruleus neurons.
Cao JL, Vialou VF, Lobo MK, Robison AJ, Neve RL, Cooper DC, Nestler EJ, Han MH.
Proceedings of the National Academy of Sciences USA 2010 Sep 28;107(39):17011-6.
Extracellular signal-regulated kinase-2 within the ventral tegmental area regulates responses to stress.
Iñiguez SD, Vialou V, Warren BL, Cao JL, Alcantara LF, Davis LC, Manojlovic Z, Neve RL, Russo SJ, Han MH, Nestler EJ, Bolaños-Guzmán CA.
Journal of Neuroscience 2010 Jun 2;30(22):7652-63.
Brain region specific actions of RGS4 oppose morphine reward and dependence but promote analgesia.
Han MH, Renthal W, Ring RH, Rahman Z, Psifogeorgou K, Howland D, Birnbaum S, Young K, Neve R, Gomes I, Devi LA, Nestler EJ, Zachariou V.
Biological Psychiatry 2010 Apr 15;67(8):761-9.