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The Giannarelli Laboratory uses cutting-edge technologies and innovative Systems Biology approaches to dissect the role of innate and adaptive immunity   in atherosclerotic cardiovascular disease. Despite optimal use of traditional therapeutic approach to atherosclerotic cardiovascular disease (CVD) morbidity and mortality due to myocardial infarction (MI) and stroke remain high and continue to rise globally. Inflammation and immunity are key processes in the pathogenesis of atherosclerosis—and promising targets for new therapies to treat cardiovascular disease.