Research Assistant Professor
shashank.tripathi@mssm.edu

 

 

 

 

 

Research Interests
My work involves development of systems based approaches to study virus-host interactions, specially Influenza A viruses. For this I am using genome wide CRISPR libraries in conjunction with global proteome and transcriptome analysis. I am also investigating broad spectrum cellular innate immune mechanisms against important human viral pathogens such as Influenza, Dengue, Herpes, and HIV. I am also looking at Influenza A virus life cycle events using reporter viruses and live imaging.

 

Notable Publications
Shashank Tripathi, Vinod Balasubramaniam, Julia A. Brown, Ignacio Mena, Alesha Grant et al, Adolfo García-Sastre* A novel Zika virus mouse model reveals strain specific differences in the virus pathogenesis and host inflammatory immune response. PLoS pathogens 13 (3), e1006258

Susana V. Bardina, Paul Bunduc, Shashank Tripathi, James Duehr, Justin J. Frere, et al, Adolfo García-Sastre*, Florian Krammer*, Jean K. Lim*. Enhancement of Zika virus pathogenesis by pre-existing anti-flavivirus immunity. Science 356 (6334), 175-180

Grant A, Ponia SS, Tripathi S et al, García-Sastre A*. Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling. Cell Host & Microbe. 2016; 19(6):882-90.

Tripathi S, Garcia-Sastre A*. Antiviral innate immunity through the lens of systems biology. Virus Research. 2016; 218;10-7

Tripathi S, Pohl MO, Zhou Y, Rodriguez-Frandsen A et al, König R*, Stertz S*, García-Sastre A*, Chanda SK*. Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding. Cell Host & Microbe. 2015; 18(6); 723-35