Postdoctoral Fellow
giorgi.metreveli@mssm.edu

Here we proposed an OMICS approach to identify key early genes/networks involved in influenza virus pathogenesis. This is achieved by modeling global host responses during influenza virus infection in a mouse model in collaboration with the Modeling Core and the OMICs Cores (Genomics, Proteomics and Metabolomics).

Research Interests
Influenza A virus is an important human pathogen that causes respiratory disease of different grades of severity according to the specific virus strain and to host susceptibility. Our main hypothesis is that host genes and networks involved in viral replication and in early host responses regulate disease outcome and represent targets for therapeutic intervention. We have assembled interrelated research projects: Project 1 investigates interactions of influenza viruses in vitro. My work focuses on Project 2, which studies the interactions of influenza viruses with host factors and networks in vivo in a mouse model. The aim is to characterize the impact of influenza A virus infection on the mouse lung at the transcriptome, proteome, and metabolome levels, by investigating the early global host responses associated with lethal, severe, and moderate virus infections. We use three clinically relevant strains of influenza A virus that differ in virulence, allowing for comparison of the host responses and interactions associated with different ranges of disease severity.

Notable Publications
Kuss-Duerkop SK, Wang J, Mena I, White K, Metreveli G, Sakthivel R, Mata MA, Muñoz-Moreno R, Chen X, Krammer F, Diamond MS, Chen ZJ, García-Sastre A, Fontoura BMA. Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication. PLoS Pathog. 2017 Sep 27;13(9).

Rialdi A, Campisi L, Zhao N, Lagda AC, Pietzsch C, Ho JSY, Martinez-Gil L, Fenouil R, Chen X, Edwards M, Metreveli G, Jordan S, Peralta Z, Munoz-Fontela C, Bouvier N, Merad M, Jin J, Weirauch M, Heinz S, Benner C, van Bakel H, Basler C, García-Sastre A, Bukreyev A, Marazzi I. Topoisomerase 1 inhibition suppresses inflammatory genes and protects from death by inflammation. Science. 2016 May 27;352(6289).

Heaton NS, Moshkina N, Fenouil R, Gardner TJ, Aguirre S, Shah PS, Zhao N, Manganaro L, Hultquist JF, Noel J, Sachs D, Hamilton J, Leon PE, Chawdury A, Tripathi S, Melegari C, Campisi L, Hai R, Metreveli G, Gamarnik AV, García-Sastre A, Greenbaum B, Simon V, Fernandez-Sesma A, Krogan NJ, Mulder LCF, van Bakel H, Tortorella D, Taunton J, Palese P, Marazzi I. Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection. Immunity. 2016 Jan 19;44(1):46-58.

Metreveli G, Gao Q, Mena I, Schmolke M, Berg M, Albrecht RA, García-Sastre A. The origin of the PB1 segment of swine influenza A virus subtype H1N2 determines viral pathogenicity in mice. Virus Res. 2014 Aug 8;188:97-102.