Foss-Feig Laboratory

Principal Investigator

About the Lab

Here at the Foss-Feig Lab, our research combines clinical assessments with brain-based methods, including EEG and MRI, to examine sensory and perceptual functioning in autism spectrum disorder (ASD). We also study the relation between ASD and other neurodevelopmental disorders, including schizophrenia and psychosis prodrome, as well as monogenic disorders with a prominent ASD phenotype.

The Foss-Feig Lab is part of the Seaver Autism Center for Research and Treatment at the Icahn School of Medicine at Mount Sinai. The Seaver Autism Center is a fully integrated, translational research center that leads progressive studies and provides personalized care to individuals with autism and related rare disorders. As a team, we are dedicated to discovering the biological causes of autism and developing breakthrough treatments.

Learn more about the Seaver Autism Center’s translational research approach.

Our Research

Using multimodal neuroimaging (EEG, MRI), psychophysical testing, eye tracking, and targeted clinical assessments, our research investigates sensory and perceptual processing as they differ between autism spectrum disorder (ASD) and typical development. We also examine the convergence and divergence between ASD and other neurodevelopmental disorders, including schizophrenia, as well as relations between experimental effects and specific patterns of clinical symptoms within the broad ASD population and among individuals exhibiting known genetic mutations that contribute to an ASD phenotype.

Our work addresses the following central questions:

Mechanisms of sensory and perceptual processing alterations in ASD

Question 1: Mechanisms of sensory and perceptual processing alterations in ASD

Sensory processing difficulties affect up to 90% of individuals with ASD. In fact, many families report that, on a day-to-day basis, they are among the most impairing parts of autism. And yet, sensory symptoms are diverse: different modalities (sight, hearing, touch) may be affected or unaffected, and individuals with ASD may be over-sensitive, under-sensitive, or have significant sensory cravings. From basic science, much is known about how sensory systems are organized in the brain and about what brain pathways, neurotransmitters, and interactions between populations of brain cells affect sensory functioning. This body of knowledge allows us to ask questions and uncover the brain-basis of sensory symptoms in ASD. Sensory systems are also among the first to develop in the brain and lay the foundation upon which more complex brain functions are built. In that sense, sensory processing differences may not only be important symptoms to understand in their own right, but may also give us clues to how social, communication, and behavioral differences in ASD develop.

In the lab, we ask several questions about sensory functioning in ASD. How are visual and auditory systems affected? Can we detect differences in the brain with EEG and/or with MRI that can give us clues about how, where, and when breakdowns in sensory processing occur? Is there something about the timing of how sensory input is processed that makes perception more difficult for individuals with ASD? How do sensory symptoms interact and integrate information? Can we probe differences in core brain-related mechanisms and circuitry using sensory stimuli and well-validated experimental approaches? Why do some individuals with ASD have unique visual processing strengths? How do sensory processing differences relate to other core symptoms in ASD? Can sensory symptoms be changed with treatment, and can we measure it

Overlap between ASD and schizophrenia

Question 2: Overlap between ASD and schizophrenia

Autism and schizophrenia were once considered the same disorder. We now understand that there are many differences between the two and most people with ASD do not have schizophrenia or psychosis. However, research has repeatedly shown that there are genes and brain differences that ASD and schizophrenia have in common. Many symptoms, such as social difficulties and sensory processing differences, trouble both people with ASD and people with schizophrenia. Moreover, a small but important subset of children and adults with ASD will show psychosis symptoms. Clinicians will sometimes wonder whether these individuals may have both ASD and schizophrenia or psychosis at the same time, and right now there is still little research on the topic.

This line of research asks several questions. How are brain functioning and sensory processing alike or different in those diagnosed with ASD versus those diagnosed with schizophrenia? Are there alterations in brain pathways and neurochemical interactions that ASD and schizophrenia have in common? Are children with ASD at higher than average risk for developing psychosis? If so, can we identify particular symptom patterns or differences in brain functioning that might help us predict which kids with ASD are at higher risk? Do those children with ASD where psychosis questions are raised actually progress to having a true psychotic illness? Can our concept of symptoms in ASD benefit from thinking about positive and negative symptoms like those in schizophrenia clinical service and research do?

Genetics-first approach to understanding mechanisms and developing biomarkers for ASD

Question 3: Genetics-first approach to understanding mechanisms and developing biomarkers for ASD

In the past decade, researchers have made large advances in understanding genes that contribute to autism. We now know of many specific genetic alterations (deletions, mutations, etc) that can confer high risk for ASD in affected individuals. Many of the genes that cause autism affect particular brain pathways, and basic science has told us much about the specific aspects of neurotransmitter, synapse, and cell structure and function that are directly impacted by these genetic alterations. Individuals sharing the same genetic alterations tend to have symptoms in common, making them a less heterogeneous group than we typically see in research and clinical work with individuals with ASD where the genetic origin is unknown. The Seaver Autism Center for Research and Treatment has an international reputation for its work in rare genetic syndromes associated with ASD, including Phelan McDermid syndrome, FOXP1 syndrome, and Fragile X syndrome. Our colleagues at Seaver are also conducting several clinical trials in these syndromes, which offers us the unique opportunity to explore how different interventions affect measurable aspects of brain functioning and behavior.

In this line of research, we collaborate with colleagues at Seaver to explore several research avenues. First, how is brain functioning and behavior different in individuals with genetic disorders? How is sensory functioning impacted, and how do social and attentional symptoms present? Second, how do differences in brain functioning in those with genetic syndromes compare to those in individuals with ASD with unknown cause (“idiopathic ASD”)? Are there groups of individuals with idiopathic ASD whose behavior and brain functioning looks similar to that associated with a specific genetic disorder? If so, might this give us clues into neural alterations that are affecting a broader portion of individuals with ASD, even when we don’t know the specific cause? Third, can we develop biomarkers for ASD starting in genetic syndromes? Are there brain-based alterations that are reliable across time and individuals and that can easily be measured regardless of a child’s functioning level or the research or clinical setting? Do these markers help us know which children will benefit from a specific treatment? When we do treat children, do these biomarkers show change? Can this work inform biomarkers and treatment approaches for ASD more broadly?