Seeking people who are:
- 15-35 years old
- English-Speaking
- Having psychotic-like experiences such as unusual thoughts, suspiciousness, or perceptual disturbances that have bothered them or interfered with their functioning.
This study involves:
- Interviews and games: Computer games, pen-and-paper tasks, and audio-recorded interview
- Brain Imaging (MRI): At rest, and while listening to stories or looking at faces
- Brain Wave Testing: EEG while listening to sounds
- Blood Draw
Cheryl Corcoran, MD, is an Associate Professor of Psychiatry and the Program Leader in Psychosis Risk at the Icahn School of Medicine at Mount Sinai.
Recent Publications
Corcoran CM, Cecchi GA. Using language processing and speech analysis for the identification of psychosis and other disorders. Biological Psychiatry Cognitive Neuroscience and Neuroimaging. 2020 Aug;5(8): 770-779. Using Language Processing and Speech Analysis for the Identification of Psychosis and other Disorders.
Corcoran CM, Mittal VA, Bearden CE, E Gur R, Hitczenko K, Bilgrami Z, Savic A, Cecchi GA, Wolff P. Language as a biomarker for psychosis: A natural language processing approach. Schizophrenia Research 2020 Jun 1: S0920-9964(20)30247-4. Language as a biomarker for psychosis: A natural language processing approach.
Corcoran CM, Cecchi GA. Computational approaches to behavior analysis in psychiatry. Neuropsychopharmacology 2018 Jan; 43(1); 225-226. Computational Approaches to Behavior Analysis in Psychiatry.
Anglin DM, Ereshefsky S, Klaunig MJ, Bridgwater MA, Niendam TA, Ellman LM, DeVylder J, Thayer G, Bolden K, Musket CW, Grattan RE, Lincoln SH, Schiffman J, Lipner E, Bachman P, Corcoran CM, Mota NB, van der Ven E.Am J Psychiatry. 2021 Jul;178(7):599-610. doi: 10.1176/appi.ajp.2020.20071091. Epub 2021 May 3.PMID: 33934608. From Womb to Neighborhood: A Racial Analysis of Social Determinants of Psychosis in the United States.
DeLuca JS, Rakhshan Rouhakhtar P, Klaunig MJ, Akouri-Shan L, Jay SY, Todd TL, Sarac C, Andorko ND, Herrera SN, Dobbs MF, Bilgrami ZR, Kline E, Brodsky A, Jespersen R, Landa Y, Corcoran C, Schiffman J. Psychol Serv. 2022;19(Suppl 1):120-138. doi: 10.1037/ser0000585. Epub 2022 Mar 14.PMID: 35286123. Psychosis-like experiences and resilience: A systematic and critical review of the literature.
Ruiz B, Ceccolini CJ, Shah BB, Crump F, Girgis RR, Brucato G, Yang LH, Corcoran CM. Early Interv Psychiatry. 2022 Jan;16(1):34-41. doi: 10.1111/eip.13126. Epub 2021 Feb 4.PMID: 33543593. Stigma and Coping Experiences in Latinx individuals at clinical high-risk for psychosis.
DeLuca JS, Yang LH, Lucksted AA, Yanos PT, DeVylder J, Anglin DM, Landa Y, Corcoran CM.Schizophr Bull. 2021 Oct 21;47(6):1512-1514. doi: 10.1093/schbul/sbab098.PMID: 34401924 No abstract available. Reducing Stigma Among Youth at Risk for Psychosis
Corcoran CM, Mittal VA, Woods SW.JAMA Psychiatry. 2021 Aug 1;78(8):821-822. doi: 10.1001/jamapsychiatry.2021.0838.PMID: 33978689. Attenuated Psychosis Syndrome Should Be Moved to the Main Section in DSM-5 TR.
Corcoran CM, Carrillo F, Fernandez-Slezak D, Bedi G, Klim C, Javitt DC, Bearden CE, Cecchi GA. Prediction of psychosis across protocols and risk cohorts using automated language analysis. World Psychiatry 2018.
Bedi G, Carrillo F, Cecchi G, Fernandez-Slezak D, Sigman M, Mota NB, Ribeiro S, Javitt DC, Copelli M, Corcoran CM. Automated analysis of free speech predicts psychosis onset in high-risk youths. NPJ Schizophrenia 2015 Aug 26; 1:15030.
Stanislawski ER, Bilgrami ZR, Sarac C, Garg S, Heisig S, Cecchi GA, Agurto C, Corcoran CM. Negative symptoms and speech pauses in youths at clinical high risk for psychosis. NPJ Schizophr. 2021 Jan 22;7(1):3. doi: 10.1038/s41537-020-00132-1.PMID: 33483485
Bilgrami ZR, Sarac C, Srivastava A, Herrera SN, Azis M, Haas SS, Shaik RB, Parvaz MA, Mittal VA, Cecchi G, Corcoran CM. Construct validity for computational linguistic metrics in individuals at clinical risk for psychosis: Associations with clinical ratings. Schizophr Res. 2022 Jul;245:90-96. doi: 10.1016/j.schres.2022.01.019. Epub 2022 Jan 29.PMID: 35094918
Haas SS, Doucet GE, Garg S, Herrera SN, Sarac C, Bilgrami ZR, Shaik RB, Corcoran CM. Linking language features to clinical symptoms and multimodal imaging in individuals at clinical high risk for psychosis. European Psychiatry 2020 Aug 11; 63(1):e72.
Agurto C, Pietrowica M, Norel R, Eyigoz EK, Stanislawsk E, Cecchi G, Corcoran C. Analyzing acoustic and prosodic fluctuations in free speech to predict psychosis onset in high-risk youths. IEEE Engineering in Medicine and Biology Society (EMBC) 2020 Aug; INSPEC Accession number 19964141; doi 10.1109/EMBC44109.2020.9176841.
Argolo F, Magnavita G, Mota NB, Ziebold C, Mabunda D, Pan PM, Zugman A, Gadelha A, Corcoran C, Bressan RA. Lowering costs for large-scale screening in psychosis: A systematic review and meta-analysis of performance and value of information for speech-based psychiatric evaluation. Brazilian Journal of Psychiatry, Epub April 17 2020
Pietrowicz, M., Agurto, C., Norel, R., Eyigoz, E., Cecchi, G., Bilgrami, Z.R., Corcoran, C. (2019) A New Approach for Automating Analysis of Responses on Verbal Fluency Tests from Subjects At-Risk for Schizophrenia. Proc. Interspeech 2019, 3028-3032, DOI: 10.21437/Interspeech.2019-2987.
Corcoran CM, Carrillo F, Fernández-Slezak D, Bedi G, Klim C, Javitt DC, Bearden CE, Cecchi GA. (2018). Prediction of psychosis across protocols and risk cohorts using automated language analysis. World Psychiatry, 17(1):67-75.
Redman SL, Corcoran CM, Kimhy D, Malaspina D. (2017). Effects of early trauma on psychosis development in clinical high-risk individuals and stability of trauma assessment across studies: a review. Arch Psychol (Chic.).
Crump FM, Arndt L, Grivel M, Horga G, Corcoran CM, Brucato G, Girgis RR. (2017). Attenuated first-rank symptoms and conversion to psychosis in a clinical high-risk cohort. Early Interv Psychiatry.
Colibazzi T, Yang Z, Horga G, Chao-Gan Y, Corcoran CM, Klahr K, Brucato G, Girgis R, Abi-Dargham A, Milham MP, Peterson BS. (2017). Aberrant temporal connectivity in persons at clinical high risk for psychosis. Biol Psychiatry Cogn Neurosci Neuroimaging, 2(8):696-705.
Corcoran, CM & Cecchi, GA. (2017). Computational approaches to behavior analysis in psychiatry. Neuropsychopharmacology, 43(1): 225-226.
Corcoran CM, Stoops A, Lee M, Martinez A, Sehatpour P, Dias EC, Javitt DC. (2017). Developmental trajectory of mismatch negativity and visual event-related potentials in healthy controls: implications for neurodevelopmental vs. neurodegenerative models of schizophrenia. Schizophr Res, 191:101-108.
Corcoran, CM. (2017). Taking care of the careers: support for families of persons with early psychosis. World Psychiatry, 16(3):267-268.
Vadhan NP, Corcoran CM, Bedi G, Keilp JG, Haney M. (2017). Acute effects of smoked marijuana in marijuana smokers at clinical high-risk for psychosis: A preliminary study. Psychiatry Res., 257:372-374.
Poe SL, Brucato G, Bruno N, Arndt LY, Ben-David S, Gill KE, Colibazzi T, Kantrowitz JT, Corcoran CM, Girgis RR. (2017). Sleep disturbances in individuals at clinical high risk for psychosis. Psychiatry Res., 249:240-243.
Media
News:
(English)
Dr. Corcoran was named an Exemplary Psychiatrist by the National Alliance on Mental Illness: https://www.nami.org/Press-Media/Press-Releases/2022/NAMICon-2022-Virtual-Event-Honors-Mental-Health-Leaders
Exemplary Psychiatrist Awards: Honors psychiatrists who have made exceptional contributions to improve the lives of people with mental health conditions.
Ten Medical and Scientific Breakthroughs of 2021 at Mount Sinai –– Dr. Corcoran’s Study on Speech Changes as Predictors of Schizophrenia Risk listed 2nd! : https://www.mountsinai.org/about/newsroom/2021/ten-medical-and-scientific-breakthroughs-of-twentyone-at-mount-sinai.
Dr. Cecchi and Dr. Corcoran mentioned in the New York Times for their research in Alzheimer’s and Speech Prediction: https://www.nytimes.com/2021/02/01/health/alzheimers-prediction-speech.html
Speech analysis software predicted psychosis in at-risk patients with up to 83 percent accuracy: https://www.sciencedaily.com/releases/2018/01/180122104013.htm
Can an Algorithm Predict Schizophrenia? https://www.healthline.com/health-news/can-an-algorithm-predict-schizophrenia
The Sound of Your Voice May Diagnose Disease: https://www.scientificamerican.com/article/the-sound-of-your-voice-may-diagnose-disease/
Computers Can Predict Schizophrenia Based on How a Person Talks: https://www.theatlantic.com/technology/archive/2015/08/speech-analysis-schizophrenia-algorithm/402265/
Can you diagnose disease from the sound of a voice? https://www.statnews.com/2016/06/29/speech-diagnosis-technology/
Warning signs from a troubled mind: What parents should do http://www.cnn.com/2011/HEALTH/01/14/mental.health.loughner/index.html
(Spanish)
Se peude diagnosticar la psicosis mediante la forma de hablar: https://elmedicointeractivo.com/se-puede-diagnosticar-la-psicosis-mediante-la-forma-de-hablar/
Un análisis de habla predice la psicosis en pacientes en riesgo con un 80% de precisión: https://www.infosalus.com/asistencia/noticia-analisis-habla-predice-psicosis-pacientes-riesgo-80-precision-20180123074442.html
¿Cómo identificar problemas mentales en los adolescentes?: https://lamenteesmaravillosa.com/como-identificar-problemas-mentales-en-adolescentes/
Inteligencia artificial para predecir el desarrollo de psicosis: https://www.businessinsider.es/inteligencia-artificial-predecir-desarrollo-psicosis-189012
Este Algoritmo te Puede Decir Si Una Persona es Esquizofrénica: https://pijamasurf.com/2015/09/este-algoritmo-te-puede-decir-si-una-persona-es-esquizofrenica/
(Italian)
Psicosi. L’analisi automatizzata del linguaggio aiuterebbe nella diagnosi tra i giovani a rischio: https://www.quotidianosanita.it/scienza-e-farmaci/articolo.php?articolo_id=58494
(French)
Prédire la schizophrénie par ordinateur: https://www.lemonde.fr/sciences/article/2015/08/31/predire-la-schizophrenie-par-ordinateur_4741621_1650684.html
Videos:
Frontiers in Psychiatric Treatment: Psychosis Risk : https://www.youtube.com/watch?v=UALUynGdnFo
Cannabis and Psychosis: https://med.stanford.edu/peppnet/education/webinars.html
Language and Psychosis: https://www.youtube.com/watch?v=-lBKSiwZtzU
Speech and Language Analysis for COVID-19:
https://physicians.mountsinai.org/videos/speech-and-language-analysis-for-covid-19
https://health.mountsinai.org/blog/treating-young-people-at-risk-of-developing-psychosis/
Team
Shaynna Herrera, PhD
Project Director
Alessia Mcgowan, Clinical Research Coordinator
Sophia (Sophie) Shuster, Clinical Research Coordinator
Matthew Cotter, Clinical Research Coordinator
Riaz Shaik, PhD
Postdoctoral Fellow
Shreya Vaidya, Research Volunteer
