Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals with Spinal Cord Injury (SCI)

Researchers at the Bronx VA and Mount Sinai Hospital are investigating a drug for treating SCI-associated hypotension for optimal dose, effectiveness and safety. Hypotension, or abnormally low blood pressure, is common in people with SCI due to a compromised autonomic nervous system (ANS), the part responsible for controlling many bodily functions one does not think about (i.e. heart rate and blood pressure). We are currently seeking individuals fitting the following criteria:

  • Between the ages of 18-85 years old
  • SCI duration > 1 year
  • Wheelchair dependent
  • Low Blood Pressure:
    • For men: anything less than 110/70 mmHg
    • For women: anything less than 100/70 mmHg
  • Any level of injury
  • Any AIS grade of SCI
  • Non-ventilator dependent

Initial screening visits take approximately 1 hour and include a medical intake and history review, a symptoms survey related to low blood pressure, and 10-minute measurements of heart rate and blood pressure in a seated and lying down position. Participants will be compensated $25 for their time. Moreover, during this visit additional information regarding subsequent phases of the study will be provided. Jill M Wecht, EdD  and Miguel X Escalon, MD are principal investigators for this project.

For more information please contact: : Matthew Maher at Matthew.Maher@va.gov/718-584-9000 ext 1706.