Non-coding RNA in cancer


Vladimir’s studies are devoted to understanding the mechanisms of immune tolerance induced by different cancers. Recently, it was shown that many cancers induce abnormal transcription of pericentromeric repeat RNA such as HSATII. We have previously evaluated that these long non-coding RNAs might remodel the tumor microenvironment and induce immune tolerance. We now aim to investigate the mechanisms of aberrant long non-coding RNA transcription in cancers and assess their recognition by innate immune system. We hope to answer this question by a range of molecular and cellular techniques: high-throughput sequencing analysis, RNA biochemistry, ELISA  and flow cytometry. Theses studies will contribute to a better understanding of the pathology of cancers and development of novel vaccination approaches against them.