Publications

The Covers

largecover MCB-2015 CoverNRC copy largecover 2 MCB-2011 NatureRevCan Cancer Cell 2002


Research Articles

(see farther below for additional past REVIEWS, COMMENTARIES and BOOK CHAPTERS)

Complete list of publications: http://www.ncbi.nlm.nih.gov/pubmed/?term=aguirre-ghiso

>16,000 citations, Google Scholar. h-index 44, i10-index 71.

  • Zijlstra A, Von Lersner A, Yu D, Borrello L, Oudin M, Kang Y, Sahai E, Fingleton B, Stein U, Cox TR, Price JT, Kato Y, Welm AL, Aguirre-Ghiso JA; Board Members of the Metastasis Research Society. The importance of developing therapies targeting the biological spectrum of metastatic diseaseClin Exp Metastasis. 2019 May 17. doi: 10.1007/s10585-019-09972-3. [Epub ahead of print] PMID:31102066.
  • Liu PH, Shah RB, Li Y, Arora A, Ung PM, Raman R, Gorbatenko A, Kozono S, Zhou XZ, Brechin V, Barbaro JM, Thompson R, White RM, Aguirre-Ghiso JA, Heymach JV, Lu KP, Silva JM, Panageas KS, Schlessinger A, Maki RG, Skinner HD, de Stanchina E, Sidi S. An IRAK1-PIN1 signalling axis drives intrinsic tumor resistance to radiation therapyNat Cell Biol. 2019 Jan 21. doi: 10.1038/s41556-018-0260-7 https://www.ncbi.nlm.nih.gov/pubmed/30664786
  • Lapadula D, Farias E, Randolph CE, Purwin T, McGrath D, Charpentier T, Zhang L, Wu S, Terai M, Sato T, Tall GG, Zhou N, Wedegaertner P, Aplin AE, Aguirre-Ghiso J, Benovic JL. Effects of Oncogenic Gαq and Gα11 Inhibition by FR900359 in Uveal MelanomaMol Cancer Res. 2018 Dec 19. pii: molcanres.0574.2018. doi: 10.1158/1541-7786.MCR-18-0574.https://www.ncbi.nlm.nih.gov/pubmed/30567972
  • Borgen E, Rypdal MC, Sosa MS, Renolen A, Schlichting E, Lønning PE, Synnestvedt M, Aguirre-Ghiso JA, Naume B. NR2F1 stratifies dormant disseminated tumor cells in breast cancer patients. Breast Cancer Res. 2018 Oct 16;20(1):120. doi: 10.1186/s13058-018-1049-0 https://www.ncbi.nlm.nih.gov/pubmed/30322396
  • Aguirre-Ghiso JA.How dormant cancer persists and reawakens. Science. 2018 Sep 28;361(6409):1314-1315. doi: 10.1126/science.aav0191. No abstract available.https://www.ncbi.nlm.nih.gov/pubmed/30262486
  • Nobre AR, Entenberg D, Wang Y, Condeelis J, Aguirre-Ghiso JA. The Different Routes to Metastasis via Hypoxia-Regulated ProgramsTrends Cell Biol. 2018 Nov;28(11):941-956. doi: 10.1016/j.tcb.2018.06.008. Epub 2018 Jul 23. Review.https://www.ncbi.nlm.nih.gov/pubmed/30041830
  • Linde N, Casanova-Acebes M, Sosa MS, Mortha A, Rahman A, Farias EF, Harper K, Tardio E, Reyes Torres I, Jones J, Condeelis J, Merad M, and Aguirre-Ghiso JA.Macrophages orchestrate breast cancer early dissemination and metastasis. Nature Communications 9, 21(2018) doi:10.1038/s41467-017-02481-5. Highlighted in: https://f1000.com/prime/732394311. Editors choice, Science TM: http://stm.sciencemag.org/content/10/425/eaar7521
  • Entenberg D, Pastoriza JM, Oktay MH, Voiculescu S, Wang Y, Sosa MS, Aguirre-Ghiso JA,Condeelis J,Time-lapsed, large-volume, high-resolution intravital imaging for tissue-wide analysis of single cell dynamics, Methods, Volume 128, 1 September 2017, Pages 65-77, ISSN 1046-2023, https://doi.org/10.1016/j.ymeth.2017.07.019.
  • Fluegen G, Avivar-Valderas A, Wang Y, Padgen M, Williams JK, Nobre AR, Calvo V, Cheun JF, Bravo Cordero J, Entenberg D, Castracane J , Verkhusha V, Keely PJ, Condeelis J and Aguirre-Ghiso, JA. Phenotypic heterogeneity of disseminated tumor cells is preset by primary tumor hypoxic microenvironments. Nature Cell Biology (2017) doi:10.1038/ncb3465. Highlighted in Science Translational Medicine Editor’s Choice, Science Translational Medicine  15 Feb 2017: Vol. 9, Issue 377, eaam6063 DOI: 10.1126/scitranslmed.aam6063 https://f1000.com/prime/727233649
  • Harper KL, Sosa MS, Entenberg D, Hosseini H, Cheung JF, Nobre R, Avivar-Valderas A, Nagi C, Girnius N, Davis RJ, Farias EF, Condeelis J, Klein CA, Aguirre-Ghiso JA. Mechanism of early dissemination and metastasis in HER2+ mammary cancer. Nature. (2016) Dec 14. doi: 10.1038/nature20609. [Epub ahead of print] PMID:27974798. Paper highlighted in Nature News and Views. Nature. 2016 Dec 14. doi: 10.1038/nature21104. Highlighted by Faculty of 1000. https://f1000.com/prime/727099751; Highlighted in Nature Reviews  Cancer http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.html
  • Hosseini, H,  Obradovic M, Harper K,  Sosa MS, Nanduri LK, Werno C, Hoffman, M, Ehrl C, Maneck M, Patwary N, Haunschild G, Reimelt C, Weeber F, Hartkopf A, Taran FA, Brucker SY, Fehm T, Meister G, Aguirre-Ghiso JA, Klein CA. Early dissemination seeds metastasis in breast cancer. Nature. (2016) Dec 14. doi: 10.1038/nature20785. [Epub ahead of print] PMID:27974799. Paper highlighted in Nature News and Views. Nature. 2016 Dec 14. doi: 10.1038/nature21104. Highlighted in Nature Reviews  Cancer http://www.nature.com/nrc/journal/v17/n2/full/nrc.2017.4.html.                     https://f1000.com/prime/727099750
  • Kenji Yumoto, Matthew R. Eber, Jingcheng Wang, Frank C. Cackowski, Ann M. Decker, Eunsohl Lee, Ana Rita Nobre, Julio A. Aguirre-Ghiso, Younghun Jung and Russell S. Taichman. Axl is required for TGF-β2-induced dormancy of prostate cancer cells in the bone marrow. Scientific Reports (2016) Nov 7;6:36520. doi: 10.1038/srep36520.
  • Cackowski F, Eber MR, Rhee J, Decker A, Yumoto K, Berry JE, Lee E, Shiozawa Y, Jung Y, Aguirre-Ghiso JA, Taichman RS. Mer Tyrosine Kinase Regulates Disseminated Prostate Cancer Cellular Dormancy. J Cell Biochem. (2016) Oct 18. doi: 10.1002/jcb.25768. [Epub ahead of print] PMID: 27753136
  • Chung CY, Sun Z, Mullokandov G, Bosch A,Qadeer ZA, Cihan E, Rapp Z, Parsons R, Aguirre-Ghiso JA, Farias EF, Brown BD, Gaspar-Maia A,Bernstein E. Cbx8 acts non-canonically in breast cancer to promote Notch signaling. Cell Reports (2016). Jul 12;16(2):472-86. doi: 10.1016/j.celrep.2016.06.002. Epub 2016 Jun 23. PMID:27346354.
  • James K. Williams, David Entenberg, Yarong Wang, Alvaro Avivar-Valderas, Michael Padgena, Ashley Clark, Julio A. Aguirre-Ghiso, James Castracane, John S. Condeelis.Validation of a device for the active manipulation of the tumor microenvironment during intravital imaging. Intravital (2016);5(2). pii: e1182271. PMID: 27790386
    http://dx.doi.org/10.1080/21659087.2016.1182271
  • Joseph M. Szulczewski, David R. Inman, David Entenberg, Julio A. Aguirre-Ghiso, James Castracane, John Condeelis, Kevin W. Eliceiri, Patricia J. Keely. In Vivo Visualization of Stromal Macrophages via label-free FLIM-based metabolite imaging. Scientific Reports. (2016) May 25;6:25086. doi: 10.1038/srep25086.PMID: 27220760
  • Li M, Pathak RR, Lopez-Rivera E, Friedman SL, Aguirre-Ghiso JA, Sikora AG. The In Ovo Chick Chorioallantoic Membrane (CAM) Assay as an Efficient Xenograft Model of Hepatocellular Carcinoma. J Vis Exp. (2015) Oct 9;(104). doi: 10.3791/52411.
  • Alsadeq A, Strube S, Krause S, Carlet M, Jeremias I, Vokuhl C, Loges S, Aguirre-Ghiso JA, Trauzold A, Cario G, Stanulla M, Schrappe M, Schewe DM. Effects of p38α/β inhibition on acute lymphoblastic leukemia proliferation and survival in vivo. Leukemia. (2015) Jun 24. doi: 10.1038/leu.2015.153. [Epub ahead of print] PMID: 26104660
  • Adomako A, Calvo V, Biran N, Osman K, Chari A, Paton JC, Paton AW, Moore K, Schewe DM, Aguirre-Ghiso JA. Identification of markers that functionally define a quiescent multiple myeloma cell sub-population surviving bortezomib treatment. BMC Cancer. (2015) May 30;15:444. doi: 10.1186/s12885-015-1460-1. PMCID: PMC4448210# Highlighted by BMC Cancer in the “Highly Accessed” category.
  • Hasegawa D, Calvo V, Avivar-Valderas A, Lade A, Chou HI, Lee YA, Farias EF, Aguirre-Ghiso JA, Friedman SL. Epithelial Xbp1 is Required for Cellular Proliferation and Differentiation During Mammary Gland Development. Mol Cell Biol. 2015 Feb 23. pii: MCB.00136-15. PMID: 25713103 -Cover article for the Feb 23 issue of Mol Cell Biol.
  • Sosa MS, Parikh F, Maia AG, Estrada Y, Bosch A, Bragado P, Ekpin E, George A, Zheng Y, Lam HM, Morrissey C, Chung CY, Farias EF, Bernstein E, Aguirre-Ghiso JA. NR2F1 controls tumour cell dormancy via SOX9- and RARβ-driven quiescence programmes. Nat Commun. 2015 Jan 30;6:6170. doi: 10.1038/ncomms7170. PubMed PMID:25636082; PubMed Central PMCID: PMC4313575. # – In the top 10% of all articles ever tracked by Altmetric. https://f1000.com/prime/725332493
  • Chéry L, Lam HM, Coleman I, Lakely B, Coleman R, Larson S, Aguirre-Ghiso JA, Xia J, Gulati R, Nelson PS, Montgomery B, Lange P, Snyder LA, Vessella RL, Morrissey C. Characterization of single disseminated prostate cancer cells Reveals tumor cell heterogeneity and identifies dormancy associated pathways. Oncotarget. 2014 Oct 30;5(20):9939-51. PubMed PMID: 25301725; PubMed Central PMCID: PMC4259449.
  • Lopez-Rivera E, Jayaraman P, Parikh F, Davies MA, Ekmekcioglu S, Izadmehr S, Milton DR, Chipuk JE, Grimm EA, Estrada Y, Aguirre-Ghiso J, Sikora AG. Inducible nitric oxide synthase drives mTOR pathway activation and proliferation of human melanoma by reversible nitrosylation of TSC2.Cancer Res. 2014 Feb 15;74(4):1067-78. doi: 10.1158/0008-5472.CAN-13-0588. Epub 2014 Jan 7. PMID: 24398473 [PubMed – indexed for MEDLINE]
  • Bragado P., Estrada Y., Parikh F., Krause S., Capobianco C., Farina H.G., Schewe D.M., and Julio A. Aguirre-Ghiso JA. TGFβ2 dictates disseminated tumour cell fate in target organs through TGFβ-RIII and p38α/β signalling. Nat. Cell. Bio. (2013). Nov;15(11):1351-61. doi: 10.1038/ncb2861. Epub 2013 Oct 27. PMID: 24161934; PMCID: not available. Highlighted in Science Signaling Editor’s Choice, Cancer Research Breaking Advances section and several public news outlets.# – Featured in the Cover of the November 15th issue of Nat Cell Bio. Ranks #6 for articles of similar age in Nat Rev Cancer and is in the top 5% of all articles ever tracked by Altmetric. https://f1000.com/prime/718155734
  • Ulrike Begley, Maria Soledad Sosa, Alvaro Avivar-Valderas, Ashish Patil, Lauren Endres, Yeriel Estrada, Clement T.Y. Chan, Dan Su, Peter C. Dedon, Julio A. Aguirre-Ghiso and Thomas. A human tRNA methyltransferase 9-like protein prevents tumor growth by regulating LIN9 and the hypoxic response. EMBO Mol Med (2013) Feb 4. doi: 10.1002/emmm.201201161.#
  • A Avivar-Valderas, E Bobrovnikova-Marjon, J Alan Diehl, N Bardeesy, J Debnath and Julio A. Aguirre-Ghiso. Regulation of autophagy during ECM detachment is linked to a selective inhibition of mTORC1 by PERK.  Oncogene (2012), Nov 19. doi: 10.1038/onc.2012.512..#
  • Ryung S. Kim, Alvaro Avivar Valderas, Yeriel Estrada, Paloma Bragado, Maria Soledad Sosa, Julio A. Aguirre-Ghiso, and Jeffrey E. Segall. Dormancy signatures and metastasis in estrogen receptor positive breast cancer. PLoS One (2012) ;7(4):e35569. Epub 2012 Apr 18.#
  • Paloma Bragado, Yeriel Estrada, Maria Soledad Sosa, Alvaro Avivar-Valderas, David Cannan, Eric Genden, Marita Teng, Aparna C. Ranganathan, Huei-Chi Wen, Avnish Kapoor, Emily Bernstein and Julio A. Aguirre-Ghiso. Analysis of marker-defined HNSCC subpopulations reveals a dynamic regulation of tumor initiating properties. PLoS One. (2012) ;7(1):e29974. PMCID: PMC3262798. # 
  • Tong CC, Lau KH, Rivera M, Cannan D, Julio A. Aguirre-Ghiso, Sikora AG, Gupta V, Forsythe K, Ko EC, Misiukiewicz K, Gurudutt V, Teng MS, Packer SH, Genden EM, Kao J. Prognostic significance of p16 in locoregionally advanced head and neck cancer treated with concurrent 5-fluorouracil, hydroxyurea, cetuximab and intensity-modulated radiation therapy. Oncol Rep. (2012) May;27(5):1580-6. doi: 10.3892/or.2012.1679.
  • Álvaro Gutiérrez-Uzquiza, María Arechederra, Paloma Bragado, Julio A. Aguirre-Ghiso, Almudena Porras. p38a mediates cell survival in response to oxidative stress via induction of antioxidant genes. Effect on p70S6K pathway. J Biol Chem. (2012) Jan 20;287(4):2632-42. Epub 2011 Dec 2.
  • Shibo Fu, Michael Rivera, Eric C Ko, Andrew G. Sikora, Chien-Ting Chen, Ha Linh Vu, David Cannan, Samuel Eisenstein, Barry S. Rosenstein, Julio Aguirre-Ghiso, Shu-Hsia Chen and Johnny Kao. Combined Inhibition of Epidermal Growth Factor Receptor and Cyclooxygenase-2 as a Novel Approach to Enhance Radiotherapy. J Cell Sci Ther (2011) S1:002. doi:10.4172/2157-7013.S1-002.
  • Alvaro Avivar-Valderas, Eduardo Salas, Ekaterina Bobrovnikova-Marjon, J. Alan Diehl, Chandandeep Nagi, Jayanta Debnath, and Julio A. Aguirre-Ghiso. PERK integrates autophagy and oxidative stress responses to promote survival during ECM detachment. Mol Cell Biol. (2011) Sep;31(17):3616-29. PMC3165554 (Cover article)# 
  • Huei-Chi Wen, Alvaro Avivar-Valderas, M. Soledad Sosa, Nomeda Girinius, Eduardo F. Farias, Roger Davis and Julio A. Aguirre-Ghiso. p38a signaling regulates ATF2/c-Jun and BimEL to induce anoikis and lumen formation during mammary morphogenesis. Science Signaling (2011) 4 (174), ra34. [DOI: 10.1126/scisignal.2001684].
  • Yuki Ishii, Luena Papa, Urvashi Bahadur, Zhenyu Yue, Julio Aguirre-Ghiso, Toshi Shioda, Samuel Waxman, and Doris Germain. Bortezomib enhances the efficacy of fulvestrant by amplifying the aggregation of theestrogen receptor, which leads to a pro-apoptotic unfolded protein response. Cancer Res. (2011) Feb 3. [Epub ahead of print]
  • Sharon J. Sequeira, Huei-Chi Wen, Alvaro Avivar Valderas and Julio A. Aguirre-Ghiso. Inhibition of eIF2a dephosphorylation inhibits ErbB2-induced deregulation of mammary acinar morphogenesis. BMC Cell Biology. (2009) Sep 15;10:64.#
  • Denis M Schewe and Julio A Aguirre-Ghiso. Inhibition of eIF2a dephosphorylation eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy. Cancer Res. (2009) Feb 15;69(4):1545-52. #
  • Alejandro P. Adam, Ajish George, Paloma Bragado, Bibiana V. Iglesias, Denis Schewe, Aparna Ranganathan, Antonis Kourtidis, Douglas S. Conklin and Julio A. Aguirre-Ghiso. Computational identification of a p38SAPK regulated transcription factor network required for tumor cell quiescence. Cancer Res. (2009) Jul 15;69(14):5664-72. Epub 2009 Jul 7. #
  • Denis M. Schewe and Julio A. Aguirre-Ghiso. ATF6α-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo. Proc Natl Acad Sci U S A. (2008) Jul 29;105(30):10519-24. Highlighted in “This week in PNAS” section of the journal.Faculty of 1000 evaluation:www.f1000biology.com/article/id/1119501/evaluation #
  • Aparna C. Ranganathan, Shishir Ohja, Antonis Kourtidis, Douglas Conklin and Julio A. Aguirre-Ghiso. Dual function of PERK in tumor cell growth arrest and survival. Cancer Res (2008); 68(9): 1–9. #
  • Sharon J. Sequeira, Aparna C. Ranganathan, Alejandro P. Adam, Bibiana V. Iglesias, Eduardo F. Farias and Julio A. Aguirre-Ghiso. Inhibition of Proliferation by PERK Regulates Mammary Acinar Morphogenesis and Tumor Formation. PLoS ONE. (2007) Jul 18; 2:e615. #
  • Timothy E. Baron, Michele T. Lastro, Aparna C. Ranganathan, Scott A. Tenenbaum, Douglas S. Conklin, and Julio A. Aguirre-Ghiso. Ribonomic and Short Hairpin RNA Gene Silencing Methods to Explore Functional Gene Programs Associated with Tumor Growth Arrest. Methods Mol Biol. (2007); 383:227-44.#
  • Mio Shinohara, Alexei V. Mikhailov, Julio A. Aguirre-Ghiso and Conly L. Rieder. ERK1/2 activation is required for timely progress through early G2 but it is not directly involved in the G2/M or M/A transitions in mammalian cells. Molecular Biology of the Cell. (2006) Dec 1st. 17: 5227-5240.
  • Chaurasia, P., Julio A. Aguirre-Ghiso, Liang O.D., Gardsvoll, H., Ploug, M., and Ossowski, L. A region in uPAR domain III controlling a functional association with a5b1 integrin and tumor growth. J. Biol. Chem. (2006) May 26; 281(21): 14852-63.
  • Ranganathan AC, Zhang L, Adam AP, and Julio A. Aguirre Ghiso. Functional coupling of p38-induced upregulation of BiP and activation of RNA-dependent protein kinase–like ER kinase (PERK) to drug resistance of dormant carcinoma cells. Cancer Research (2006); 66: (3) 1702-11. #
  • Kip M. Connor, Sita Subbaram, Kevin J. Regan, Kristin K. Nelson, Joseph E. Mazurkiewicz, Peter J. Bartholomew, Andrew E. Aplin, Yu-Tzu Tai, Julio Aguirre-Ghiso, Sonia C. Flores and J. Andres Melendez. Mitochondrial H2O2 Regulates the Angiogenic Phenotype Via PTEN Oxidation. J. Biol. Chem. (2005) 29; 280(17): 16916-24.
  • Julio A. Aguirre-Ghiso, Liliana Ossowski and Sarah K. Rosenbaum. GFP tagging of ERK and p38 pathways reveals novel dynamics of pathway activation during primary and metastatic growth. Cancer Res (2004); 64(20): 7336-45. Faculty of 1000 evaluation at: www.f1000biology.com/article/15492254/evaluation. #
  • Esteban Mazzoni, Alejandro Adam, Elisa Bal de Kier Joffe and Julio A. Aguirre-Ghiso. Immortalized mammary epithelial cells overexpressing PKCg acquire a malignant phenotype and become tumorigenic in vivo. Molecular Cancer Res. (2003) 1:776-787#
  • Julio A. Aguirre-Ghiso, Yeriel Estrada, David Liu and Liliana Ossowski. ERK (MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38 (SAPK). Cancer Res. (2003); 63(7): 1684-95.
  • Puricelli L, Proiettii CJ, Labriola L, Salatino M, Balana ME, Julio A. Aguirre Ghiso, Lupu R, Pignataro OP, Charreau EH, Bal de Kier Joffe E, Elizalde PV. Heregulin inhibits proliferation via ERKs and phosphatidyl-inositol 3-kinase activation but regulates urokinase plasminogen activator independently of these pathways in metastatic mammary tumor cells. Int. J. Cancer. (2002) 100(6): 642-53.
  • David Liu, Julio A. Aguirre-Ghiso, Yeriel Estrada and Liliana Ossowski. EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma. Cancer Cell (2002); 1: 445-457 (Cover). http://www.cell.com/cancer-cell/abstract/S1535-6108(02)00076-4. Faculty of 1000 Evaluation at:www.f1000biology.com/article/12124174/evaluation.
  • Julio Aguirre-Ghiso. Inhibition of FAK signaling activated by urokinase receptor induces human carcinoma dormancy in vivo. Oncogene (2002) 21(16): 2513-24. #
  • Virginia Ladeda, Paul Frankel, Larry A. Feig, David A. Foster, Elisa Bal de Kier Joffe, Julio A. Aguirre-Ghiso. RalA mediates v-Src, v-Ras, and v-Raf regulation of CD44 and fibronectin expression in NIH3T3 fibroblasts. Biochem Biophys Res Commun. (2001) 283(4): 854-61. #
  • Julio A. Aguirre Ghiso, David Liu, Andrea Mignatti, Katherine Kovalski and Liliana Ossowski. Urokinase receptor and fibronectin regulate the ERKMAPK to p38MAPK activity ratios that determine carcinoma cell proliferation or dormancy in vivo. MolBiol. Cell (2001). 12, 4, 863-879.
  • Julio A. Aguirre Ghiso, Katherine Kovalski and Liliana Ossowski. Tumor dormancy due to urokinase receptor down-regulation in human carcinoma involves integrin and MAPK signaling. J. Cell Biol. (1999) 147, 89-103.      Highlighted in the In Brief section of JCB.
  • Julio A. Aguirre Ghiso, Paul Frankel, Eduardo Farías, Zhimin Lu, Hong Jiang, Amanda Olsen, Larry Feig, Elisa Bal de Kier Joffé and David Foster. Ral-A requirement for v-Src- and v-Ras-induced tumorigenicity and overproduction of urokinase-type plasminogen activator. Involvement of metalloproteinases. Oncogene (1999), 18, 4718-4725. #
  • Alejandro J. Urtreger, Julio A. Aguirre Ghiso, Santiago Werbahj, Lydia Puricelli, Andrés Muro, Elisa Bal de Kier Joffé. Involvement of fibronectin in the regulation of urokinase production and binding in murine mammary tumor cells. Int. J. Cancer, (1999), vol. 82, 748-753.
  • Virginia Ladeda, Julio A. Aguirre Ghiso, Elisa Bal de Kier Joffé. Function and Expression of CD44 During Spreading and Migration of Murine Carcinoma cells. Exp. Cell Res. (1998); 242:515-527.
  • Julio A. Aguirre Ghiso, Eduardo F. Farías, Daniel F. Alonso, and Elisa Bal de Kier Joffé. Secretion of urokinase and metalloproteinase-9 induced by staurosporine is dependent on a tyrosine-kinase pathway in mammary tumor cells. Int. J. Cancer (1998) 76: 362-367. #
  • Eduardo F. Farías, Julio A. Aguirre Ghiso, Virginia Ladeda and Elisa Bal de Kier Joffé. Verapamil Inhibits Proteases Production, Local Invasion and Metastasis Development of Murine Carcinoma Cells. Int. J. Cancer. (1998) 78 (6): 727-734.
  • Julio A. Aguirre Ghiso, Eduardo F. Farías, Daniel F. Alonso, Carlos Arregui and Elisa Bal de Kier Joffé. A Phospholipase D and Protein Kinase C Inhibitor Blocks the Spreading of Murine Mammary Adenocarcinoma Cells Altering F-Actin and bIntegrin Point Contact Distribution. Int. J. Cancer. (1997) 71: 881-890. #
  • Julio A. Aguirre Ghiso, Daniel F. Alonso, Eduardo Farías and Elisa Bal de Kier Joffé. Overproduction of urokinase-type plasminogen activator is regulated by phospholipase D and protein kinase C pathways in murine mammary adenocarcinoma cells. Biochim. Biophys. Acta (1997) 1356: 171-184. #
  • A. Aguirre Ghiso, Miriam Diament, Isabel D’elia, Elisa Bal de Kier Joffé and Slobodanka Klein. Effect of in vivo culture of murine mammary adenocarcinoma cells on tumor and metastatic growth. Tumor Biol. (1997); 18: 41-52.
  • Julio A. Aguirre Ghiso, Eduardo Farías, Diego M. Fernandez, Daniel F. Alonso and Elisa Bal de Kier Joffé. Down modulation of tumor cells-associated proteolytic activity by n-butanol treatment in cultured murine mammary adenocarcinoma cells. Int. J Oncol. (1996); 8: 35-39.
  • Klein, María Adela Jasnis, Miriam Diament, Lilia Davel, Julio A. Aguirre Ghiso, Yolanda P. de Bonaparte. Immunomodulation by soluble factors from tumor cells cultured in vivo in diffusion chambers. Tumor Biol. (1994); 15: 160-165.

Reviews, Commentaries, Perspectives and other Peer Reviewed Publications

  • Aguirre-Ghiso JA and Sosa MS. Emerging topics on disseminated cancer cell dormancy and the paradigm of metastasis. Annual Reviews of Cancer Biology. In Press
  • Sosa, M.S., Bernstein, E. & Aguirre-Ghiso, J.A. Epigenetic Regulation of Cancer Dormancy as a Plasticity Mechanism for Metastasis Initiation. in Tumor Dormancy and Recurrence (eds. Wang, Y. & Crea, F.) 1-16 (Springer International Publishing, Cham, 2017).
  • Linde N, Fluegen G, Aguirre-Ghiso JA. The Relationship Between Dormant Cancer Cells and Their Microenvironment. Adv Cancer Res. 2016 ;132:45-71. doi: 10.1016/bs.acr.2016.07.002. Epub 2016 Aug 25. PMID:27613129. https://f1000.com/prime/726728085
  • Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso, et al., Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2016 Jan 2;12(1):1-222. No abstract available. PMID: 26799652
  • Goossens N, Hoshida Y, Aguirre-Ghiso Origin and interpretation of cancer transcriptome profiling: the essential role of the stroma in determining prognosis and drug resistance. EMBO Mol Med. 2015 Aug 3. pii: e201505284. doi: 10.15252/emmm.201505284. [Epub ahead of print]
  • Sosa MS, Bragado P, Aguirre-Ghiso JA. Mechanisms of disseminated cancer cell dormancy: an awakening field. Nat Rev Cancer. 2014 Sep;14(9):611-22. doi:10.1038/nrc3793. Epub 2014 Aug 14. Review. PubMed PMID: 25118602; PubMed Central. PMCID: PMC4230700.-Cover article for the September 14th issue of Nat Rev Cancer-Ranks #6 for articles of similar age in Nat Rev Cancer and is in the top 5% of all articles ever tracked by Altmetric.
  • Linde N, Sosa MS, Aguirre-Ghiso JA. Integration of microenvironmental and stress signaling antagonizes colorectal cancer progression. EMBO J. 2014 Aug 18;33(16):1737-9. doi: 10.15252/embj.201489364. Epub 2014 Jul 14. PubMed PMID: 25024435; PubMed Central PMCID: PMC4195757
  • Avivar-Valderas A, Wen HC, Aguirre-Ghiso JA. Stress signaling and the shaping of the mammary tissue in development and cancer. Oncogene. 2014 Nov 27;33(48):5483-90. doi: 10.1038/onc.2013.554. Epub 2014 Jan 13. Review. PubMed PMID: 24413078; PubMed Central PMCID: PMC4096615.
  • Aguirre-Ghiso, JA, Bragado P, Sosa MS. Metastasis awakening: targeting dormant cancer. Nat Med. 2013 Mar;19(3):276-7. doi: 10.1038/nm.3120. PMID: 23467238 [PubMed – indexed for MEDLINE] PMCID: PMC3651698
  • Sosa MS, Bragado P, Debnath J, Aguirre-Ghiso Regulation of tumor cell dormancy by tissue microenvironments and autophagy. Adv Exp Med Biol. (2013);734:73-89. doi: 10.1007/978-1-4614-1445-2_5.
  • Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, et al., Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. (2012) Apr;8(4):445-544.
  • Bragado P, Sosa MS, Keely P, Condeelis J, Aguirre-Ghiso JA. Microenvironments dictating tumor cell dormancy. Recent Results Cancer Res. (2012);195:25-39.
  • Cagan RL, Aguirre-Ghiso JA. A local view of cancer. Dev Cell. (2012) Mar 13;22(3):472-4.
  • Genden EM, Aguirre-Ghiso JA. Oropharyngeal cancer biology and treatment: insights from messenger RNA sequence analysis and transoral robotic surgery. Mayo Clin Proc. (2012) Mar;87(3):211-2.
  • Maria Soledad Sosa, Alvaro-Avivar Valderas, Paloma Bragado, Huei Chi Wen, Aguirre-Ghiso JA. Molecular Pathways: ERK1/2 and p38α/β signaling in tumor cell quiescence: opportunities to control dormant residual disease. Invited Article.Clin. Cancer Res. (2011) Sep 15;17(18):5850-7. https://f1000.com/prime/725506458#recommendations-content
  • Prince A., Aguirre-Ghiso, JA, Genden E., Posner M., Sikora A. Head and neck squamous cell carcinoma: new translational therapies. Mt. Sinai J. Med., (2010). 77 (6): 684-99.
  • Aguirre-Ghiso JA. On the theory of tumor self-seeding: implications for metastasis progression in humans. Breast Cancer Res. (2010) Apr 28;12(2):304.Viewpoint
  • Ossowski L, Aguirre-Ghiso JA. Dormancy of metastatic melanoma. Pigment Cell Melanoma Res. (2010) Feb;23(1):41-56. Epub 2009 Oct 19.
  • Allgayer H and Aguirre-Ghiso JA The urokinase receptor (u-PAR) – a link between tumor cell dormancy and minimal residual disease in bone marrow? APMIS (2008); 116 (7-8) 602-614
  • Aguirre-Ghiso JA. Models, mechanisms and clinical evidence for cancer dormancy. Nature Reviews Cancer. (2007). Nov; 7(11): 834-46. (Cover and featured article). https://f1000.com/prime/721869692#recommendations-content
  • Aguirre-Ghiso JA. The problem of cancer dormancy: understanding the basic mechanisms and identifying therapeutic opportunities. Cell Cycle. (2006) Aug; 5(16): 1740-3. (Guest Editor). Introductory Review. Invited peer reviewed article. Cover.  (Issue Guest Editor)
  • Ranganathan AC, Adam AP and Aguirre-Ghiso JA. Opposing roles of mitogenic and stress signaling pathways in the induction of cancer dormancy. Cell Cycle. (2006) Aug; 5(16): 1799-807. Invited Review. Cover.
  • Ranganathan AC, Adam AP, Zhang L, and Aguirre-Ghiso JA. Tumor cell dormancy induced by p38SAPK and ER-stress signaling; an adaptive advantage for metastatic cells? Cancer Biology & Therapy (2006) Jul; 5(7): 729-35.
  • Tenenbaum SA and Aguirre-Ghiso JA. Dephosphorylation Shows SR Proteins the Way Out. Molecular Cell (2005); 20 (4); 499-501.
  • Ossowski L and Aguirre-Ghiso JA. Urokinase receptor and integrin partnership: coordination of signaling for cell adhesion, migration and growth. Current Opinion in Cell Biology (2000) 12(5): 613-20. #
  • Bal de Kier Joffe, E., Mazzoni, EO, Aguirre-Ghiso JA. Signaling pathways regulating the expression of proteases during tumor progression. (In Spanish) Medicina (B Aires) (2000); 60:34-40.
  • Ossowski, Aguirre-Ghiso JA., Liu D, Yu W and Kovalski K. The role of plasminogen activator receptor in cancer invasion and dormancy. Medicina (Buenos Aires) (1999) 59, 547-552
  • Aguirre-Ghiso JA, Alonso DF, Farías EF, Gomez D and Bal de Kier Joffé, E. Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype. European, J. Biochem. (1999) 263, 2, 295-304 (Cover).

Book Chapters

  • Maria Soledad Sosa, Paloma Bragado, Jayanta Debnath and Julio A. Aguirre-Ghiso. Regulation of Tumor Cell Dormancy by Tissue Microenvironments and Autophagy. Systems Biology of Tumor Dormancy. Editors, Enderling H, Almog N and Hlatky L. (2012) Springer Science + Business Media, INC.
  • Paloma Bragado, Maria Soledad Sosa, Patricia Keely, John Condeelis and Julio A. Aguirre-Ghiso. Microenvironments dictating tumor cell dormancy. Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer (Eds: K. Pantel, C. Sotiriou, M. Ignatiadis). Recent Results Cancer Res. (2012);195:25-39. doi: 10.1007/978-3-642-28160-0_3
  • Julio A. Aguirre-Ghiso, Daniel F. Alonso and Eduardo F. Farias. Function and expression of the uPA/uPAR system in cancer metastasis. Cancer Metastasis: Biologic Basis and Therapeutics Cambridge University Press, Editors: Danny Welch, Danny R. Welch, Ph.D., David C. Lyden, MD, PhD, and Beth Psaila, MD. 2009. (invited)
  • Paloma Bragado, Aparna C. Ranganathan and Julio A. Aguirre-Ghiso*. Dormancy of Disseminated Tumor Cells: Reciprocal crosstalk with the microenvironment. The Tumor Microenvironment-Cancer Drug Discovery and Development. Springer Science + Business Media LLC, Humana Press. Dr. Rebecca Bagley, Editor. 2010, Part 2, pp229-254. (invited)

Non-Peer Reviewed Publications 

Julio A. Aguirre-Ghiso, Denis M Schewe, Aparna Ranganathan. Mechanisms of cancer cell dormancy. Translational Oncology Reviews (Spain). Numero 5 Noviembre 2009.